Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) Hha-TomB/-
Location 1132437..1133029 Replicon chromosome
Accession NZ_CP016044
Organism Edwardsiella piscicida strain S11-285

Toxin (Protein)


Gene name Hha Uniprot ID D0ZEC2
Locus tag A9797_RS04975 Protein ID WP_012847872.1
Coordinates 1132437..1132640 (-) Length 68 a.a.

Antitoxin (Protein)


Gene name TomB Uniprot ID A0A411GZW1
Locus tag A9797_RS04980 Protein ID WP_015461125.1
Coordinates 1132661..1133029 (-) Length 123 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
A9797_RS04945 1128143..1128604 + 462 WP_012847865.1 Lrp/AsnC family transcriptional regulator -
A9797_RS04950 1128909..1129247 + 339 WP_069578328.1 P-II family nitrogen regulator -
A9797_RS04955 1129269..1130549 + 1281 WP_041692495.1 ammonium transporter AmtB -
A9797_RS04960 1130584..1131450 - 867 WP_012847869.1 acyl-CoA thioesterase II -
A9797_RS04965 1131559..1131836 - 278 Protein_971 MGMT family protein -
A9797_RS04975 1132437..1132640 - 204 WP_012847872.1 hemolysin expression modulator Hha Toxin
A9797_RS04980 1132661..1133029 - 369 WP_015461125.1 Hha toxicity modulator TomB Antitoxin
A9797_RS04985 1133397..1136549 - 3153 WP_012847874.1 multidrug efflux RND transporter permease subunit -
A9797_RS04990 1136593..1137777 - 1185 WP_012847875.1 efflux RND transporter periplasmic adaptor subunit -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Haemolysin expression modulating, HHA

(8-64)

Antitoxin

Biofilm formation regulator YbaJ

(1-115)


Sequences

Toxin        


Download         Length: 68 a.a.        Molecular weight: 8103.37 Da        Isoelectric Point: 5.0914

>T64182 WP_012847872.1 NZ_CP016044:c1132640-1132437 [Edwardsiella piscicida]
MTKIDYLMKLRKCTTLDTLERVIEKNKYELSDDELEIFYSAADHRLAELTMNKLYDKIPAEVWQYVR

Download         Length: 204 bp

>T64182 NZ_CP016044:c1132640-1132437 [Edwardsiella piscicida]
ATGACCAAGATCGATTATCTGATGAAGCTGCGTAAATGCACGACGCTGGATACTCTAGAACGCGTGATCGAAAAGAATAA
ATACGAACTTTCAGATGATGAATTAGAAATTTTTTATTCTGCCGCAGATCATCGTCTGGCCGAATTAACTATGAATAAGC
TATACGACAAAATTCCAGCAGAAGTCTGGCAATACGTCCGCTAA

Antitoxin


Download         Length: 123 a.a.        Molecular weight: 14099.80 Da        Isoelectric Point: 6.1484

>AT64182 WP_015461125.1 NZ_CP016044:c1133029-1132661 [Edwardsiella piscicida]
MDEYTSYQHDIAELKYLCDSLYHQGIDVLGESHHGWVSDPTAKVNLQLNELIEHIASVAQSFKIKYPHHSDLAEILDDYL
DETYALFGAYSVSETALRHWLRTKRRVAYCLAHEKRNAALHV

Download         Length: 369 bp

>AT64182 NZ_CP016044:c1133029-1132661 [Edwardsiella piscicida]
ATGGATGAGTACACTTCTTATCAGCATGACATCGCAGAGTTAAAATACCTGTGTGATTCTCTGTATCATCAGGGAATAGA
TGTCCTGGGAGAGAGCCATCACGGCTGGGTCAGCGACCCGACGGCAAAGGTAAATCTACAGCTTAATGAGCTGATTGAGC
ATATTGCCAGCGTCGCGCAATCATTTAAGATCAAATATCCGCATCATTCGGATTTAGCCGAAATATTGGATGATTATCTG
GATGAAACCTATGCCCTGTTTGGCGCCTATAGCGTCAGTGAAACGGCGCTCCGGCACTGGCTGCGCACCAAGCGGCGGGT
GGCATACTGCCTGGCGCATGAAAAGCGCAACGCTGCCTTACATGTTTAG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A034SMG4

Antitoxin

Source ID Structure
AlphaFold DB A0A411GZW1

References