Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) /Acetyltransf_4(toxin)
Location 1438197..1439611 Replicon chromosome
Accession NZ_CP015992
Organism Pseudomonas sp. TCU-HL1

Toxin (Protein)


Gene name - Uniprot ID A0A1B3E2U6
Locus tag THL1_RS06605 Protein ID WP_069082514.1
Coordinates 1438197..1438766 (+) Length 190 a.a.

Antitoxin (Protein)


Gene name - Uniprot ID -
Locus tag THL1_RS06610 Protein ID WP_193791643.1
Coordinates 1438772..1439611 (+) Length 280 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
THL1_RS06595 1433837..1434256 + 420 WP_069086431.1 hypothetical protein -
THL1_RS06600 1434465..1437944 - 3480 WP_069082513.1 hybrid sensor histidine kinase/response regulator -
THL1_RS06605 1438197..1438766 + 570 WP_069082514.1 GNAT family N-acetyltransferase Toxin
THL1_RS06610 1438772..1439611 + 840 WP_193791643.1 AraC family transcriptional regulator Antitoxin
THL1_RS06615 1439648..1440379 + 732 WP_069082516.1 AzlC family ABC transporter permease -
THL1_RS06620 1440361..1440690 + 330 WP_069082517.1 AzlD domain-containing protein -
THL1_RS06625 1440917..1442791 + 1875 WP_069082518.1 MFS transporter -
THL1_RS06630 1443000..1443314 - 315 WP_069082519.1 quaternary ammonium compound efflux SMR transporter SugE -
THL1_RS06635 1443493..1444413 - 921 WP_069082520.1 recombination-associated protein RdgC -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

GNAT domain

(14-146)

Antitoxin

DNA binding HTH domain, AraC-type

(193-270)


Sequences

Toxin        


Download         Length: 190 a.a.        Molecular weight: 21167.27 Da        Isoelectric Point: 8.5207

>T64046 WP_069082514.1 NZ_CP015992:1438197-1438766 [Pseudomonas sp. TCU-HL1]
MFNPQPVTLQRGALRLDPLLEADIPALVTLAEANRDALVYMNGPLRPDWYRQGLAAQREGQAVVFAIRLGDNLMGTTRFA
DFIPSLPAAEIGWTWLAAGEHGTGLNASIKYLMLRHAFEEWQLVRVQLKTAASNLRAQRAIEKLGAQREGLLRNHRRLAG
GRLDDSVLYSITDHDWPEVKQRLEALFSA

Download         Length: 570 bp

>T64046 NZ_CP015992:1438197-1438766 [Pseudomonas sp. TCU-HL1]
ATGTTCAATCCACAACCGGTCACCCTGCAGCGCGGCGCCTTGCGCCTCGACCCGCTGCTGGAGGCCGATATCCCGGCGCT
GGTAACCCTGGCCGAAGCCAACCGCGACGCACTGGTTTACATGAATGGCCCGCTGCGTCCCGACTGGTATCGCCAGGGGC
TGGCGGCCCAACGGGAAGGGCAGGCGGTGGTCTTCGCCATCCGCTTGGGTGACAACCTGATGGGCACCACCCGTTTTGCC
GATTTCATTCCCAGCCTGCCGGCTGCCGAGATCGGCTGGACCTGGCTGGCCGCCGGTGAGCACGGCACGGGCCTGAATGC
CTCGATCAAGTACCTGATGCTGCGCCATGCCTTCGAGGAGTGGCAGCTGGTGCGGGTGCAACTGAAGACCGCCGCCAGCA
ACCTGCGCGCCCAGCGTGCCATCGAGAAGCTCGGCGCCCAGCGCGAAGGCCTGCTGCGCAACCATCGGCGCCTCGCGGGC
GGCCGCCTCGACGACAGCGTGCTCTACAGCATCACTGACCACGACTGGCCAGAAGTGAAACAACGCCTGGAGGCGCTTTT
CAGCGCGTGA

Antitoxin


Download         Length: 280 a.a.        Molecular weight: 31200.43 Da        Isoelectric Point: 8.0596

>AT64046 WP_193791643.1 NZ_CP015992:1438772-1439611 [Pseudomonas sp. TCU-HL1]
MASGETTRFWQARELGGVELLHARYIEQRFAPHVHEGYVFTVIESGAQRFRHRGSDHLAPVGSMVLINPDELHTGSKAHE
QGWRYRGFYPDLERVTEVLEELDIRMNGLPGFADSVIQDAEVVATFLRLHRMLEGSTPALQVQAAWREAILLLFRRHARI
AVPREAGVEPRAVAQAREILSAHLAEPPSLEELAAEVGLSPFHFARTFRRATGMPPHAWLKQQRLDQARALLKAGCAPAS
VAAQLGFSDQSHLTRQFKQAYGVGPGEYRTACARSFNTH

Download         Length: 840 bp

>AT64046 NZ_CP015992:1438772-1439611 [Pseudomonas sp. TCU-HL1]
ATGGCGAGCGGCGAGACTACGCGCTTCTGGCAGGCCCGCGAGCTGGGCGGAGTGGAGCTGCTCCATGCCCGCTACATCGA
GCAGCGTTTCGCTCCCCATGTGCATGAAGGCTATGTGTTCACCGTGATCGAGTCCGGTGCGCAGCGCTTCCGTCACCGTG
GTAGCGACCACCTGGCGCCGGTGGGCAGCATGGTGCTGATCAATCCCGATGAGTTGCACACCGGTTCCAAGGCTCATGAG
CAGGGCTGGCGCTACCGGGGGTTTTACCCGGACCTTGAGCGGGTGACTGAGGTACTGGAGGAACTGGATATCCGGATGAA
CGGCCTGCCGGGGTTCGCCGATAGCGTTATCCAGGACGCCGAGGTAGTGGCTACCTTCCTGCGGTTGCACCGGATGCTGG
AGGGCAGCACCCCCGCGCTTCAAGTCCAGGCGGCCTGGCGCGAGGCGATTCTGCTGCTGTTCCGGCGCCATGCGCGTATC
GCCGTACCTCGTGAAGCCGGGGTCGAACCACGCGCCGTGGCTCAGGCACGGGAAATTCTCTCCGCGCATCTGGCCGAGCC
GCCATCGCTTGAAGAGCTGGCAGCCGAGGTGGGGTTGTCACCCTTCCATTTCGCCCGGACCTTTCGCCGGGCCACCGGCA
TGCCTCCCCATGCCTGGCTCAAGCAGCAACGCCTGGACCAGGCCCGCGCCCTGCTCAAGGCCGGTTGTGCGCCGGCCAGC
GTGGCGGCACAGCTGGGCTTCTCCGACCAGAGCCACCTGACCCGCCAATTCAAGCAGGCCTACGGCGTTGGGCCGGGCGA
ATATCGCACCGCCTGCGCAAGATCGTTCAATACCCACTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A1B3E2U6

Antitoxin

Source ID Structure

References