Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | hicAB/HicA-HicB |
| Location | 1639350..1640035 | Replicon | chromosome |
| Accession | NZ_CP016015 | ||
| Organism | Neisseria gonorrhoeae strain 32867 | ||
Toxin (Protein)
| Gene name | hicA | Uniprot ID | Q5F6D1 |
| Locus tag | ASO12_RS08820 | Protein ID | WP_003689143.1 |
| Coordinates | 1639853..1640035 (-) | Length | 61 a.a. |
Antitoxin (Protein)
| Gene name | hicB | Uniprot ID | Q5F6D2 |
| Locus tag | ASO12_RS08815 | Protein ID | WP_003691454.1 |
| Coordinates | 1639350..1639751 (-) | Length | 134 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| ASO12_RS08760 | 1634391..1634606 | - | 216 | WP_003691538.1 | hypothetical protein | - |
| ASO12_RS08765 | 1634658..1635149 | - | 492 | WP_003691537.1 | siphovirus Gp157 family protein | - |
| ASO12_RS08770 | 1635146..1635328 | - | 183 | WP_003691535.1 | hypothetical protein | - |
| ASO12_RS08775 | 1635468..1636154 | - | 687 | WP_042758540.1 | hypothetical protein | - |
| ASO12_RS08780 | 1636223..1636384 | - | 162 | WP_003691530.1 | hypothetical protein | - |
| ASO12_RS08785 | 1636381..1636659 | - | 279 | WP_047921579.1 | hypothetical protein | - |
| ASO12_RS08790 | 1636813..1637145 | - | 333 | WP_003695500.1 | hypothetical protein | - |
| ASO12_RS08795 | 1637286..1637573 | - | 288 | WP_050171272.1 | hypothetical protein | - |
| ASO12_RS08800 | 1637570..1638046 | - | 477 | WP_002255718.1 | hypothetical protein | - |
| ASO12_RS08805 | 1638079..1638279 | - | 201 | WP_047919800.1 | hypothetical protein | - |
| ASO12_RS08810 | 1638469..1639251 | + | 783 | WP_003689146.1 | hypothetical protein | - |
| ASO12_RS08815 | 1639350..1639751 | - | 402 | WP_003691454.1 | type II toxin-antitoxin system HicB family antitoxin | Antitoxin |
| ASO12_RS08820 | 1639853..1640035 | - | 183 | WP_003689143.1 | type II toxin-antitoxin system HicA family toxin | Toxin |
| ASO12_RS08825 | 1640205..1641023 | - | 819 | WP_025455900.1 | DUF3037 domain-containing protein | - |
| ASO12_RS08830 | 1641020..1641718 | - | 699 | WP_003689139.1 | hypothetical protein | - |
| ASO12_RS08835 | 1641957..1642667 | - | 711 | WP_025455899.1 | helix-turn-helix transcriptional regulator | - |
| ASO12_RS08840 | 1642783..1642971 | + | 189 | WP_003689136.1 | helix-turn-helix domain-containing protein | - |
| ASO12_RS14615 | 1643051..1643311 | + | 261 | WP_165865284.1 | hypothetical protein | - |
| ASO12_RS08850 | 1643544..1643771 | + | 228 | WP_003691442.1 | helix-turn-helix domain-containing protein | - |
