Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) PumAB/COG3657-dnstrm_HI1420
Location 1375187..1375778 Replicon chromosome
Accession NZ_CP016023
Organism Ralstonia insidiosa strain ATCC 49129

Toxin (Protein)


Gene name PumA Uniprot ID S9S4M8
Locus tag A9Y76_RS24575 Protein ID WP_021193282.1
Coordinates 1375187..1375483 (+) Length 99 a.a.

Antitoxin (Protein)


Gene name PumB Uniprot ID A0A192A5U1
Locus tag A9Y76_RS24580 Protein ID WP_064808401.1
Coordinates 1375485..1375778 (+) Length 98 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
A9Y76_RS24550 1370545..1371165 + 621 WP_064808392.1 cytochrome c oxidase subunit 3 -
A9Y76_RS24555 1371162..1371854 + 693 WP_064808394.1 heme-copper oxidase subunit III family protein -
A9Y76_RS24560 1371863..1372213 + 351 WP_064808397.1 cytochrome C oxidase subunit IV family protein -
A9Y76_RS24565 1372364..1373677 + 1314 WP_104577571.1 MFS transporter -
A9Y76_RS24570 1373668..1374906 - 1239 WP_064808399.1 cystathionine gamma-synthase family protein -
A9Y76_RS24575 1375187..1375483 + 297 WP_021193282.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
A9Y76_RS24580 1375485..1375778 + 294 WP_064808401.1 putative addiction module antidote protein Antitoxin
A9Y76_RS24585 1376036..1379242 + 3207 WP_064808403.1 efflux RND transporter permease subunit -
A9Y76_RS24590 1379235..1380539 + 1305 WP_064808405.1 efflux RND transporter periplasmic adaptor subunit -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Addiction module killer protein, predicted

(3-96)

Antitoxin

Uncharacterized protein HI1420

(4-92)


Sequences

Toxin        


Download         Length: 99 a.a.        Molecular weight: 11051.68 Da        Isoelectric Point: 10.4496

>T64156 WP_021193282.1 NZ_CP016023:1375187-1375483 [Ralstonia insidiosa]
VIELKQTETFRKWRTKLKDERARAAIALRLARLGYGHVGDAEPVGQGISELRIHYGPGYRIYFHQRGSTIVILLCGGDKS
TQAKDINTAKRLAAQWSE

Download         Length: 297 bp

>T64156 NZ_CP016023:1375187-1375483 [Ralstonia insidiosa]
GTGATCGAGCTCAAGCAAACCGAGACGTTCCGAAAGTGGCGCACAAAGCTCAAGGACGAGCGCGCTCGCGCTGCCATCGC
CTTGCGGTTGGCCCGTTTGGGTTATGGCCACGTTGGCGATGCCGAACCGGTCGGACAAGGCATTAGTGAGCTGCGCATCC
ACTACGGGCCTGGATATCGCATTTATTTCCATCAGCGAGGCAGCACGATCGTTATCCTGCTTTGCGGTGGTGATAAAAGC
ACGCAGGCCAAGGACATCAACACGGCCAAGCGCCTCGCTGCGCAATGGAGCGAATGA

Antitoxin


Download         Length: 98 a.a.        Molecular weight: 10400.75 Da        Isoelectric Point: 4.7124

>AT64156 WP_064808401.1 NZ_CP016023:1375485-1375778 [Ralstonia insidiosa]
MTDKLTTYDPAEDLTSDEAIATFMAGAFETNDAGFISHALGIVARAKGMAQIANDTGLSREQLYRSFSEQGNPTLKTLLA
VMQALGIELTTKVHVAH

Download         Length: 294 bp

>AT64156 NZ_CP016023:1375485-1375778 [Ralstonia insidiosa]
ATGACCGACAAGTTGACGACCTATGATCCGGCTGAGGATCTGACCTCTGACGAAGCCATCGCCACGTTCATGGCCGGCGC
ATTCGAAACCAACGATGCTGGCTTCATCTCGCATGCGCTGGGAATCGTCGCCCGCGCCAAAGGCATGGCACAGATCGCCA
ATGACACCGGTCTTTCCCGCGAACAGCTCTATCGCTCATTCAGTGAGCAGGGCAACCCCACATTGAAGACCTTGCTGGCT
GTCATGCAAGCGCTCGGTATTGAATTGACGACCAAGGTCCACGTTGCCCACTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A117DRY5

Antitoxin

Source ID Structure
AlphaFold DB A0A192A5U1

References