Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) phd-doc/HTH_IclR(antitoxin)
Location 711613..713355 Replicon chromosome
Accession NZ_CP016023
Organism Ralstonia insidiosa strain ATCC 49129

Toxin (Protein)


Gene name doc Uniprot ID A0A192A3R0
Locus tag A9Y76_RS21530 Protein ID WP_064807462.1
Coordinates 712453..713355 (-) Length 301 a.a.

Antitoxin (Protein)


Gene name phd Uniprot ID S9RYF6
Locus tag A9Y76_RS21525 Protein ID WP_021193940.1
Coordinates 711613..712440 (-) Length 276 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
A9Y76_RS21505 706738..708234 - 1497 WP_064807457.1 aldehyde dehydrogenase -
A9Y76_RS21510 708251..709054 - 804 WP_064807459.1 aspartate dehydrogenase -
A9Y76_RS21515 709087..710814 - 1728 WP_064807460.1 thiamine pyrophosphate-binding protein -
A9Y76_RS21520 710807..711610 - 804 WP_064809051.1 SDR family oxidoreductase -
A9Y76_RS21525 711613..712440 - 828 WP_021193940.1 IclR family transcriptional regulator Antitoxin
A9Y76_RS21530 712453..713355 - 903 WP_064807462.1 alpha/beta hydrolase Toxin
A9Y76_RS21535 713360..713896 - 537 WP_064807464.1 cupin domain-containing protein -
A9Y76_RS21540 713942..714715 - 774 WP_064807465.1 SDR family oxidoreductase -
A9Y76_RS21545 714708..715775 - 1068 WP_064807466.1 aromatic ring-hydroxylating dioxygenase subunit alpha -
A9Y76_RS21550 715860..716165 - 306 WP_082932925.1 hypothetical protein -
A9Y76_RS21555 716624..718162 + 1539 WP_064807470.1 cache domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Alpha/beta hydrolase fold-1

(51-288)

Antitoxin

Transcription regulator IclR, N-terminal

(19-68)


Sequences

Toxin        


Download         Length: 301 a.a.        Molecular weight: 31989.21 Da        Isoelectric Point: 6.6892

>T64154 WP_064807462.1 NZ_CP016023:c713355-712453 [Ralstonia insidiosa]
MSTQAVMSSHPFRVADALAVLGAEFAEHTVAINEQGDRIGFRQWGERGPVVVLLHGISSSAASWLPCAQVLSQTTRVFAW
DAPGYGNSTSLQAPAPRAADYAVRLRAWLAALHVKPDVMVGHSLGALMASAYAANAPAAMQPKCLLLLNPAQGYGQPGQE
QASRTVQAQRLATLDQLGIDGMAESRHAHLLRPDASNEERAWVRWNMKRLNDGGYRQAVAMLSGDDIGAYLRKRPASTLA
RVACGDVDSITPPQGCEALAETFDLPFALVPSAGHASYIDAPEAVAGWIEQAVLSQSRNA

Download         Length: 903 bp

>T64154 NZ_CP016023:c713355-712453 [Ralstonia insidiosa]
ATGAGCACGCAGGCTGTCATGTCCTCCCACCCGTTCCGTGTTGCTGATGCACTTGCCGTGCTCGGCGCCGAGTTTGCCGA
ACACACCGTCGCGATCAACGAGCAAGGCGATCGCATTGGCTTTCGGCAATGGGGTGAGCGCGGGCCGGTGGTGGTGCTGT
TGCATGGCATCAGTTCCAGCGCCGCGTCATGGCTGCCTTGCGCGCAAGTCCTTTCGCAAACCACGCGCGTGTTCGCGTGG
GATGCGCCGGGCTACGGCAATTCGACATCGCTGCAAGCGCCGGCACCCCGCGCGGCTGACTATGCGGTGCGCTTGCGCGC
ATGGCTGGCCGCCCTGCATGTGAAGCCGGATGTGATGGTCGGACATTCGTTGGGCGCGTTGATGGCATCTGCGTATGCAG
CCAATGCACCGGCGGCGATGCAGCCGAAGTGCTTGTTGCTCCTGAACCCGGCACAGGGCTACGGCCAGCCGGGGCAGGAA
CAGGCGTCCCGCACTGTGCAGGCTCAACGTCTTGCAACGCTCGATCAATTGGGCATCGACGGCATGGCGGAATCGCGCCA
CGCGCATCTGCTTCGCCCCGATGCCAGCAACGAAGAGCGCGCCTGGGTGCGCTGGAACATGAAGCGCCTGAACGATGGGG
GCTACCGCCAGGCAGTGGCCATGCTCAGCGGCGACGACATTGGCGCCTATCTGCGCAAGCGCCCGGCATCGACACTCGCT
CGCGTGGCCTGTGGTGATGTTGACAGCATCACGCCGCCGCAAGGCTGCGAAGCCTTGGCCGAGACGTTCGATCTGCCGTT
CGCGCTCGTGCCGTCTGCCGGACACGCTTCCTATATCGATGCACCTGAAGCGGTTGCAGGCTGGATCGAACAAGCCGTCC
TCTCTCAATCCCGAAACGCGTAA

