Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/RelE-HTH_XRE
Location 929241..929872 Replicon chromosome
Accession NZ_CP016023
Organism Ralstonia insidiosa strain ATCC 49129

Toxin (Protein)


Gene name relE Uniprot ID A0A192A4I6
Locus tag A9Y76_RS22560 Protein ID WP_064807791.1
Coordinates 929241..929498 (+) Length 86 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID A0A192A497
Locus tag A9Y76_RS22565 Protein ID WP_064807793.1
Coordinates 929495..929872 (+) Length 126 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
A9Y76_RS22535 924739..925494 - 756 WP_064807781.1 DUF3348 domain-containing protein -
A9Y76_RS22540 925733..926290 + 558 WP_064807783.1 hypothetical protein -
A9Y76_RS22545 926412..927527 + 1116 WP_151180570.1 class I SAM-dependent methyltransferase -
A9Y76_RS22550 927548..928810 - 1263 WP_064807787.1 TIGR03862 family flavoprotein -
A9Y76_RS22555 928919..929116 - 198 WP_082932935.1 hypothetical protein -
A9Y76_RS22560 929241..929498 + 258 WP_064807791.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
A9Y76_RS22565 929495..929872 + 378 WP_064807793.1 helix-turn-helix transcriptional regulator Antitoxin
A9Y76_RS22570 929883..930731 + 849 WP_064809070.1 SAM-dependent methyltransferase -
A9Y76_RS29435 930738..930875 + 138 Protein_810 NADPH-dependent 7-cyano-7-deazaguanine reductase QueF -
A9Y76_RS22575 931115..934660 + 3546 WP_064807796.1 inverse autotransporter beta domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(4-81)

Antitoxin

Cro/C1-type helix-turn-helix domain

(66-120)


Sequences

Toxin        


Download         Length: 86 a.a.        Molecular weight: 9398.01 Da        Isoelectric Point: 10.7044

>T64155 WP_064807791.1 NZ_CP016023:929241-929498 [Ralstonia insidiosa]
MHAIEFTKQAAQALKAMPRNVAATIRAKIDPLAVDPYAPNPNAKKLAGREGYRLRVGDWRVLYQIEDGRVVIVVLAIKPR
GGAYQ

Download         Length: 258 bp

>T64155 NZ_CP016023:929241-929498 [Ralstonia insidiosa]
ATGCACGCAATCGAGTTCACGAAGCAAGCTGCACAAGCCCTGAAAGCCATGCCGCGCAATGTCGCAGCAACGATTCGAGC
CAAGATCGATCCACTTGCAGTCGACCCCTATGCGCCAAACCCGAACGCAAAGAAGCTCGCTGGGCGTGAGGGCTACCGGC
TCCGCGTTGGTGACTGGCGTGTGCTGTACCAGATTGAAGATGGCCGCGTTGTGATCGTGGTGCTGGCCATCAAACCGCGC
GGAGGCGCATATCAATGA

Antitoxin


Download         Length: 126 a.a.        Molecular weight: 14065.77 Da        Isoelectric Point: 4.4738

>AT64155 WP_064807793.1 NZ_CP016023:929495-929872 [Ralstonia insidiosa]
MTQIQYIERDGHREFAVVPIELWDRIKHLAEDLDDETLFDQAKAEDDGFRVPAAVVDAELAGDHPVRAWRNYRRMTQDAL
AEATGISKPYLSQIETGQRGGTAELLKKLADALNVPLDLLVDAQH

Download         Length: 378 bp

>AT64155 NZ_CP016023:929495-929872 [Ralstonia insidiosa]
ATGACGCAAATCCAATACATCGAGCGTGATGGACATCGCGAATTTGCCGTGGTGCCCATCGAACTCTGGGACCGTATCAA
GCACCTGGCAGAAGACCTGGACGACGAAACCCTGTTCGACCAAGCCAAGGCCGAAGACGACGGCTTTCGTGTGCCGGCCG
CCGTTGTGGATGCCGAGCTTGCCGGTGATCACCCCGTGCGCGCGTGGCGCAACTACCGGCGCATGACCCAAGATGCCCTG
GCAGAGGCCACCGGTATCAGCAAACCCTATCTCAGCCAGATTGAAACCGGGCAGCGCGGCGGCACAGCCGAACTGCTCAA
GAAGCTGGCCGATGCATTGAACGTGCCCCTCGACCTGCTGGTCGATGCTCAACATTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A192A4I6

Antitoxin

Source ID Structure
AlphaFold DB A0A192A497

References