Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/ParE-RelB
Location 4832459..4832975 Replicon chromosome
Accession NZ_CP015990
Organism Klebsiella pneumoniae strain BR

Toxin (Protein)


Gene name relE Uniprot ID R4YAY3
Locus tag A9J37_RS23540 Protein ID WP_004178374.1
Coordinates 4832459..4832743 (-) Length 95 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID R4Y888
Locus tag A9J37_RS23545 Protein ID WP_002886901.1
Coordinates 4832733..4832975 (-) Length 81 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
A9J37_RS23510 4827943..4828251 - 309 WP_022631369.1 PTS sugar transporter subunit IIB -
A9J37_RS29285 4828336..4828509 + 174 WP_032408826.1 hypothetical protein -
A9J37_RS23520 4828512..4829255 + 744 WP_002886905.1 MurR/RpiR family transcriptional regulator -
A9J37_RS23530 4829612..4831750 + 2139 WP_004186701.1 anaerobic ribonucleoside-triphosphate reductase -
A9J37_RS23535 4831991..4832455 + 465 WP_004178375.1 anaerobic ribonucleoside-triphosphate reductase-activating protein -
A9J37_RS23540 4832459..4832743 - 285 WP_004178374.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
A9J37_RS23545 4832733..4832975 - 243 WP_002886901.1 type II toxin-antitoxin system RelB/DinJ family antitoxin Antitoxin
A9J37_RS23550 4833053..4834963 - 1911 WP_004178373.1 BglG family transcription antiterminator -
A9J37_RS23555 4834986..4836140 - 1155 WP_004178372.1 lactonase family protein -
A9J37_RS23560 4836207..4836947 - 741 WP_002886899.1 KDGP aldolase family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(5-83)

Antitoxin

RelB antitoxin/Antitoxin DinJ

(1-80)


Sequences

Toxin        


Download         Length: 95 a.a.        Molecular weight: 11155.97 Da        Isoelectric Point: 10.3787

>T64041 WP_004178374.1 NZ_CP015990:c4832743-4832459 [Klebsiella pneumoniae]
MTYELEFDPRAWREWQKPGETVKKQFKNKLQQIVQNPRIESTRLSDLPDCYKIKLKASGYRLVYQVRDSVVVVYVIAIGK
REKAAVYHQANKRL

Download         Length: 285 bp

>T64041 NZ_CP015990:c4832743-4832459 [Klebsiella pneumoniae]
ATGACCTATGAACTGGAGTTTGATCCACGAGCCTGGCGCGAATGGCAGAAGCCTGGCGAGACGGTCAAAAAACAGTTCAA
AAATAAGCTCCAGCAGATTGTGCAGAATCCGCGAATTGAGTCGACCAGGCTGAGCGATTTACCGGATTGCTACAAAATCA
AGCTTAAGGCGTCAGGTTATCGGTTGGTGTATCAAGTACGAGATAGTGTGGTGGTGGTTTACGTTATTGCCATTGGCAAA
AGAGAGAAAGCGGCCGTTTATCATCAGGCGAATAAACGGCTCTAA

Antitoxin


Download         Length: 81 a.a.        Molecular weight: 9045.55 Da        Isoelectric Point: 6.3340

>AT64041 WP_002886901.1 NZ_CP015990:c4832975-4832733 [Klebsiella pneumoniae]
MATLNVRLDDKLKKEAYAVLEKLDMTPTEAVRLLFQYIAENGRMPVKSMTISDGEAALLRTVRERLENPRPGVKVSLDDL

Download         Length: 243 bp

>AT64041 NZ_CP015990:c4832975-4832733 [Klebsiella pneumoniae]
ATGGCCACGCTCAATGTTCGACTGGACGATAAACTCAAAAAAGAGGCTTATGCCGTGCTGGAGAAACTCGATATGACACC
AACGGAGGCGGTACGCCTGCTGTTTCAATACATTGCGGAAAATGGCCGCATGCCGGTGAAAAGTATGACCATCAGTGATG
GCGAAGCGGCGTTATTACGCACCGTTCGCGAACGGCTGGAAAACCCACGGCCGGGGGTTAAGGTGAGTCTGGATGACCTA
TGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A6THG1

Antitoxin

Source ID Structure
AlphaFold DB A0A0H3GLP0

References