Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/VapC-StbC
Location 654395..655050 Replicon chromosome
Accession NZ_CP016015
Organism Neisseria gonorrhoeae strain 32867

Toxin (Protein)


Gene name vapC Uniprot ID Q5F882
Locus tag ASO12_RS03650 Protein ID WP_003691083.1
Coordinates 654631..655050 (+) Length 140 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID Q5F881
Locus tag ASO12_RS03645 Protein ID WP_003688410.1
Coordinates 654395..654631 (+) Length 79 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
ASO12_RS03610 649529..649816 + 288 WP_003688407.1 hypothetical protein -
ASO12_RS03615 649888..651054 + 1167 WP_003688408.1 ADP-forming succinate--CoA ligase subunit beta -
ASO12_RS03620 651065..651955 + 891 WP_002244992.1 succinate--CoA ligase subunit alpha -
ASO12_RS03625 652338..652724 - 387 Protein_669 IS110 family transposase -
ASO12_RS03630 652936..653364 + 429 WP_003701165.1 helix-turn-helix domain-containing protein -
ASO12_RS03635 653369..653947 + 579 WP_003688041.1 IS3 family transposase -
ASO12_RS13960 653992..654189 + 198 WP_033910354.1 IS3 family transposase -
ASO12_RS03645 654395..654631 + 237 WP_003688410.1 type II toxin-antitoxin system antitoxin FitA Antitoxin
ASO12_RS03650 654631..655050 + 420 WP_003691083.1 type II toxin-antitoxin system toxin FitB Toxin
ASO12_RS03655 655199..656653 - 1455 WP_003688412.1 iron-sulfur cluster-binding protein -
ASO12_RS03660 656650..657351 - 702 WP_003688414.1 lactate utilization protein C -
ASO12_RS03665 657348..658127 - 780 WP_003688416.1 (Fe-S)-binding protein -
ASO12_RS03670 658275..659816 + 1542 WP_003688418.1 multidrug efflux MFS transporter -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(2-124)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 140 a.a.        Molecular weight: 15306.65 Da        Isoelectric Point: 6.0798

>T64117 WP_003691083.1 NZ_CP016015:654631-655050 [Neisseria gonorrhoeae]
MILLDTNVISEPLRPQPNERVVAWLDSLILEDVYLSAITVAELRLGVALLLNGKKKNVLHERLEQSILPLFAGRILPFDE
PVAAIYAQIRSYAKTHGKEIAAADGYIAATAKQHSLTVATRDTGSFFAADVAVFNPWHD

Download         Length: 420 bp

>T64117 NZ_CP016015:654631-655050 [Neisseria gonorrhoeae]
ATGATTTTGCTGGACACGAATGTGATTTCCGAACCTTTGCGCCCACAACCCAATGAACGTGTGGTGGCATGGTTGGATAG
TTTGATATTGGAAGATGTGTATTTGTCTGCCATTACTGTTGCAGAATTGCGTTTGGGTGTGGCGTTGTTGCTCAATGGCA
AGAAAAAGAATGTGCTGCACGAACGTTTGGAACAATCCATTTTGCCTTTATTTGCGGGGCGGATTCTGCCTTTTGATGAA
CCGGTTGCCGCAATCTATGCGCAAATTCGTTCCTATGCCAAAACACATGGCAAAGAGATTGCTGCCGCAGACGGCTATAT
TGCCGCCACTGCAAAACAGCACAGTTTGACAGTTGCTACGCGTGATACCGGCTCATTTTTTGCGGCCGATGTCGCGGTGT
TCAATCCGTGGCACGATTAA

Antitoxin


Download         Length: 79 a.a.        Molecular weight: 8433.57 Da        Isoelectric Point: 7.0129

>AT64117 WP_003688410.1 NZ_CP016015:654395-654631 [Neisseria gonorrhoeae]
MASVVIRNLSEATHNAIKFRARAAGRSTEAEIRLILDNIAKAQQTVRLGSMLASIGQEIGGVELEDVRGRNTDNEVSL

Download         Length: 237 bp

>AT64117 NZ_CP016015:654395-654631 [Neisseria gonorrhoeae]
ATGGCTTCTGTTGTGATTAGAAATTTATCCGAGGCCACGCACAACGCAATCAAATTCCGTGCGCGAGCCGCAGGGCGCAG
TACCGAAGCAGAAATCCGCTTAATTTTGGATAACATCGCCAAAGCACAACAAACTGTACGTTTGGGGTCAATGTTGGCAT
CAATAGGGCAGGAAATCGGAGGTGTTGAGCTGGAAGACGTACGCGGTCGTAATACTGATAACGAGGTTTCTTTGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 2H1C
PDB 2BSQ
PDB 2H1O

Antitoxin

Source ID Structure
PDB 2H1C
PDB 2BSQ
PDB 2H1O
AlphaFold DB Q5F881

References