Detailed information of TA system
Bioinformatically predictedOverview
TA module
Type | II | Classification (family/domain) | TsdAT/- |
Location | 835294..835815 | Replicon | chromosome |
Accession | NZ_CP016073 | ||
Organism | Staphylococcus pseudintermedius strain 081661 isolate 20081661 |
Toxin (Protein)
Gene name | TsdT | Uniprot ID | A0A3D8YLE8 |
Locus tag | A9I65_RS03660 | Protein ID | WP_014613364.1 |
Coordinates | 835594..835815 (+) | Length | 74 a.a. |
Antitoxin (Protein)
Gene name | TsdA | Uniprot ID | A0A166R1D0 |
Locus tag | A9I65_RS03655 | Protein ID | WP_014613363.1 |
Coordinates | 835294..835581 (+) | Length | 96 a.a. |
Genomic Context
Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
---|---|---|---|---|---|---|
A9I65_RS03630 | 830555..831358 | + | 804 | WP_014613358.1 | hydroxyethylthiazole kinase | - |
A9I65_RS03635 | 831348..831986 | + | 639 | WP_014613359.1 | thiamine phosphate synthase | - |
A9I65_RS03640 | 832075..832941 | + | 867 | WP_014613360.1 | membrane protein insertase YidC | - |
A9I65_RS03645 | 832995..833651 | - | 657 | WP_014613361.1 | HD domain-containing protein | - |
A9I65_RS03650 | 833672..835162 | - | 1491 | WP_014613362.1 | cardiolipin synthase | - |
A9I65_RS03655 | 835294..835581 | + | 288 | WP_014613363.1 | copper-sensing transcriptional repressor CsoR | Antitoxin |
A9I65_RS03660 | 835594..835815 | + | 222 | WP_014613364.1 | heavy-metal-associated domain-containing protein | Toxin |
A9I65_RS03665 | 835819..836025 | + | 207 | WP_014613365.1 | cation transporter | - |
A9I65_RS03670 | 836126..838306 | + | 2181 | WP_037542539.1 | heavy metal translocating P-type ATPase | - |
A9I65_RS13710 | 838392..838538 | + | 147 | WP_014613367.1 | hypothetical protein | - |
Associated MGEs
MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
---|
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 74 a.a. Molecular weight: 8065.10 Da Isoelectric Point: 4.3480
>T64207 WP_014613364.1 NZ_CP016073:835594-835815 [Staphylococcus pseudintermedius]
MENGYVKVTQLTTEAQQQQLSDRLLRLIGVESVAIDVATQSLTLTYDTPANLNTIEKEIYDAGFPVIQSHKGV
MENGYVKVTQLTTEAQQQQLSDRLLRLIGVESVAIDVATQSLTLTYDTPANLNTIEKEIYDAGFPVIQSHKGV
Download Length: 222 bp
>T64207 NZ_CP016073:835594-835815 [Staphylococcus pseudintermedius]
ATGGAAAATGGTTATGTTAAAGTAACACAACTGACAACTGAAGCACAGCAACAACAGCTATCTGATCGTTTGCTTCGTTT
AATTGGTGTCGAGTCTGTTGCTATTGATGTGGCAACACAATCGTTGACGCTCACTTATGACACGCCAGCAAATTTGAACA
CGATAGAAAAAGAAATTTATGATGCAGGATTTCCTGTTATCCAATCACATAAAGGAGTGTAA
ATGGAAAATGGTTATGTTAAAGTAACACAACTGACAACTGAAGCACAGCAACAACAGCTATCTGATCGTTTGCTTCGTTT
AATTGGTGTCGAGTCTGTTGCTATTGATGTGGCAACACAATCGTTGACGCTCACTTATGACACGCCAGCAAATTTGAACA
CGATAGAAAAAGAAATTTATGATGCAGGATTTCCTGTTATCCAATCACATAAAGGAGTGTAA
Antitoxin
Download Length: 96 a.a. Molecular weight: 10997.59 Da Isoelectric Point: 7.0504
>AT64207 WP_014613363.1 NZ_CP016073:835294-835581 [Staphylococcus pseudintermedius]
MTEQAHHSEEIKRNLKSRLNRIEGQVKAINRMIDEDVYCDDVLTQIRATRSALNSVASRLLDHHMKGCIKHKIDAGHQDE
AMEELLVTFQKLMKD
MTEQAHHSEEIKRNLKSRLNRIEGQVKAINRMIDEDVYCDDVLTQIRATRSALNSVASRLLDHHMKGCIKHKIDAGHQDE
AMEELLVTFQKLMKD
Download Length: 288 bp
>AT64207 NZ_CP016073:835294-835581 [Staphylococcus pseudintermedius]
ATGACTGAACAAGCACATCATTCTGAAGAAATTAAACGTAACTTGAAGTCGCGTTTGAATCGTATTGAAGGCCAAGTGAA
AGCAATCAACCGAATGATTGACGAAGATGTCTATTGTGATGACGTGTTGACGCAAATTAGAGCGACACGTTCGGCTTTAA
ACAGTGTGGCGTCGCGTCTGTTAGATCATCATATGAAAGGATGCATCAAGCATAAGATTGACGCGGGACACCAAGACGAA
GCGATGGAAGAGTTATTAGTAACATTTCAAAAACTCATGAAAGATTAG
ATGACTGAACAAGCACATCATTCTGAAGAAATTAAACGTAACTTGAAGTCGCGTTTGAATCGTATTGAAGGCCAAGTGAA
AGCAATCAACCGAATGATTGACGAAGATGTCTATTGTGATGACGTGTTGACGCAAATTAGAGCGACACGTTCGGCTTTAA
ACAGTGTGGCGTCGCGTCTGTTAGATCATCATATGAAAGGATGCATCAAGCATAAGATTGACGCGGGACACCAAGACGAA
GCGATGGAAGAGTTATTAGTAACATTTCAAAAACTCATGAAAGATTAG
Similar Proteins
Only experimentally validated proteins are listed.
Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
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Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
---|
Structures
Toxin
Source | ID | Structure |
---|---|---|
AlphaFold DB | A0A3D8YLE8 |
Antitoxin
Source | ID | Structure |
---|---|---|
AlphaFold DB | A0A166R1D0 |