Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) cptAB/Cpta(toxin)
Location 3266504..3267167 Replicon chromosome
Accession NZ_CP016044
Organism Edwardsiella piscicida strain S11-285

Toxin (Protein)


Gene name cptA Uniprot ID A0A411H3S7
Locus tag A9797_RS14590 Protein ID WP_034167931.1
Coordinates 3266504..3266920 (-) Length 139 a.a.

Antitoxin (Protein)


Gene name cptB Uniprot ID D0ZDY6
Locus tag A9797_RS14595 Protein ID WP_012849755.1
Coordinates 3266901..3267167 (-) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
A9797_RS14570 3262435..3264168 - 1734 WP_069579299.1 single-stranded-DNA-specific exonuclease RecJ -
A9797_RS14575 3264173..3264889 - 717 WP_015462274.1 bifunctional protein-disulfide isomerase/oxidoreductase DsbC -
A9797_RS14580 3264917..3265816 - 900 WP_012849752.1 site-specific tyrosine recombinase XerD -
A9797_RS14585 3265967..3266479 + 513 WP_012849753.1 flavodoxin FldB -
A9797_RS14590 3266504..3266920 - 417 WP_034167931.1 protein YgfX Toxin
A9797_RS14595 3266901..3267167 - 267 WP_012849755.1 FAD assembly factor SdhE Antitoxin
A9797_RS14600 3267515..3268513 + 999 WP_069579301.1 tRNA-modifying protein YgfZ -
A9797_RS14605 3268556..3269380 - 825 WP_069579303.1 shikimate 5-dehydrogenase -
A9797_RS14610 3269539..3270411 - 873 WP_012849758.1 nucleoside-specific channel-forming protein Tsx -
A9797_RS14615 3271020..3271670 + 651 WP_069579679.1 hemolysin III family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Inner membrane protein YgfX

(3-131)

Antitoxin

Flavinator of succinate dehydrogenase

(7-79)


Sequences

Toxin        


Download         Length: 139 a.a.        Molecular weight: 16213.03 Da        Isoelectric Point: 11.6049

>T64202 WP_034167931.1 NZ_CP016044:c3266920-3266504 [Edwardsiella piscicida]
VVLWRCNVHVSWRTQVMFLLGHGALVLAILLAPWPENYSVFWLILLVAVIFECIRSQRRIARNRGELQLLAPQVWHWQLR
EWRLARRPWVSDLGALLILQSTHGAPCRRRLWLAADSMSREEWGQLRRTLLDAGDDRA

Download         Length: 417 bp

>T64202 NZ_CP016044:c3266920-3266504 [Edwardsiella piscicida]
GTGGTCCTTTGGCGCTGTAATGTTCACGTCTCCTGGCGTACCCAGGTGATGTTTCTGCTGGGGCACGGCGCGCTGGTACT
GGCGATCCTGCTGGCGCCCTGGCCGGAAAACTACAGCGTATTCTGGCTGATTCTGCTGGTGGCGGTGATCTTTGAGTGTA
TCCGCAGCCAGCGCCGGATTGCGCGTAACCGCGGTGAGCTGCAGCTGCTGGCGCCGCAGGTGTGGCACTGGCAGCTGCGC
GAGTGGCGCCTGGCCCGACGCCCTTGGGTTAGCGATCTGGGGGCGCTGCTGATCCTGCAGAGTACCCATGGTGCGCCGTG
CCGCCGCCGTCTGTGGCTGGCGGCCGACAGCATGAGCCGCGAAGAGTGGGGGCAGCTGCGCCGCACGCTGCTCGATGCGG
GCGACGATCGCGCATAG

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 10318.90 Da        Isoelectric Point: 5.6951

>AT64202 WP_012849755.1 NZ_CP016044:c3267167-3266901 [Edwardsiella piscicida]
MDINNKARVHWACRRGMRELDIAIMPFFEHEYDALNDADKQTFVRLLACDDPELFKWLMNQGKPDDADLARMITLIQTRN
KERGPLAL

Download         Length: 267 bp

>AT64202 NZ_CP016044:c3267167-3266901 [Edwardsiella piscicida]
ATGGATATCAATAATAAAGCGCGGGTTCACTGGGCGTGCCGCCGCGGAATGCGCGAGCTGGATATCGCCATCATGCCTTT
CTTTGAACATGAGTATGATGCGCTTAACGATGCCGATAAACAGACCTTTGTCCGCCTGCTGGCCTGTGACGATCCTGAGC
TATTTAAATGGCTGATGAACCAGGGTAAGCCGGATGACGCCGATCTGGCCCGCATGATTACGCTGATTCAGACGCGAAAT
AAAGAACGTGGTCCTTTGGCGCTGTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A411H3S7

Antitoxin

Source ID Structure
AlphaFold DB A0A034T2Q8

References