Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) yeeUV (cbtA-cbeA)/CbtA-CbeA
Location 1801487..1802318 Replicon chromosome
Accession NZ_CP016018
Organism Escherichia coli strain ER1821R

Toxin (Protein)


Gene name yeeV Uniprot ID S1P968
Locus tag A9X67_RS08765 Protein ID WP_000854814.1
Coordinates 1801487..1801861 (-) Length 125 a.a.

Antitoxin (Protein)


Gene name yeeU Uniprot ID P76364
Locus tag A9X67_RS08770 Protein ID WP_001285584.1
Coordinates 1801950..1802318 (-) Length 123 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
A9X67_RS08730 1796883..1798049 + 1167 WP_000830156.1 serine-type D-Ala-D-Ala carboxypeptidase DacD -
A9X67_RS08735 1798168..1798641 + 474 WP_001105415.1 DNA gyrase inhibitor SbmC -
A9X67_RS08740 1798839..1799897 + 1059 WP_001200891.1 FUSC family protein -
A9X67_RS08745 1800069..1800398 + 330 WP_000450409.1 DUF496 family protein -
A9X67_RS08750 1800499..1800681 - 183 WP_001016348.1 hypothetical protein -
A9X67_RS23340 1800753..1800881 + 129 Protein_1671 transposase domain-containing protein -
A9X67_RS25245 1801170..1801283 - 114 WP_001161660.1 DUF957 domain-containing protein -
A9X67_RS08760 1801296..1801490 - 195 WP_000988600.1 hypothetical protein -
A9X67_RS08765 1801487..1801861 - 375 WP_000854814.1 type IV toxin-antitoxin system toxin CbtA Toxin
A9X67_RS08770 1801950..1802318 - 369 WP_001285584.1 type IV toxin-antitoxin system toxin CbtA Antitoxin
A9X67_RS08775 1802392..1802613 - 222 WP_000692323.1 DUF987 domain-containing protein -
A9X67_RS24750 1802676..1803122 - 447 WP_000187523.1 RadC family protein -
A9X67_RS08785 1803119..1804651 - 1533 WP_001350525.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

CbtA toxin of type IV toxin-antitoxin system

(1-112)

Antitoxin

Antitoxin CbeA

(18-117)


Sequences

Toxin        


Download         Length: 125 a.a.        Molecular weight: 13898.94 Da        Isoelectric Point: 7.8522

>T64130 WP_000854814.1 NZ_CP016018:c1801861-1801487 [Escherichia coli]
MKTLPVLPGQAASSRPSPVEIWQILLSRLLDQHYGLTLNDTPFADERVIEQHIEAGISLCDAVNFLVEKYALVRTDQPGF
SACTRSQLINSIDILRARRATGLMTRDNYRTVNNITLGKYPEAK

Download         Length: 375 bp

>T64130 NZ_CP016018:c1801861-1801487 [Escherichia coli]
ATGAAAACATTACCTGTATTACCCGGGCAGGCGGCCAGTTCTCGCCCGTCTCCTGTTGAAATCTGGCAGATACTGCTGTC
CCGACTGCTGGACCAGCACTATGGCCTCACACTGAATGACACACCTTTTGCCGATGAACGTGTGATTGAGCAGCATATTG
AGGCAGGCATTTCACTGTGTGATGCGGTGAACTTTCTCGTGGAAAAATACGCGCTGGTGCGTACCGACCAGCCGGGATTC
AGCGCCTGTACCCGCTCTCAGTTAATAAACAGCATCGATATCCTCCGGGCTCGCAGGGCGACCGGCCTGATGACCCGCGA
CAATTACAGAACGGTAAATAACATTACCCTGGGTAAGTATCCGGAGGCGAAATGA

Antitoxin


Download         Length: 123 a.a.        Molecular weight: 13651.52 Da        Isoelectric Point: 5.9541

>AT64130 WP_001285584.1 NZ_CP016018:c1802318-1801950 [Escherichia coli]
VSDTLPGTTLPDDNHDRPWWGLPCTVTPCFGARLVQEGNRLHYLADRAGIRGLFSDADAYHLDQAFPLLMKQLELMLTSG
ELNPRHQHTVTLYAKGLTCKADTLSSCDYVYLAVYPTPEMKN

Download         Length: 369 bp

>AT64130 NZ_CP016018:c1802318-1801950 [Escherichia coli]
GTGTCAGACACACTCCCCGGGACAACACTTCCCGACGACAATCACGACCGCCCCTGGTGGGGGCTGCCCTGCACCGTGAC
GCCCTGTTTCGGGGCACGTCTGGTGCAGGAGGGTAACCGGTTGCATTACCTTGCCGACCGCGCCGGTATCAGAGGCCTGT
TCAGCGATGCAGATGCGTACCACCTGGACCAGGCCTTTCCGCTGCTGATGAAACAACTGGAACTCATGCTCACCAGCGGT
GAACTGAATCCCCGCCATCAGCATACCGTCACGCTGTATGCAAAAGGGCTGACCTGCAAAGCCGATACCCTCAGCAGTTG
TGATTACGTTTATCTGGCTGTTTATCCGACGCCCGAAATGAAAAATTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A829FY50

Antitoxin

Source ID Structure
PDB 2H28
AlphaFold DB A0A1M2E8G6

References