Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/VapC-VapB
Location 2158204..2158769 Replicon chromosome
Accession NZ_CP015986
Organism Sphingobium sp. EP60837

Toxin (Protein)


Gene name vapC Uniprot ID -
Locus tag EP837_RS10460 Protein ID WP_066527191.1
Coordinates 2158204..2158575 (-) Length 124 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID -
Locus tag EP837_RS20500 Protein ID WP_082919612.1
Coordinates 2158572..2158769 (-) Length 66 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
EP837_RS10445 2154311..2155036 - 726 WP_066527183.1 class I SAM-dependent methyltransferase -
EP837_RS10450 2155009..2156025 - 1017 WP_066527185.1 glycosyltransferase family 2 protein -
EP837_RS10455 2156143..2157672 + 1530 WP_066527188.1 YfhO family protein -
EP837_RS10460 2158204..2158575 - 372 WP_066527191.1 type II toxin-antitoxin system VapC family toxin Toxin
EP837_RS20500 2158572..2158769 - 198 WP_082919612.1 type II toxin-antitoxin system VapB family antitoxin Antitoxin
EP837_RS10465 2158909..2159946 - 1038 WP_066527196.1 site-specific integrase -
EP837_RS10475 2160654..2161988 + 1335 WP_066527200.1 dicarboxylate/amino acid:cation symporter -
EP837_RS10480 2161994..2162371 - 378 WP_066527203.1 response regulator -
EP837_RS10485 2162520..2163413 + 894 WP_066529188.1 N-formylglutamate amidohydrolase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(2-112)

Antitoxin

Bacterial antitoxin of type II TA system, VapB

(1-46)


Sequences

Toxin        


Download         Length: 124 a.a.        Molecular weight: 13645.64 Da        Isoelectric Point: 6.3694

>T64022 WP_066527191.1 NZ_CP015986:c2158575-2158204 [Sphingobium sp. EP60837]
MILVDTSVWIDHFRHDDPALARSLDQRQVLSHPFVIGELALGSLRQRDLILEALRGLPSALVAHDDEVHAFIDRHRLFGL
GIGYIDAHLLAATCLTPDACFWTRDKRLRAAASQLGVGATLDQ

Download         Length: 372 bp

>T64022 NZ_CP015986:c2158575-2158204 [Sphingobium sp. EP60837]
ATGATCCTGGTCGATACTTCCGTCTGGATCGATCATTTTCGTCATGATGATCCGGCGCTCGCCCGATCACTCGACCAGCG
GCAGGTTCTTTCCCATCCCTTCGTTATCGGGGAGTTGGCGCTGGGAAGCCTTCGGCAAAGAGATCTCATCCTAGAAGCGC
TTCGCGGATTGCCGTCAGCTCTGGTCGCGCACGATGACGAGGTTCATGCCTTCATTGACCGCCACAGACTGTTCGGCCTG
GGCATCGGCTACATCGATGCACATCTGCTGGCAGCAACGTGTCTGACGCCCGACGCCTGCTTCTGGACACGTGATAAGCG
CTTGAGGGCAGCTGCCTCGCAGCTCGGCGTGGGTGCGACTCTGGATCAGTAG

Antitoxin


Download         Length: 66 a.a.        Molecular weight: 7071.04 Da        Isoelectric Point: 8.9168

>AT64022 WP_082919612.1 NZ_CP015986:c2158769-2158572 [Sphingobium sp. EP60837]
MRTTLALDDELIAKAQSFTGLTEKSALVREALKALIERESAARLSRLGGTEPHSEAAPRRRPDPA

Download         Length: 198 bp

>AT64022 NZ_CP015986:c2158769-2158572 [Sphingobium sp. EP60837]
ATGCGAACTACCCTAGCATTGGATGACGAGCTTATTGCGAAGGCTCAGTCGTTCACCGGCTTGACCGAAAAATCAGCGCT
CGTTCGTGAAGCGCTTAAAGCTCTCATAGAACGGGAGAGCGCCGCACGCCTTTCCCGTCTTGGCGGCACTGAGCCTCATA
GTGAAGCCGCTCCGCGCCGACGTCCCGATCCTGCATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References