Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/ParE-YafN
Location 6683..7211 Replicon plasmid unnamed
Accession NZ_CP016031
Organism Legionella pneumophila strain OLDA

Toxin (Protein)


Gene name relE Uniprot ID A0A0A8UYT5
Locus tag A9P84_RS15545 Protein ID WP_011212544.1
Coordinates 6924..7211 (+) Length 96 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID A0A0A8UU85
Locus tag A9P84_RS15540 Protein ID WP_011212545.1
Coordinates 6683..6934 (+) Length 84 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
A9P84_RS15515 2372..3253 + 882 WP_021436862.1 hypothetical protein -
A9P84_RS15520 3541..4119 + 579 WP_010655397.1 nucleotidyltransferase domain-containing protein -
A9P84_RS15525 4106..4543 + 438 WP_010655396.1 DNA-binding protein -
A9P84_RS15530 4527..5348 + 822 WP_011212547.1 DUF4111 domain-containing protein -
A9P84_RS15535 5967..6434 + 468 WP_011212546.1 hypothetical protein -
A9P84_RS15540 6683..6934 + 252 WP_011212545.1 type II toxin-antitoxin system prevent-host-death family antitoxin Antitoxin
A9P84_RS15545 6924..7211 + 288 WP_011212544.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
A9P84_RS15550 7424..8185 + 762 WP_011212543.1 MerR family transcriptional regulator -
A9P84_RS15555 8243..9118 + 876 WP_011212542.1 alpha/beta hydrolase -
A9P84_RS15560 9212..9394 - 183 WP_011212541.1 hypothetical protein -
A9P84_RS15565 9450..9761 - 312 WP_011212540.1 hypothetical protein -
A9P84_RS15570 9770..10345 - 576 WP_011212539.1 pyridoxamine 5'-phosphate oxidase family protein -
A9P84_RS15575 10396..11904 - 1509 WP_011212538.1 DUF3987 domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Non-Mobilizable plasmid blaOXA-29 - 1..129884 129884


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(6-84)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(8-68)


Sequences

Toxin        


Download         Length: 96 a.a.        Molecular weight: 11302.35 Da        Isoelectric Point: 10.4380

>T64168 WP_011212544.1 NZ_CP016031:6924-7211 [Legionella pneumophila]
MIYELHFHPLALKEWKKLSKELQEQFKKLLKRRLENPHVISAKLSGHLKDCYKIKLHQAGYRLVYQVNDNKMILLVVAVG
KRNKNKVYESAEDRT

Download         Length: 288 bp

>T64168 NZ_CP016031:6924-7211 [Legionella pneumophila]
ATGATCTATGAGTTACATTTCCATCCGCTTGCGTTAAAAGAATGGAAGAAACTATCGAAGGAGTTGCAGGAACAGTTTAA
AAAACTATTAAAACGGCGACTGGAAAATCCGCATGTTATTTCTGCCAAACTTAGTGGCCATCTTAAAGATTGCTATAAGA
TAAAATTGCATCAGGCCGGCTATAGATTGGTCTACCAAGTTAACGATAATAAAATGATTCTCCTTGTTGTTGCTGTAGGC
AAGCGAAACAAAAATAAAGTCTATGAGTCAGCAGAAGATAGGACTTAA

Antitoxin


Download         Length: 84 a.a.        Molecular weight: 9165.58 Da        Isoelectric Point: 4.5164

>AT64168 WP_011212545.1 NZ_CP016031:6683-6934 [Legionella pneumophila]
MQTLYATQVASISELKKNPTKLINDAHGMPVVILNHNVAAAYLIPAETFEKLMDAVDESELKSIVEQRLSEPFTPVKVAL
DDL

Download         Length: 252 bp

>AT64168 NZ_CP016031:6683-6934 [Legionella pneumophila]
ATGCAAACTTTATATGCAACACAAGTCGCTAGCATTAGCGAATTAAAGAAAAATCCCACAAAACTTATTAATGATGCTCA
TGGGATGCCCGTGGTGATTCTTAACCATAATGTAGCTGCTGCTTATTTAATTCCAGCAGAAACTTTTGAAAAACTGATGG
ATGCTGTTGACGAAAGCGAGCTAAAAAGCATTGTAGAACAACGCCTTTCAGAGCCCTTTACGCCAGTTAAGGTTGCGCTT
GATGATCTATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0A8UYT5

Antitoxin

Source ID Structure
AlphaFold DB A0A0A8UU85

References