Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) Hha-TomB/-
Location 1230349..1230968 Replicon chromosome
Accession NZ_CP016159
Organism Klebsiella pneumoniae strain TH1

Toxin (Protein)


Gene name Hha Uniprot ID R8WYV2
Locus tag BAU11_RS05995 Protein ID WP_002892050.1
Coordinates 1230750..1230968 (+) Length 73 a.a.

Antitoxin (Protein)


Gene name TomB Uniprot ID J2DPF6
Locus tag BAU11_RS05990 Protein ID WP_002892066.1
Coordinates 1230349..1230723 (+) Length 125 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
BAU11_RS05980 1225501..1226694 + 1194 WP_004177236.1 multidrug efflux RND transporter periplasmic adaptor subunit AcrA -
BAU11_RS05985 1226717..1229863 + 3147 WP_002892069.1 multidrug efflux RND transporter permease subunit AcrB -
BAU11_RS05990 1230349..1230723 + 375 WP_002892066.1 Hha toxicity modulator TomB Antitoxin
BAU11_RS05995 1230750..1230968 + 219 WP_002892050.1 hemolysin expression modulator Hha Toxin
BAU11_RS06000 1231127..1231693 + 567 WP_002892030.1 maltose O-acetyltransferase -
BAU11_RS29465 1231665..1231805 - 141 WP_004147370.1 hypothetical protein -
BAU11_RS06010 1231826..1232296 + 471 WP_002892026.1 YlaC family protein -
BAU11_RS06015 1232271..1233722 - 1452 WP_002892023.1 PLP-dependent aminotransferase family protein -
BAU11_RS06020 1233823..1234521 + 699 WP_002892021.1 GNAT family N-acetyltransferase -
BAU11_RS06025 1234518..1234658 - 141 WP_002892018.1 type B 50S ribosomal protein L36 -
BAU11_RS06030 1234658..1234921 - 264 WP_023283304.1 type B 50S ribosomal protein L31 -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Haemolysin expression modulating, HHA

(13-69)

Antitoxin

Biofilm formation regulator YbaJ

(1-116)


Sequences

Toxin        


Download         Length: 73 a.a.        Molecular weight: 8628.00 Da        Isoelectric Point: 8.9008

>T64246 WP_002892050.1 NZ_CP016159:1230750-1230968 [Klebsiella pneumoniae]
MSDKPLTKTDYLMRLRRCQTIDTLERVIEKNKYELSDNELAVFYSAADHRLAELTMNKLYDKIPTSVWKFIR

Download         Length: 219 bp

>T64246 NZ_CP016159:1230750-1230968 [Klebsiella pneumoniae]
ATGTCTGATAAGCCATTAACTAAAACAGACTATTTGATGCGCTTACGTCGTTGCCAGACAATTGACACGCTGGAGCGCGT
CATTGAAAAAAATAAATATGAACTGTCTGATAATGAGCTGGCGGTATTTTACTCAGCTGCCGACCATCGTCTGGCGGAAC
TGACCATGAATAAGCTATACGATAAAATCCCGACCTCTGTCTGGAAATTTATCCGCTAA

Antitoxin


Download         Length: 125 a.a.        Molecular weight: 14368.06 Da        Isoelectric Point: 4.8989

>AT64246 WP_002892066.1 NZ_CP016159:1230349-1230723 [Klebsiella pneumoniae]
MDEYSPKRHDIAQLRFLCETLYHDCLANLEESNHGWVNDPTSAVNLQLNELIEHIATFALNYKIKYAEDNKLIAQVDEYL
DDTFTLFSNYGINSTDLQKWKKSGNRLFRCFVNASRENPASLSC

Download         Length: 375 bp

>AT64246 NZ_CP016159:1230349-1230723 [Klebsiella pneumoniae]
ATGGACGAATACTCGCCAAAAAGACATGATATTGCACAGCTACGCTTTCTCTGCGAAACGCTGTATCATGACTGCCTTGC
AAACCTGGAAGAGAGCAACCATGGCTGGGTCAACGACCCGACGTCGGCTGTCAATCTCCAGTTAAATGAATTGATCGAGC
ACATTGCCACATTCGCTCTTAATTATAAAATTAAGTATGCAGAGGATAATAAGCTGATCGCTCAGGTTGACGAATATCTG
GACGACACTTTTACGTTGTTCAGTAACTACGGCATTAACTCTACGGATTTGCAAAAGTGGAAAAAATCCGGTAACCGACT
ATTTCGTTGCTTTGTCAACGCCAGCCGGGAAAACCCGGCCAGTCTATCGTGTTAG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A2P8K6F2

Antitoxin

Source ID Structure
AlphaFold DB A0A0H3GJ93

References