| ASO12_RS08855 | 1643768..1644784 | + | 1017 | WP_064662136.1 | helix-turn-helix domain-containing protein | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|---|---|---|---|---|---|---|
| - | inside | Integrative and Conjugative Element | - | - | 1624163..1657673 | 33510 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 61 a.a. Molecular weight: 6687.77 Da Isoelectric Point: 10.7235
>T64118 WP_003689143.1 NZ_CP016015:c1640035-1639853 [Neisseria gonorrhoeae]
MNSLDVIALLKQDGWYKVAQSGSHSQYKHPTKKGRVTVPHPKKDLPTGTVKNIYKQAGLK
MNSLDVIALLKQDGWYKVAQSGSHSQYKHPTKKGRVTVPHPKKDLPTGTVKNIYKQAGLK
Download Length: 183 bp
>T64118 NZ_CP016015:c1640035-1639853 [Neisseria gonorrhoeae]
TTGAATAGCCTAGACGTTATTGCCCTACTCAAACAAGACGGTTGGTATAAAGTTGCACAATCCGGGAGCCATTCGCAATA
TAAGCACCCAACAAAAAAAGGCCGTGTAACCGTGCCGCACCCGAAAAAAGACTTGCCGACAGGTACTGTAAAAAATATCT
ATAAGCAAGCCGGTTTGAAGTAA
TTGAATAGCCTAGACGTTATTGCCCTACTCAAACAAGACGGTTGGTATAAAGTTGCACAATCCGGGAGCCATTCGCAATA
TAAGCACCCAACAAAAAAAGGCCGTGTAACCGTGCCGCACCCGAAAAAAGACTTGCCGACAGGTACTGTAAAAAATATCT
ATAAGCAAGCCGGTTTGAAGTAA
Antitoxin
Download Length: 134 a.a. Molecular weight: 14634.43 Da Isoelectric Point: 4.5457
>AT64118 WP_003691454.1 NZ_CP016015:c1639751-1639350 [Neisseria gonorrhoeae]
MFIPAALHKDEHSAYGVTIPDLPGCFSCGDTVEEAVANARSAAYMHIDGMIEDGGFKNLAVSSIADLSQEPDYHGATWVM
IEIDPAKISRQQIRFNVSWPQYLLDRVDEYTSANHETRSGFLAKAALLTMNQA
MFIPAALHKDEHSAYGVTIPDLPGCFSCGDTVEEAVANARSAAYMHIDGMIEDGGFKNLAVSSIADLSQEPDYHGATWVM
IEIDPAKISRQQIRFNVSWPQYLLDRVDEYTSANHETRSGFLAKAALLTMNQA
Download Length: 402 bp
>AT64118 NZ_CP016015:c1639751-1639350 [Neisseria gonorrhoeae]
ATGTTTATCCCTGCCGCCCTGCACAAAGACGAACATTCGGCATATGGCGTAACCATCCCCGACCTTCCCGGCTGTTTCTC
TTGCGGCGACACCGTTGAAGAAGCCGTCGCCAACGCCCGTTCTGCCGCCTATATGCATATTGACGGTATGATTGAGGACG
GAGGGTTCAAAAACCTTGCCGTAAGCAGCATTGCCGATTTGAGCCAAGAACCTGATTATCATGGGGCAACATGGGTAATG
ATTGAAATCGACCCTGCAAAAATCAGTCGGCAGCAAATCCGATTCAACGTCAGCTGGCCGCAATACCTTCTTGATAGAGT
GGATGAATATACATCCGCAAATCATGAAACCCGTAGCGGTTTTTTAGCCAAAGCCGCCCTGCTTACCATGAATCAGGCAT
AG
ATGTTTATCCCTGCCGCCCTGCACAAAGACGAACATTCGGCATATGGCGTAACCATCCCCGACCTTCCCGGCTGTTTCTC
TTGCGGCGACACCGTTGAAGAAGCCGTCGCCAACGCCCGTTCTGCCGCCTATATGCATATTGACGGTATGATTGAGGACG
GAGGGTTCAAAAACCTTGCCGTAAGCAGCATTGCCGATTTGAGCCAAGAACCTGATTATCATGGGGCAACATGGGTAATG
ATTGAAATCGACCCTGCAAAAATCAGTCGGCAGCAAATCCGATTCAACGTCAGCTGGCCGCAATACCTTCTTGATAGAGT
GGATGAATATACATCCGCAAATCATGAAACCCGTAGCGGTTTTTTAGCCAAAGCCGCCCTGCTTACCATGAATCAGGCAT
AG
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|