Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) mazF-pemI/MazF(toxin)
Location 3948104..3948740 Replicon chromosome
Accession NZ_CP016020
Organism Bacillus weihaiensis strain Alg07

Toxin (Protein)


Gene name mazF Uniprot ID A0A1L3MW64
Locus tag A9C19_RS19000 Protein ID WP_072581369.1
Coordinates 3948104..3948454 (-) Length 117 a.a.

Antitoxin (Protein)


Gene name pemI Uniprot ID A0A0M2PIB9
Locus tag A9C19_RS19005 Protein ID WP_026562079.1
Coordinates 3948459..3948740 (-) Length 94 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
A9C19_RS18965 3943453..3944244 - 792 WP_072581362.1 RNA polymerase sigma factor SigB -
A9C19_RS18970 3944210..3944692 - 483 WP_072581363.1 anti-sigma B factor RsbW -
A9C19_RS18975 3944689..3945024 - 336 WP_072581364.1 anti-sigma factor antagonist -
A9C19_RS18980 3945082..3946089 - 1008 WP_072581365.1 PP2C family protein-serine/threonine phosphatase -
A9C19_RS18985 3946100..3946501 - 402 WP_072581366.1 anti-sigma regulatory factor -
A9C19_RS18990 3946504..3946866 - 363 WP_072581367.1 STAS domain-containing protein -
A9C19_RS18995 3946870..3947700 - 831 WP_072581368.1 STAS domain-containing protein -
A9C19_RS19000 3948104..3948454 - 351 WP_072581369.1 type II toxin-antitoxin system endoribonuclease NdoA Toxin
A9C19_RS19005 3948459..3948740 - 282 WP_026562079.1 hypothetical protein Antitoxin
A9C19_RS19010 3949105..3950274 - 1170 WP_072581370.1 alanine racemase -
A9C19_RS19020 3950535..3951554 - 1020 WP_072581372.1 outer membrane lipoprotein carrier protein LolA -
A9C19_RS19025 3952070..3952738 + 669 WP_145925819.1 hypothetical protein -
A9C19_RS19030 3952792..3953151 - 360 WP_072581374.1 holo-ACP synthase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase PemK-like

(4-111)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 117 a.a.        Molecular weight: 13020.01 Da        Isoelectric Point: 4.6805

>T64152 WP_072581369.1 NZ_CP016020:c3948454-3948104 [Bacillus weihaiensis]
MIVKRGDVYFADLSPVVGSEQGGVRPVLIIQNDIGNRFSPTVIIAAITAQIQKAKLPTHVEIDAQRYGFERDSVILLEQI
RTIDKQRLTDKITHLDDEMMDKVDEALQISLGLIDF

Download         Length: 351 bp

>T64152 NZ_CP016020:c3948454-3948104 [Bacillus weihaiensis]
TTGATTGTTAAACGAGGCGACGTTTATTTTGCTGATTTATCACCAGTTGTAGGCTCGGAGCAAGGTGGCGTACGTCCTGT
ATTAATTATCCAAAACGATATCGGAAACCGCTTTAGTCCTACAGTTATTATAGCGGCAATTACGGCCCAAATTCAAAAAG
CAAAATTGCCAACTCATGTTGAAATTGATGCACAGCGTTACGGGTTTGAAAGGGATTCGGTTATCCTTCTAGAACAGATT
CGAACGATTGATAAGCAAAGGCTAACGGATAAGATTACCCATCTTGATGATGAGATGATGGATAAAGTTGACGAAGCCTT
GCAAATAAGCTTAGGACTTATCGATTTTTAA

Antitoxin


Download         Length: 94 a.a.        Molecular weight: 10556.00 Da        Isoelectric Point: 5.8851

>AT64152 WP_026562079.1 NZ_CP016020:c3948740-3948459 [Bacillus weihaiensis]
VSESSATTEILIQLPQALVSELDGLVKQENGNRNELIYQATKMYIRERKKRQIRESMRRGYMEMAKINLNIASEAFLAES
EADHTVERLVSGG

Download         Length: 282 bp

>AT64152 NZ_CP016020:c3948740-3948459 [Bacillus weihaiensis]
GTGTCTGAATCCAGCGCAACAACAGAAATCTTAATTCAGTTACCTCAAGCATTAGTATCAGAATTGGATGGACTAGTAAA
ACAGGAAAACGGAAACAGAAACGAGCTTATTTATCAAGCAACTAAAATGTACATTCGTGAGCGTAAGAAGCGCCAAATTC
GCGAATCTATGAGACGTGGCTACATGGAGATGGCGAAGATTAATTTAAACATTGCATCTGAAGCATTCTTGGCAGAATCT
GAGGCTGACCATACCGTTGAACGCTTAGTAAGCGGGGGTTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A1L3MW64

Antitoxin

Source ID Structure
AlphaFold DB A0A0M2PIB9

References