Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | relBE/ParE-RelB |
| Location | 2412647..2413173 | Replicon | chromosome |
| Accession | NZ_CP015995 | ||
| Organism | Escherichia coli strain S51 | ||
Toxin (Protein)
| Gene name | relE | Uniprot ID | S1EXL1 |
| Locus tag | A9K64_RS12130 | Protein ID | WP_000323025.1 |
| Coordinates | 2412647..2412934 (-) | Length | 96 a.a. |
Antitoxin (Protein)
| Gene name | relB | Uniprot ID | S1F6D3 |
| Locus tag | A9K64_RS12135 | Protein ID | WP_000534858.1 |
| Coordinates | 2412934..2413173 (-) | Length | 80 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| A9K64_RS12090 | 2407674..2407889 | - | 216 | WP_000839590.1 | phage lysis protein EssD | - |
| A9K64_RS29660 | 2408108..2408278 | + | 171 | WP_001405948.1 | putative zinc-binding protein YnfU | - |
| A9K64_RS12095 | 2408642..2408857 | - | 216 | WP_000066485.1 | cold shock-like protein CspB | - |
| A9K64_RS12100 | 2409156..2409368 | + | 213 | WP_024172454.1 | cold shock-like protein CspF | - |
| A9K64_RS29050 | 2409423..2409512 | + | 90 | WP_122985911.1 | hypothetical protein | - |
| A9K64_RS12105 | 2409790..2410542 | - | 753 | WP_001047135.1 | antitermination protein | - |
| A9K64_RS12110 | 2410556..2411605 | - | 1050 | WP_001439074.1 | DUF968 domain-containing protein | - |
| A9K64_RS12115 | 2411607..2411885 | - | 279 | WP_012304870.1 | hypothetical protein | - |
| A9K64_RS12120 | 2411952..2412203 | - | 252 | WP_000980994.1 | hypothetical protein | - |
| A9K64_RS12125 | 2412420..2412575 | - | 156 | WP_000813254.1 | type I toxin-antitoxin system toxin HokD | - |
| A9K64_RS12130 | 2412647..2412934 | - | 288 | WP_000323025.1 | type II toxin-antitoxin system mRNA interferase RelE | Toxin |
| A9K64_RS12135 | 2412934..2413173 | - | 240 | WP_000534858.1 | type II toxin-antitoxin system antitoxin RelB | Antitoxin |
| A9K64_RS26925 | 2413198..2413503 | + | 306 | WP_001326990.1 | hypothetical protein | - |
| A9K64_RS12140 | 2413706..2414038 | + | 333 | WP_001301033.1 | protein FlxA | - |
| A9K64_RS12145 | 2414475..2415815 | - | 1341 | WP_000589013.1 | ISNCY family transposase | - |
| A9K64_RS12160 | 2416584..2416870 | - | 287 | Protein_2327 | hypothetical protein | - |
| A9K64_RS29665 | 2417036..2417218 | - | 183 | Protein_2328 | hypothetical protein | - |
| A9K64_RS12165 | 2417481..2417837 | - | 357 | WP_001315552.1 | class I SAM-dependent methyltransferase | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|---|---|---|---|---|---|---|
| - | inside | Prophage | - | - | 2383658..2438068 | 54410 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 96 a.a. Molecular weight: 11225.22 Da Isoelectric Point: 10.1967
>T64064 WP_000323025.1 NZ_CP015995:c2412934-2412647 [Escherichia coli]
MAYFLDFDERALKEWRKLGSTVREQLKKKLVEVLESPRIEANKLRGMPDCYKIKLRSSGYRLVYQVIDEKVVVFVISVGK
RERSEVYSEAVKRIL
MAYFLDFDERALKEWRKLGSTVREQLKKKLVEVLESPRIEANKLRGMPDCYKIKLRSSGYRLVYQVIDEKVVVFVISVGK
RERSEVYSEAVKRIL
Download Length: 288 bp
>T64064 NZ_CP015995:c2412934-2412647 [Escherichia coli]
ATGGCGTATTTTCTGGATTTTGACGAGCGGGCACTAAAGGAATGGCGAAAGCTGGGCTCGACGGTACGTGAACAGTTGAA
AAAGAAGCTGGTTGAAGTACTTGAGTCACCCCGGATTGAAGCAAACAAGCTCCGTGGTATGCCTGATTGTTACAAGATTA
AGCTCCGGTCTTCAGGCTATCGCCTTGTATACCAGGTTATAGACGAGAAAGTTGTCGTTTTCGTGATTTCTGTTGGGAAA
AGAGAACGCTCGGAAGTATATAGCGAGGCGGTCAAACGCATTCTCTGA
ATGGCGTATTTTCTGGATTTTGACGAGCGGGCACTAAAGGAATGGCGAAAGCTGGGCTCGACGGTACGTGAACAGTTGAA
AAAGAAGCTGGTTGAAGTACTTGAGTCACCCCGGATTGAAGCAAACAAGCTCCGTGGTATGCCTGATTGTTACAAGATTA
AGCTCCGGTCTTCAGGCTATCGCCTTGTATACCAGGTTATAGACGAGAAAGTTGTCGTTTTCGTGATTTCTGTTGGGAAA
AGAGAACGCTCGGAAGTATATAGCGAGGCGGTCAAACGCATTCTCTGA
Antitoxin
Download Length: 80 a.a. Molecular weight: 9071.48 Da Isoelectric Point: 4.5230
>AT64064 WP_000534858.1 NZ_CP015995:c2413173-2412934 [Escherichia coli]
MGSINLRIDDELKARSYAALEKMGVTPSEALRLMLEYIADNERLPFKQTLLSDEDAELVEIVKERLRNPKPVRVTLDEL
MGSINLRIDDELKARSYAALEKMGVTPSEALRLMLEYIADNERLPFKQTLLSDEDAELVEIVKERLRNPKPVRVTLDEL
Download Length: 240 bp
>AT64064 NZ_CP015995:c2413173-2412934 [Escherichia coli]
ATGGGTAGCATTAACCTGCGTATTGACGATGAACTTAAAGCGCGTTCTTACGCCGCGCTTGAAAAAATGGGTGTAACTCC
TTCTGAAGCGCTTCGTCTCATGCTCGAGTATATCGCTGACAATGAACGCTTGCCGTTCAAACAGACACTCCTGAGTGATG
AAGATGCTGAACTTGTGGAGATAGTGAAAGAACGGCTTCGTAATCCTAAGCCAGTACGTGTGACGCTGGATGAACTCTGA
ATGGGTAGCATTAACCTGCGTATTGACGATGAACTTAAAGCGCGTTCTTACGCCGCGCTTGAAAAAATGGGTGTAACTCC
TTCTGAAGCGCTTCGTCTCATGCTCGAGTATATCGCTGACAATGAACGCTTGCCGTTCAAACAGACACTCCTGAGTGATG
AAGATGCTGAACTTGTGGAGATAGTGAAAGAACGGCTTCGTAATCCTAAGCCAGTACGTGTGACGCTGGATGAACTCTGA
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|