Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) mazEF/MazF-MazE
Location 204064..204626 Replicon plasmid pRI-1
Accession NZ_CP016024
Organism Ralstonia insidiosa strain ATCC 49129

Toxin (Protein)


Gene name mazE Uniprot ID -
Locus tag A9Y76_RS28000 Protein ID WP_024979632.1
Coordinates 204064..204384 (-) Length 107 a.a.

Antitoxin (Protein)


Gene name mazF Uniprot ID -
Locus tag A9Y76_RS28005 Protein ID WP_024979631.1
Coordinates 204378..204626 (-) Length 83 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
A9Y76_RS27960 200293..200733 - 441 WP_024979640.1 hypothetical protein -
A9Y76_RS27965 200819..201079 - 261 WP_048932975.1 hypothetical protein -
A9Y76_RS27970 201213..201569 - 357 WP_024979638.1 hypothetical protein -
A9Y76_RS27975 201584..201829 - 246 WP_024979637.1 hypothetical protein -
A9Y76_RS27980 201933..202286 - 354 WP_024979636.1 hypothetical protein -
A9Y76_RS30240 202775..202954 - 180 WP_112189119.1 hypothetical protein -
A9Y76_RS27995 203157..203783 - 627 WP_024979633.1 hypothetical protein -
A9Y76_RS28000 204064..204384 - 321 WP_024979632.1 type II toxin-antitoxin system PemK/MazF family toxin Toxin
A9Y76_RS28005 204378..204626 - 249 WP_024979631.1 antitoxin Antitoxin
A9Y76_RS28010 204928..205317 + 390 WP_024979630.1 hypothetical protein -
A9Y76_RS28015 205314..206018 - 705 WP_024979629.1 SOS response-associated peptidase family protein -
A9Y76_RS28020 206163..206501 - 339 WP_152543766.1 hypothetical protein -
A9Y76_RS28025 206763..207533 - 771 WP_024979627.1 PRTRC system ThiF family protein -
A9Y76_RS28030 207523..208161 - 639 WP_024979626.1 PRTRC system protein A -
A9Y76_RS28035 208161..208904 - 744 WP_024979625.1 PRTRC system protein B -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Non-Mobilizable plasmid - - 1..317936 317936


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase PemK-like

(4-104)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 107 a.a.        Molecular weight: 11724.93 Da        Isoelectric Point: 10.5593

>T64158 WP_024979632.1 NZ_CP016024:c204384-204064 [Ralstonia insidiosa]
VVARGDIWLVALDPTKGSEIQKTRPCVVVSPPEMHDHLRTVIVAPMTSKGRPAPFRVPITFLRKSGLILLDQIRAVDKVR
LVKKEGVVADKTMLSALQTLQEVFAE

Download         Length: 321 bp

>T64158 NZ_CP016024:c204384-204064 [Ralstonia insidiosa]
GTGGTAGCGCGCGGAGATATCTGGCTCGTCGCCCTGGATCCGACAAAAGGAAGTGAGATCCAAAAGACCCGTCCGTGTGT
GGTCGTCTCGCCTCCCGAGATGCACGATCACCTGCGCACTGTCATCGTTGCCCCGATGACTAGCAAAGGCCGCCCCGCAC
CGTTCCGTGTACCGATCACCTTCCTGCGCAAGAGTGGACTGATCCTGCTGGACCAGATACGCGCTGTGGATAAGGTGCGC
CTCGTTAAGAAAGAGGGCGTTGTTGCCGATAAAACGATGTTGAGCGCCCTGCAGACTTTGCAGGAAGTTTTCGCCGAATA
G

Antitoxin


Download         Length: 83 a.a.        Molecular weight: 8946.20 Da        Isoelectric Point: 4.3525

>AT64158 WP_024979631.1 NZ_CP016024:c204626-204378 [Ralstonia insidiosa]
MKATIRRMGNSQGVLIPKPILAQLGLEDEVDMAVEDDALVIRKPKKKPREGWAEASHAVAAADDDVLVMGEFSNADDAEL
TW

Download         Length: 249 bp

>AT64158 NZ_CP016024:c204626-204378 [Ralstonia insidiosa]
ATGAAAGCAACGATTCGCAGGATGGGCAATTCACAGGGGGTCTTGATCCCCAAGCCCATTCTTGCCCAGCTGGGTTTGGA
GGATGAAGTGGACATGGCAGTGGAGGACGATGCTTTGGTGATTCGCAAGCCGAAGAAGAAGCCGCGCGAGGGGTGGGCCG
AGGCCAGCCACGCTGTCGCTGCAGCTGATGATGATGTGCTCGTGATGGGCGAATTCTCCAACGCAGATGACGCGGAGCTG
ACGTGGTAG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References