64169

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) cptAB/Cpta(toxin)
Location 570111..570780 Replicon chromosome
Accession NZ_CP016043
Organism Edwardsiella hoshinae strain ATCC 35051

Toxin (Protein)


Gene name cptA Uniprot ID A0A376D7Q3
Locus tag A9798_RS02515 Protein ID WP_024524368.1
Coordinates 570358..570780 (+) Length 141 a.a.

Antitoxin (Protein)


Gene name cptB Uniprot ID A0A376D8K0
Locus tag A9798_RS02510 Protein ID WP_024524369.1
Coordinates 570111..570377 (+) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
A9798_RS02490 565512..566162 - 651 WP_024524373.1 hemolysin III family protein -
A9798_RS02495 566736..567611 + 876 WP_024524372.1 nucleoside-specific channel-forming protein Tsx -
A9798_RS02500 567839..568663 + 825 WP_070244513.1 shikimate 5-dehydrogenase -
A9798_RS02505 568715..569710 - 996 WP_024524370.1 tRNA-modifying protein YgfZ -
A9798_RS02510 570111..570377 + 267 WP_024524369.1 FAD assembly factor SdhE Antitoxin
A9798_RS02515 570358..570780 + 423 WP_024524368.1 protein YgfX Toxin
A9798_RS02520 570871..571389 - 519 WP_070244514.1 flavodoxin FldB -
A9798_RS02525 571535..572434 + 900 WP_024524366.1 site-specific tyrosine recombinase XerD -
A9798_RS02530 572462..573178 + 717 WP_024524365.1 bifunctional protein-disulfide isomerase/oxidoreductase DsbC -
A9798_RS02535 573183..574916 + 1734 WP_024524364.1 single-stranded-DNA-specific exonuclease RecJ -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Inner membrane protein YgfX

(3-135)

Antitoxin

Flavinator of succinate dehydrogenase

(7-79)


Sequences

Toxin        


Download         Length: 141 a.a.        Molecular weight: 16237.92 Da        Isoelectric Point: 9.8771

>T64169 WP_024524368.1 NZ_CP016043:570358-570780 [Edwardsiella hoshinae]
VAPWCCNIHVSWRTQVIALLGYGALVLAILLAPWPESYGVSAIWLVLLVAVIFECIRSQRRIARNRGELQYHATGEWRWQ
QREWRLARRPWISDMGVLLLLQSCTGPARRRRLWLAADSMSRDEWSELRALLLNTRGADD

Download         Length: 423 bp

>T64169 NZ_CP016043:570358-570780 [Edwardsiella hoshinae]
GTGGCCCCATGGTGCTGTAATATCCATGTCTCCTGGCGTACCCAGGTGATCGCATTGCTGGGATATGGCGCGTTGGTGCT
GGCGATTCTCTTGGCCCCTTGGCCGGAGAGTTATGGCGTCAGCGCCATCTGGCTGGTGCTGCTGGTGGCGGTGATCTTCG
AGTGTATCCGCAGCCAGCGTCGGATCGCGCGCAATCGTGGGGAACTGCAATACCACGCGACGGGAGAGTGGCGTTGGCAA
CAGCGTGAATGGCGTCTAGCCCGCCGCCCGTGGATCAGCGATATGGGGGTGTTGCTGCTGTTGCAAAGCTGTACGGGGCC
GGCGCGTCGGCGACGCCTGTGGTTGGCCGCAGACAGCATGAGCCGCGACGAGTGGAGTGAATTACGCGCGCTATTACTGA
ACACCCGCGGCGCAGACGACTAG

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 10445.11 Da        Isoelectric Point: 5.6981

>AT64169 WP_024524369.1 NZ_CP016043:570111-570377 [Edwardsiella hoshinae]
MDINNKARVHWACRRGMRELDIAIMPFFEHEYETMSDADKQTFVRLLSYDDPELFKWLMNQGVPEDVELARMITLIQTRN
KARGPMVL

Download         Length: 267 bp

>AT64169 NZ_CP016043:570111-570377 [Edwardsiella hoshinae]
ATGGATATCAATAATAAAGCACGGGTTCACTGGGCATGTCGCCGTGGCATGCGGGAGTTGGACATCGCCATTATGCCCTT
CTTCGAGCATGAATATGAGACGATGAGCGATGCCGATAAGCAGACGTTTGTCCGCCTGTTGAGCTATGACGATCCCGAGT
TATTCAAGTGGTTGATGAACCAAGGCGTACCGGAGGATGTTGAGCTGGCACGAATGATTACCCTGATTCAGACGCGAAAT
AAAGCACGTGGCCCCATGGTGCTGTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A376D7Q3

Antitoxin

Source ID Structure
AlphaFold DB A0A376D8K0

References