Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) cptAB/Cpta(toxin)
Location 869641..870298 Replicon chromosome
Accession NZ_CP015990
Organism Klebsiella pneumoniae strain BR

Toxin (Protein)


Gene name cptA Uniprot ID W8UCT0
Locus tag A9J37_RS04340 Protein ID WP_002916310.1
Coordinates 869888..870298 (+) Length 137 a.a.

Antitoxin (Protein)


Gene name cptB Uniprot ID W8UQ37
Locus tag A9J37_RS04335 Protein ID WP_002916312.1
Coordinates 869641..869907 (+) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
A9J37_RS04310 864797..866230 - 1434 WP_020324925.1 6-phospho-beta-glucosidase -
A9J37_RS04315 866349..867077 - 729 WP_002916321.1 MurR/RpiR family transcriptional regulator -
A9J37_RS04320 867127..867438 + 312 WP_004144734.1 N(4)-acetylcytidine aminohydrolase -
A9J37_RS04325 867602..868261 + 660 WP_002916317.1 hemolysin III family protein -
A9J37_RS04330 868412..869395 - 984 WP_020324927.1 tRNA-modifying protein YgfZ -
A9J37_RS04335 869641..869907 + 267 WP_002916312.1 FAD assembly factor SdhE Antitoxin
A9J37_RS04340 869888..870298 + 411 WP_002916310.1 protein YgfX Toxin
A9J37_RS04345 870305..870826 - 522 WP_004144730.1 flavodoxin FldB -
A9J37_RS04350 870927..871823 + 897 WP_004144729.1 site-specific tyrosine recombinase XerD -
A9J37_RS04355 871846..872559 + 714 WP_002916301.1 bifunctional protein-disulfide isomerase/oxidoreductase DsbC -
A9J37_RS04360 872565..874298 + 1734 WP_004149758.1 single-stranded-DNA-specific exonuclease RecJ -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Inner membrane protein YgfX

(3-132)

Antitoxin

Flavinator of succinate dehydrogenase

(7-79)


Sequences

Toxin        


Download         Length: 137 a.a.        Molecular weight: 16049.85 Da        Isoelectric Point: 11.4778

>T64028 WP_002916310.1 NZ_CP015990:869888-870298 [Klebsiella pneumoniae]
VVLWQSDLRISWRAQWFSLLLHGVVAALVLLVPWPLSYTPIWLLLLSLVVFDCVRSQRRIHARRGEIKLLTDSRLRWQNA
EWEILGTPWVINSGMLLRLRHVDTRRGQHLWLAADSMDAGEWRDLRRLVLQKPAQE

Download         Length: 411 bp

>T64028 NZ_CP015990:869888-870298 [Klebsiella pneumoniae]
GTGGTCCTGTGGCAATCTGATCTCCGTATCTCCTGGCGCGCGCAGTGGTTTTCCCTGCTGCTTCACGGCGTGGTGGCGGC
CCTGGTGCTGTTGGTTCCCTGGCCGCTGAGCTATACCCCGATCTGGCTGCTGCTGCTGTCGCTGGTGGTCTTCGACTGCG
TGCGCAGCCAGCGACGGATCCATGCCCGTCGCGGGGAAATAAAACTGCTCACCGATTCCCGTCTTCGCTGGCAAAACGCC
GAATGGGAGATCCTCGGGACGCCGTGGGTTATCAATAGCGGTATGCTGCTGCGTTTGCGCCATGTCGATACCCGGCGCGG
ACAGCATCTTTGGCTGGCGGCGGACAGCATGGACGCCGGAGAGTGGCGCGATCTGCGCCGGCTGGTGCTGCAAAAACCGG
CGCAGGAGTAA

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 10480.98 Da        Isoelectric Point: 5.1116

>AT64028 WP_002916312.1 NZ_CP015990:869641-869907 [Klebsiella pneumoniae]
MDINNKARIHWACRRGMRELDISIMPFFEYEYDTLSDADKQLFIRLLENDDPDLFNWLMNHGKPADAELQRMVTLIQTRN
RERGPVAI

Download         Length: 267 bp

>AT64028 NZ_CP015990:869641-869907 [Klebsiella pneumoniae]
ATGGACATTAACAATAAAGCACGTATCCACTGGGCATGCCGCCGCGGGATGCGCGAACTCGACATCTCCATCATGCCGTT
CTTTGAGTATGAGTACGATACCCTCAGCGACGCTGACAAACAGCTGTTCATTCGCCTGCTGGAAAATGACGATCCGGATC
TGTTCAACTGGCTGATGAACCACGGCAAACCGGCCGATGCGGAGCTGCAGCGGATGGTAACCTTAATTCAGACACGGAAT
CGGGAACGTGGTCCTGTGGCAATCTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0H3GSW7

Antitoxin

Source ID Structure
AlphaFold DB A0A0H3GY41

References