Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/PIN-RelB
Location 1451070..1451950 Replicon chromosome
Accession NZ_CP016019
Organism Bifidobacterium longum subsp. longum strain AH1206

Toxin (Protein)


Gene name relE Uniprot ID I3B0Q4
Locus tag BL1206_RS06580 Protein ID WP_007057208.1
Coordinates 1451070..1451561 (-) Length 164 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID A0A1D7UPI1
Locus tag BL1206_RS06585 Protein ID WP_069483854.1
Coordinates 1451558..1451950 (-) Length 131 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
BL1206_RS06560 1446152..1447384 + 1233 WP_007056207.1 sensor histidine kinase -
BL1206_RS06565 1447419..1448144 + 726 WP_007056206.1 response regulator transcription factor -
BL1206_RS06570 1448184..1448825 + 642 WP_007052627.1 GNAT family N-acetyltransferase -
BL1206_RS06575 1448915..1451020 + 2106 WP_069483853.1 DUF262 domain-containing protein -
BL1206_RS06580 1451070..1451561 - 492 WP_007057208.1 type II toxin-antitoxin system VapC family toxin Toxin
BL1206_RS06585 1451558..1451950 - 393 WP_069483854.1 type II toxin-antitoxin system RelB/DinJ family antitoxin Antitoxin
BL1206_RS06590 1452095..1454794 - 2700 WP_007057211.1 aconitate hydratase AcnA -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Integrative and Conjugative Element - - 1401892..1471047 69155


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(9-146)

Antitoxin

RelB antitoxin/Antitoxin DinJ

(6-61)


Sequences

Toxin        


Download         Length: 164 a.a.        Molecular weight: 18517.67 Da        Isoelectric Point: 6.2335

>T64151 WP_007057208.1 NZ_CP016019:c1451561-1451070 [Bifidobacterium longum subsp. longum]
MRQSKQVSILCDTNILIYYMLCTPRFIKDVMKLFERCVEREVKLSCASLSLKDVFYITPERFKERFMNDESMVVATTAKL
ILPEVAWSGISKLKELMTIVPIGAEECDLAQSLRHAHNDFEDDLIIAAAQQSGATYVVTYDKKLAKHFPEYCKTPAEIVA
ALA

Download         Length: 492 bp

>T64151 NZ_CP016019:c1451561-1451070 [Bifidobacterium longum subsp. longum]
ATGAGGCAGTCAAAGCAGGTGTCGATCTTGTGCGACACCAATATCCTTATTTATTACATGCTCTGTACGCCTCGGTTCAT
CAAGGATGTCATGAAACTGTTCGAGCGATGCGTCGAGCGGGAGGTAAAGCTGTCCTGTGCGTCACTGTCGCTGAAGGACG
TGTTCTACATCACCCCGGAACGATTCAAAGAACGATTCATGAATGACGAATCCATGGTCGTTGCGACCACCGCCAAGCTG
ATATTGCCGGAGGTGGCATGGTCGGGAATCAGCAAACTCAAGGAGCTCATGACAATCGTGCCGATTGGCGCGGAGGAATG
TGATTTGGCGCAGTCGTTGCGGCACGCGCATAACGATTTCGAGGATGACCTTATTATCGCCGCCGCACAACAATCCGGGG
CCACCTATGTGGTGACGTATGACAAAAAACTAGCCAAGCATTTTCCCGAATATTGCAAAACGCCGGCTGAAATCGTGGCG
GCGCTGGCATAG

Antitoxin


Download         Length: 131 a.a.        Molecular weight: 15128.24 Da        Isoelectric Point: 5.7702

>AT64151 WP_069483854.1 NZ_CP016019:c1451950-1451558 [Bifidobacterium longum subsp. longum]
MTMVQMNVRIDAKLKNEVEEVLKGKGVSVSDVIRSLWLYIADRKEVPALETTAEEQAREAEKQRKLKLIREGAGYVHKEL
VKAGLISEDTDLMEGLTYKQFHDEIADERLKEYRHQSDYARYLEKERSLS

Download         Length: 393 bp

>AT64151 NZ_CP016019:c1451950-1451558 [Bifidobacterium longum subsp. longum]
ATGACCATGGTCCAAATGAACGTTCGCATTGATGCGAAACTGAAGAACGAGGTCGAAGAAGTCCTCAAGGGCAAAGGCGT
ATCGGTGAGTGACGTAATCCGGTCGCTGTGGTTGTACATCGCCGACCGCAAGGAAGTGCCGGCATTGGAAACGACCGCCG
AAGAGCAGGCCCGCGAGGCGGAAAAGCAGCGCAAGCTGAAACTGATTCGAGAAGGTGCCGGATACGTGCACAAGGAACTG
GTCAAGGCCGGACTGATCTCAGAAGACACCGACCTCATGGAAGGCCTTACCTACAAGCAGTTCCACGATGAGATAGCTGA
CGAACGGCTGAAGGAATACAGGCATCAGTCGGACTATGCGCGTTATTTGGAGAAGGAGCGGAGTCTGTCATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB I3B0Q4

Antitoxin

Source ID Structure
AlphaFold DB A0A1D7UPI1

References