Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | hicAB/HicA-HicB |
| Location | 1659855..1660540 | Replicon | chromosome |
| Accession | NZ_CP016017 | ||
| Organism | Neisseria gonorrhoeae strain 34769 | ||
Toxin (Protein)
| Gene name | hicA | Uniprot ID | Q5F6D1 |
| Locus tag | A9Y61_RS08935 | Protein ID | WP_003689143.1 |
| Coordinates | 1660358..1660540 (-) | Length | 61 a.a. |
Antitoxin (Protein)
| Gene name | hicB | Uniprot ID | Q5F6D2 |
| Locus tag | A9Y61_RS08930 | Protein ID | WP_003691454.1 |
| Coordinates | 1659855..1660256 (-) | Length | 134 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| A9Y61_RS08880 | 1655116..1655607 | - | 492 | WP_064668851.1 | siphovirus Gp157 family protein | - |
| A9Y61_RS08885 | 1655604..1655786 | - | 183 | WP_003691535.1 | hypothetical protein | - |
| A9Y61_RS08890 | 1655926..1656612 | - | 687 | WP_042758540.1 | hypothetical protein | - |
| A9Y61_RS08895 | 1656681..1656842 | - | 162 | WP_003693867.1 | hypothetical protein | - |
| A9Y61_RS08900 | 1656839..1657114 | - | 276 | WP_010359972.1 | hypothetical protein | - |
| A9Y61_RS08905 | 1657267..1657599 | - | 333 | WP_064668877.1 | hypothetical protein | - |
| A9Y61_RS08910 | 1657739..1658068 | - | 330 | WP_064668852.1 | hypothetical protein | - |
| A9Y61_RS08915 | 1658065..1658541 | - | 477 | WP_047926956.1 | hypothetical protein | - |
| A9Y61_RS08920 | 1658574..1658774 | - | 201 | WP_064668853.1 | hypothetical protein | - |
| A9Y61_RS08925 | 1658974..1659756 | + | 783 | WP_003689146.1 | hypothetical protein | - |
| A9Y61_RS08930 | 1659855..1660256 | - | 402 | WP_003691454.1 | type II toxin-antitoxin system HicB family antitoxin | Antitoxin |
| A9Y61_RS08935 | 1660358..1660540 | - | 183 | WP_003689143.1 | type II toxin-antitoxin system HicA family toxin | Toxin |
| A9Y61_RS08940 | 1660710..1661528 | - | 819 | WP_012503752.1 | DUF3037 domain-containing protein | - |
| A9Y61_RS08945 | 1661525..1662223 | - | 699 | WP_003689139.1 | hypothetical protein | - |
| A9Y61_RS08950 | 1662462..1663160 | - | 699 | WP_002212401.1 | helix-turn-helix domain-containing protein | - |
| A9Y61_RS08955 | 1663200..1663886 | - | 687 | WP_050164382.1 | helix-turn-helix transcriptional regulator | - |
| A9Y61_RS08960 | 1664051..1664236 | + | 186 | WP_048654326.1 | helix-turn-helix domain-containing protein | - |
| A9Y61_RS14530 | 1664238..1664438 | + | 201 | WP_012503750.1 | hypothetical protein | - |
| A9Y61_RS08970 | 1664635..1665525 | + | 891 | WP_064668854.1 | replication protein | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|---|---|---|---|---|---|---|
| - | inside | Prophage | - | - | 1651031..1678683 | 27652 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 61 a.a. Molecular weight: 6687.77 Da Isoelectric Point: 10.7235
>T64121 WP_003689143.1 NZ_CP016017:c1660540-1660358 [Neisseria gonorrhoeae]
MNSLDVIALLKQDGWYKVAQSGSHSQYKHPTKKGRVTVPHPKKDLPTGTVKNIYKQAGLK
MNSLDVIALLKQDGWYKVAQSGSHSQYKHPTKKGRVTVPHPKKDLPTGTVKNIYKQAGLK
Download Length: 183 bp
>T64121 NZ_CP016017:c1660540-1660358 [Neisseria gonorrhoeae]
TTGAATAGCCTAGACGTTATTGCCCTACTCAAACAAGACGGTTGGTATAAAGTTGCACAATCCGGGAGCCATTCGCAATA
TAAGCACCCAACAAAAAAAGGCCGTGTAACCGTGCCGCACCCGAAAAAAGACTTGCCGACAGGTACTGTAAAAAATATCT
ATAAGCAAGCCGGTTTGAAGTAA
TTGAATAGCCTAGACGTTATTGCCCTACTCAAACAAGACGGTTGGTATAAAGTTGCACAATCCGGGAGCCATTCGCAATA
TAAGCACCCAACAAAAAAAGGCCGTGTAACCGTGCCGCACCCGAAAAAAGACTTGCCGACAGGTACTGTAAAAAATATCT
ATAAGCAAGCCGGTTTGAAGTAA
Antitoxin
Download Length: 134 a.a. Molecular weight: 14634.43 Da Isoelectric Point: 4.5457
>AT64121 WP_003691454.1 NZ_CP016017:c1660256-1659855 [Neisseria gonorrhoeae]
MFIPAALHKDEHSAYGVTIPDLPGCFSCGDTVEEAVANARSAAYMHIDGMIEDGGFKNLAVSSIADLSQEPDYHGATWVM
IEIDPAKISRQQIRFNVSWPQYLLDRVDEYTSANHETRSGFLAKAALLTMNQA
MFIPAALHKDEHSAYGVTIPDLPGCFSCGDTVEEAVANARSAAYMHIDGMIEDGGFKNLAVSSIADLSQEPDYHGATWVM
IEIDPAKISRQQIRFNVSWPQYLLDRVDEYTSANHETRSGFLAKAALLTMNQA
Download Length: 402 bp
>AT64121 NZ_CP016017:c1660256-1659855 [Neisseria gonorrhoeae]
ATGTTTATCCCTGCCGCCCTGCACAAAGACGAACATTCGGCATATGGCGTAACCATCCCCGACCTTCCCGGCTGTTTCTC
TTGCGGCGACACCGTTGAAGAAGCCGTCGCCAACGCCCGTTCTGCCGCCTATATGCATATTGACGGTATGATTGAGGACG
GAGGGTTCAAAAACCTTGCCGTAAGCAGCATTGCCGATTTGAGCCAAGAACCTGATTATCATGGGGCAACATGGGTAATG
ATTGAAATCGACCCTGCAAAAATCAGTCGGCAGCAAATCCGATTCAACGTCAGCTGGCCGCAATACCTTCTTGATAGAGT
GGATGAATATACATCCGCAAATCATGAAACCCGTAGCGGTTTTTTAGCCAAAGCCGCCCTGCTCACCATGAATCAGGCAT
AG
ATGTTTATCCCTGCCGCCCTGCACAAAGACGAACATTCGGCATATGGCGTAACCATCCCCGACCTTCCCGGCTGTTTCTC
TTGCGGCGACACCGTTGAAGAAGCCGTCGCCAACGCCCGTTCTGCCGCCTATATGCATATTGACGGTATGATTGAGGACG
GAGGGTTCAAAAACCTTGCCGTAAGCAGCATTGCCGATTTGAGCCAAGAACCTGATTATCATGGGGCAACATGGGTAATG
ATTGAAATCGACCCTGCAAAAATCAGTCGGCAGCAAATCCGATTCAACGTCAGCTGGCCGCAATACCTTCTTGATAGAGT
GGATGAATATACATCCGCAAATCATGAAACCCGTAGCGGTTTTTTAGCCAAAGCCGCCCTGCTCACCATGAATCAGGCAT
AG
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|