64243

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) /HTH_XRE(antitoxin)
Location 1676571..1677390 Replicon chromosome
Accession NZ_CP016157
Organism Staphylococcus simulans strain MR2

Toxin (Protein)


Gene name - Uniprot ID -
Locus tag A9958_RS08050 Protein ID WP_106421061.1
Coordinates 1676917..1677390 (+) Length 158 a.a.

Antitoxin (Protein)


Gene name - Uniprot ID -
Locus tag A9958_RS08045 Protein ID WP_105996454.1
Coordinates 1676571..1676903 (+) Length 111 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
A9958_RS07990 1671804..1672250 - 447 WP_106421052.1 single-stranded DNA-binding protein -
A9958_RS07995 1672250..1672921 - 672 WP_106421053.1 ERF family protein -
A9958_RS08000 1672884..1673138 - 255 WP_106421054.1 DUF2483 family protein -
A9958_RS08005 1673131..1673355 - 225 WP_106421055.1 hypothetical protein -
A9958_RS08010 1673455..1673670 - 216 WP_106421056.1 hypothetical protein -
A9958_RS08015 1673683..1673985 - 303 WP_002480770.1 DUF771 domain-containing protein -
A9958_RS08020 1674100..1674423 + 324 WP_106421057.1 hypothetical protein -
A9958_RS13865 1674412..1674570 - 159 WP_159079669.1 hypothetical protein -
A9958_RS08025 1674617..1674844 - 228 WP_106421058.1 hypothetical protein -
A9958_RS08030 1674845..1675618 - 774 WP_106421059.1 phage antirepressor KilAC domain-containing protein -
A9958_RS08035 1675734..1675970 + 237 WP_105976070.1 hypothetical protein -
A9958_RS13960 1675963..1676124 - 162 WP_182477690.1 hypothetical protein -
A9958_RS08040 1676139..1676378 - 240 WP_106421060.1 helix-turn-helix domain-containing protein -
A9958_RS08045 1676571..1676903 + 333 WP_105996454.1 helix-turn-helix domain-containing protein Antitoxin
A9958_RS08050 1676917..1677390 + 474 WP_106421061.1 ImmA/IrrE family metallo-endopeptidase Toxin
A9958_RS08055 1677377..1678018 + 642 WP_105976065.1 DUF4352 domain-containing protein -
A9958_RS13870 1678197..1678337 + 141 WP_158257428.1 hypothetical protein -
A9958_RS08060 1678432..1678947 + 516 WP_106421062.1 hypothetical protein -
A9958_RS08065 1678949..1679257 + 309 WP_106421063.1 hypothetical protein -
A9958_RS08070 1679322..1680350 + 1029 WP_106421064.1 site-specific integrase -
A9958_RS08075 1680362..1680541 - 180 WP_180363558.1 RNA chaperone Hfq -
A9958_RS08080 1680538..1681500 - 963 WP_106421065.1 tRNA (adenosine(37)-N6)-dimethylallyltransferase MiaA -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Prophage - - 1640893..1680350 39457


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

IrrE N-terminal-like domain

(31-118)

Antitoxin

Cro/C1-type helix-turn-helix domain

(10-65)


Sequences

Toxin        


Download         Length: 158 a.a.        Molecular weight: 18576.85 Da        Isoelectric Point: 6.2286

>T64243 WP_106421061.1 NZ_CP016157:1676917-1677390 [Staphylococcus simulans]
MGVYEDLCIANDWVEIEETDRLPSFQPGFYRNGKIYIKSSLSEIRKAEVLYEELAHHKLTYGNILDESSFNNRKFENYAR
RHGYENSISLNKIIDAYKYGVSSLYEFAEYVQLSEEHVYTVLQHYKNKFGLSTCHNGYLIRFEPLQVFKYKKLNEGD

Download         Length: 474 bp

>T64243 NZ_CP016157:1676917-1677390 [Staphylococcus simulans]
ATGGGAGTTTACGAAGATTTATGTATCGCTAACGATTGGGTTGAGATTGAGGAGACTGATCGTTTACCTAGTTTCCAACC
AGGGTTCTACAGAAATGGAAAAATCTATATTAAAAGCAGTCTTTCCGAAATACGAAAAGCTGAAGTTCTCTATGAAGAAT
TAGCTCACCATAAACTTACATACGGAAATATACTTGATGAATCAAGTTTCAATAACCGTAAATTCGAAAATTACGCACGA
AGACATGGTTATGAAAATTCTATATCTTTGAACAAGATTATAGACGCATATAAATACGGAGTAAGTAGCTTATATGAATT
TGCTGAATATGTTCAATTAAGCGAAGAACACGTATATACAGTGTTACAGCATTACAAAAATAAATTCGGTTTATCAACTT
GCCATAACGGCTATCTTATTCGATTTGAGCCATTGCAGGTTTTTAAATATAAAAAATTAAATGAAGGAGATTAG

Antitoxin


Download         Length: 111 a.a.        Molecular weight: 12869.51 Da        Isoelectric Point: 4.7176

>AT64243 WP_105996454.1 NZ_CP016157:1676571-1676903 [Staphylococcus simulans]
MRTNDEIITIIKTTLKEQNMSLSELARRVGMAKSAVSRYLNLTREFPLNRAEDFAKALHISTEYLLGFTESEQKEQEQDT
MAAHFDKEGLTEEEIEEVNKFIEWVKNRDK

Download         Length: 333 bp

>AT64243 NZ_CP016157:1676571-1676903 [Staphylococcus simulans]
ATGAGAACAAATGATGAAATAATCACAATAATAAAAACAACGTTAAAAGAACAAAATATGTCGCTTAGTGAATTAGCTCG
TCGTGTAGGAATGGCTAAATCAGCTGTATCGCGTTATTTAAACTTAACTAGAGAGTTTCCATTGAACCGTGCGGAAGATT
TTGCAAAAGCACTTCATATTAGTACAGAATATTTACTTGGTTTTACAGAAAGTGAACAAAAAGAGCAAGAACAAGACACT
ATGGCCGCTCATTTTGACAAAGAAGGTCTAACAGAAGAGGAAATTGAAGAAGTTAATAAGTTTATTGAATGGGTTAAGAA
TAGAGATAAGTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References