Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vagCD/VapC-VagC
Location 27375..28018 Replicon plasmid unnamed1
Accession NZ_CP016160
Organism Klebsiella pneumoniae strain TH1 isolate TH1

Toxin (Protein)


Gene name vagD Uniprot ID -
Locus tag BAU11_RS25870 Protein ID WP_023345587.1
Coordinates 27602..28018 (+) Length 139 a.a.

Antitoxin (Protein)


Gene name vagC Uniprot ID -
Locus tag BAU11_RS25865 Protein ID WP_023345588.1
Coordinates 27375..27605 (+) Length 77 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
BAU11_RS25840 23467..23895 - 429 WP_023345594.1 nuclear transport factor 2 family protein -
BAU11_RS25845 24008..24853 - 846 WP_023345593.1 SDR family oxidoreductase -
BAU11_RS25850 24956..25351 + 396 WP_023345592.1 helix-turn-helix transcriptional regulator -
BAU11_RS25855 25463..26047 + 585 WP_023345591.1 TetR/AcrR family transcriptional regulator -
BAU11_RS25860 26115..26957 + 843 WP_064081525.1 nitroreductase family protein -
BAU11_RS25865 27375..27605 + 231 WP_023345588.1 AbrB/MazE/SpoVT family DNA-binding domain-containing protein Antitoxin
BAU11_RS25870 27602..28018 + 417 WP_023345587.1 type II toxin-antitoxin system VapC family toxin Toxin
BAU11_RS25875 28110..29514 - 1405 Protein_33 glycoside hydrolase family 1 protein -
BAU11_RS25880 29524..31398 - 1875 WP_064081469.1 beta-glucoside-specific PTS transporter subunit IIABC -
BAU11_RS25885 31788..32423 - 636 WP_064081470.1 DUF1349 domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Conjugative plasmid - ybtS / ybtX / ybtQ / ybtP / ybtA / irp2 / irp1 / ybtU / ybtT / ybtE / fyuA 1..165276 165276


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(6-129)

Antitoxin

SpoVT-AbrB domain

(7-48)


Sequences

Toxin        


Download         Length: 139 a.a.        Molecular weight: 15082.55 Da        Isoelectric Point: 7.8644

>T64262 WP_023345587.1 NZ_CP016160:27602-28018 [Klebsiella pneumoniae]
MKKTWMLDTNICSFIMREQPAAVLKRLEQAVLRGDRIVVSAVTYAEMRFGATGPKASPRHIQLVDAFCARLDAILPWDRA
AVDATTDIRVALRLAGTPIGPNDTAIAGHAIAAGAVLVTNNVREFERVPGLMLEDWVN

Download         Length: 417 bp

>T64262 NZ_CP016160:27602-28018 [Klebsiella pneumoniae]
ATGAAGAAAACCTGGATGCTCGACACGAACATCTGCTCGTTCATCATGCGCGAGCAGCCGGCAGCGGTGCTGAAGCGCCT
GGAGCAGGCGGTGCTGCGCGGTGATCGCATCGTGGTCTCGGCCGTGACGTACGCCGAGATGCGCTTCGGCGCCACCGGCC
CGAAGGCCTCGCCGCGCCATATTCAGCTGGTCGATGCGTTCTGCGCGCGCCTCGATGCCATCCTGCCCTGGGACCGCGCC
GCGGTGGACGCCACGACGGACATCCGGGTGGCGCTGCGCCTCGCCGGGACGCCGATCGGCCCGAACGACACGGCCATTGC
CGGGCACGCCATCGCGGCCGGCGCCGTCCTGGTGACGAACAATGTGCGGGAGTTTGAGCGGGTGCCGGGCCTGATGCTGG
AAGACTGGGTGAATTAA

Antitoxin


Download         Length: 77 a.a.        Molecular weight: 8677.73 Da        Isoelectric Point: 4.4563

>AT64262 WP_023345588.1 NZ_CP016160:27375-27605 [Klebsiella pneumoniae]
MRTVSIFKNGNNRAIRLPRDLDFEGVSELEIVREGDSIILRPVRPTWGSFAQLDRADPDFMAEREDVVSDEGRFAP

Download         Length: 231 bp

>AT64262 NZ_CP016160:27375-27605 [Klebsiella pneumoniae]
ATGAGAACCGTATCTATTTTTAAAAACGGCAACAACCGCGCCATCCGCCTGCCCCGCGATCTGGATTTTGAGGGGGTGAG
CGAGCTCGAGATCGTCCGGGAAGGGGATAGCATCATCCTGCGTCCCGTCCGGCCGACATGGGGCTCGTTCGCGCAACTGG
ACAGGGCCGATCCGGACTTTATGGCGGAGCGTGAGGATGTGGTCAGCGATGAAGGACGCTTTGCGCCATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References