Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) yeeUV (cbtA-cbeA)/CbtA-CbeA
Location 4486804..4487639 Replicon chromosome
Accession NZ_CP015995
Organism Escherichia coli strain S51

Toxin (Protein)


Gene name yeeV Uniprot ID A0A3K1A7W0
Locus tag A9K64_RS22610 Protein ID WP_021547705.1
Coordinates 4487262..4487639 (+) Length 126 a.a.

Antitoxin (Protein)


Gene name yeeU Uniprot ID A0A7W3AJG7
Locus tag A9K64_RS22605 Protein ID WP_001389198.1
Coordinates 4486804..4487172 (+) Length 123 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
A9K64_RS22570 4482716..4483396 + 681 WP_001282912.1 WYL domain-containing protein -
A9K64_RS22575 4483547..4484224 + 678 WP_001097567.1 hypothetical protein -
A9K64_RS22580 4484230..4484463 + 234 WP_001278282.1 DUF905 family protein -
A9K64_RS22585 4484553..4485371 + 819 WP_021547707.1 DUF945 domain-containing protein -
A9K64_RS22590 4485463..4485948 + 486 WP_021547706.1 antirestriction protein -
A9K64_RS22595 4485964..4486440 + 477 WP_001186727.1 RadC family protein -
A9K64_RS22600 4486503..4486724 + 222 WP_000692345.1 DUF987 domain-containing protein -
A9K64_RS22605 4486804..4487172 + 369 WP_001389198.1 type IV toxin-antitoxin system YeeU family antitoxin Antitoxin
A9K64_RS22610 4487262..4487639 + 378 WP_021547705.1 TA system toxin CbtA family protein Toxin
A9K64_RS22615 4487636..4488124 + 489 WP_000761678.1 hypothetical protein -
A9K64_RS22620 4488136..4488333 + 198 WP_000839239.1 DUF957 domain-containing protein -
A9K64_RS22625 4488418..4489284 + 867 WP_021547704.1 DUF4942 domain-containing protein -
A9K64_RS22630 4489356..4489619 + 264 WP_001143297.1 type II toxin-antitoxin system ParD family antitoxin -
A9K64_RS22635 4489616..4489942 + 327 WP_000779483.1 type II toxin-antitoxin system RelE/ParE family toxin -
A9K64_RS22645 4490825..4492363 + 1539 WP_001187177.1 lysine decarboxylation/transport transcriptional activator CadC -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Genomic island - - 4407236..4500176 92940


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

CbtA toxin of type IV toxin-antitoxin system

(1-112)

Antitoxin

Antitoxin CbeA

(18-117)


Sequences

Toxin        


Download         Length: 126 a.a.        Molecular weight: 13992.02 Da        Isoelectric Point: 7.7293

>T64079 WP_021547705.1 NZ_CP015995:4487262-4487639 [Escherichia coli]
MKTLPDTHVREASRCPSPVTIWQILLSRLLDQHYGLTLNDTPFADERVIEQHIEAGISLCDAVNFLVEKYALVRTDQPGF
SACSCSQLINSIDILRARRATGLMARDNYRTVNNITLGKHPGAKQ

Download         Length: 378 bp

>T64079 NZ_CP015995:4487262-4487639 [Escherichia coli]
ATGAAAACATTACCCGACACGCATGTACGGGAGGCATCGCGCTGCCCGTCTCCCGTCACCATCTGGCAGATACTGCTGTC
CCGACTGCTGGACCAGCATTACGGCCTCACACTGAATGACACACCGTTTGCCGATGAACGTGTGATTGAGCAGCATATTG
AGGCCGGCATTTCACTGTGCGATGCAGTGAACTTTCTCGTTGAAAAATACGCCCTGGTACGTACCGACCAGCCGGGATTC
AGCGCCTGTAGCTGCTCTCAGTTAATCAACAGTATCGATATCCTCCGGGCACGCCGGGCAACCGGCCTGATGGCCCGCGA
CAATTACAGAACGGTAAATAACATTACCCTGGGTAAACATCCGGGGGCGAAACAATGA

Antitoxin


Download         Length: 123 a.a.        Molecular weight: 13610.39 Da        Isoelectric Point: 6.3159

>AT64079 WP_001389198.1 NZ_CP015995:4486804-4487172 [Escherichia coli]
VSDTLPGTTHPDDNNDRPWWGLPCTVTPCFGARLVQEGNRLHYLADRAGIRGRFSDADAYHLDQAFPLLMKQLELMLTSG
ELNPRHQHTVTLYAKGLTCEADTLGSCGYVYMAVYPTPETKK

Download         Length: 369 bp

>AT64079 NZ_CP015995:4486804-4487172 [Escherichia coli]
GTGTCAGACACACTCCCCGGGACAACGCATCCCGACGATAACAACGACCGCCCCTGGTGGGGGCTACCCTGCACCGTGAC
GCCCTGTTTTGGGGCACGTCTGGTGCAGGAGGGTAACCGGTTGCATTACCTTGCCGACCGCGCCGGTATCAGAGGCCGGT
TCAGCGACGCGGATGCGTACCATCTGGACCAGGCCTTTCCGCTGCTGATGAAACAACTGGAGCTCATGCTCACCAGCGGT
GAACTGAATCCCCGCCATCAGCATACCGTGACACTGTATGCAAAAGGGCTGACCTGCGAAGCCGACACCCTCGGCAGTTG
TGGCTACGTTTATATGGCTGTTTATCCGACGCCCGAAACGAAAAAGTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A3K1A7W0

Antitoxin

Source ID Structure
AlphaFold DB A0A7W3AJG7

References