Antitoxin


Download         Length: 276 a.a.        Molecular weight: 30690.43 Da        Isoelectric Point: 6.1475

>AT64154 WP_021193940.1 NZ_CP016023:c712440-711613 [Ralstonia insidiosa]
MSNDLISEDVQEKYIVPGLERGLRLLCEFSHKDRVLSAPELARRLKVPRSTVFRLLTTLEVMGFVERVDGGRDFRLGMAV
LRLGFEYLASLELTELGRPLLDRLRDEIHYPCNLVVRDGRSIVYVAKSVAPTPFTSSVNVGTRLPAHATVLGRVLLADLS
LAELRQLYPEPQLEVFSANTPRTVEELFEMVQRDRDHGYVLQEGFFEANISTIAAPVLDRGGKVVAALGTTIPSPRIEPA
QLDTMIDKVRAAAGELSYLLDYRPASGKVVNLFRE

Download         Length: 828 bp

>AT64154 NZ_CP016023:c712440-711613 [Ralstonia insidiosa]
ATGAGCAACGACCTCATCTCCGAAGACGTGCAGGAAAAGTACATCGTCCCCGGGCTCGAACGGGGCCTGCGCCTGCTGTG
CGAGTTCAGCCACAAAGATCGCGTGCTGTCTGCACCGGAACTGGCGCGCCGGCTGAAGGTGCCGCGCTCGACTGTGTTCC
GTTTGCTCACCACGCTCGAAGTCATGGGCTTTGTGGAGCGTGTCGACGGTGGCCGTGATTTCCGCCTCGGCATGGCGGTG
CTGCGCCTGGGCTTTGAGTACCTTGCCTCGCTGGAGCTGACCGAGCTGGGCCGTCCGCTGCTCGATCGCCTGCGCGATGA
AATCCACTACCCGTGCAACCTCGTGGTGCGCGATGGCCGCTCGATCGTCTATGTGGCGAAATCGGTGGCGCCCACGCCGT
TCACGAGCTCCGTCAATGTCGGCACGCGCCTGCCTGCGCATGCCACCGTGCTGGGCCGCGTGCTGCTGGCGGATCTGTCA
CTGGCTGAGTTGCGCCAGCTCTATCCAGAGCCGCAGCTGGAAGTGTTTTCTGCCAACACGCCGCGCACGGTGGAAGAGCT
GTTCGAGATGGTCCAGCGCGACCGTGACCACGGCTACGTACTGCAAGAGGGCTTCTTCGAAGCCAACATCTCCACAATCG
CCGCACCCGTGCTGGACCGCGGCGGCAAGGTGGTCGCCGCGCTCGGCACGACGATCCCGTCGCCGCGCATCGAGCCCGCC
CAGTTGGACACGATGATCGACAAGGTGCGTGCCGCCGCCGGTGAGTTGTCGTACCTGCTGGACTACCGCCCCGCCAGCGG
CAAGGTCGTCAACCTGTTCCGGGAATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A192A3R0

Antitoxin

Source ID Structure
AlphaFold DB A0A100HS72

References