Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/VapC-StbC
Location 260611..261250 Replicon chromosome
Accession NZ_CP016022
Organism Ralstonia insidiosa strain ATCC 49129

Toxin (Protein)


Gene name vapC Uniprot ID A0A191ZSW6
Locus tag A9Y76_RS01275 Protein ID WP_064801383.1
Coordinates 260611..261027 (-) Length 139 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID A0A191ZSW7
Locus tag A9Y76_RS01280 Protein ID WP_064801385.1
Coordinates 261014..261250 (-) Length 79 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
A9Y76_RS01260 255836..257125 + 1290 WP_021196299.1 dicarboxylate/amino acid:cation symporter -
A9Y76_RS01265 257251..259242 + 1992 WP_064801381.1 sensor histidine kinase -
A9Y76_RS01270 259281..260597 + 1317 WP_021196301.1 sigma-54 dependent transcriptional regulator -
A9Y76_RS01275 260611..261027 - 417 WP_064801383.1 type II toxin-antitoxin system VapC family toxin Toxin
A9Y76_RS01280 261014..261250 - 237 WP_064801385.1 hypothetical protein Antitoxin
A9Y76_RS01285 261384..262121 - 738 WP_064801394.1 YukJ family protein -
A9Y76_RS01290 262255..262809 - 555 WP_021196303.1 TlpA family protein disulfide reductase -
A9Y76_RS01295 262911..263426 - 516 WP_064801396.1 O-acetyl-ADP-ribose deacetylase -
A9Y76_RS01300 263508..264077 + 570 WP_064801399.1 hypothetical protein -
A9Y76_RS01305 264103..264930 - 828 WP_064801401.1 SDR family oxidoreductase -
A9Y76_RS01310 265034..265408 + 375 WP_064801403.1 heavy metal-responsive transcriptional regulator -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(2-123)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 139 a.a.        Molecular weight: 15349.52 Da        Isoelectric Point: 6.6412

>T64153 WP_064801383.1 NZ_CP016022:c261027-260611 [Ralstonia insidiosa]
VYLIDTNVISELRKRDRANPGVLAFFRQAENSEAALYLSAVTVGELRRGVELIRHRGDALQADSLEAWLTSVLTDFARSI
LPIDHDVSQVWGRLRVPHPEHALDKLIAATALIHGLTVVTRNVDDFSGCRVPVLNPFN

Download         Length: 417 bp

>T64153 NZ_CP016022:c261027-260611 [Ralstonia insidiosa]
GTGTATTTGATTGATACCAACGTCATCAGTGAACTTCGCAAGCGCGATCGTGCAAACCCCGGCGTGCTGGCGTTCTTTCG
TCAGGCTGAAAACAGTGAGGCGGCACTGTATCTGTCCGCGGTCACAGTCGGTGAGCTACGACGCGGGGTTGAGTTGATCC
GGCATCGCGGCGATGCCCTGCAAGCAGACTCGCTGGAAGCGTGGTTGACCTCGGTGCTGACTGACTTTGCGCGAAGCATC
CTGCCGATTGATCACGATGTGAGCCAGGTTTGGGGACGCCTTCGCGTGCCGCACCCCGAACACGCCTTGGACAAGCTCAT
TGCGGCGACCGCGCTCATTCACGGGCTCACCGTCGTCACGCGTAATGTCGATGACTTCTCAGGTTGCAGAGTTCCAGTGC
TGAACCCGTTCAACTGA

Antitoxin


Download         Length: 79 a.a.        Molecular weight: 8504.54 Da        Isoelectric Point: 5.0623

>AT64153 WP_064801385.1 NZ_CP016022:c261250-261014 [Ralstonia insidiosa]
MANLIVRNIDESLVQRLRELAAAHGRSAEAEHRDILARALGGTPRKSLAEVLMSMPNVGNDADFARVDDTGESSRVFD

Download         Length: 237 bp

>AT64153 NZ_CP016022:c261250-261014 [Ralstonia insidiosa]
ATGGCAAACCTGATCGTCCGAAACATTGATGAAAGTCTGGTGCAACGCCTGCGCGAATTGGCCGCTGCGCATGGCCGAAG
CGCCGAAGCCGAGCATCGTGACATCCTGGCCCGAGCACTCGGCGGCACGCCACGCAAGAGCCTTGCGGAAGTTCTGATGA
GCATGCCGAACGTGGGCAACGACGCGGACTTCGCCCGCGTCGACGACACCGGAGAAAGCTCGCGTGTATTTGATTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A191ZSW6

Antitoxin

Source ID Structure
AlphaFold DB A0A191ZSW7

References