Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/VapC-StbC
Location 5327391..5328058 Replicon chromosome
Accession NZ_CP015972
Organism Xanthomonas citri pv. glycines str. 12-2

Toxin (Protein)


Gene name vapC Uniprot ID M4U0C6
Locus tag A9D66_RS24130 Protein ID WP_005916679.1
Coordinates 5327642..5328058 (+) Length 139 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID M4U000
Locus tag A9D66_RS24125 Protein ID WP_005916676.1
Coordinates 5327391..5327645 (+) Length 85 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
A9D66_RS24100 5323497..5323706 + 210 WP_108350128.1 RNA 2'-phosphotransferase -
A9D66_RS24105 5323889..5325154 + 1266 WP_016849472.1 cardiolipin synthase B -
A9D66_RS24110 5325180..5325707 - 528 WP_005916668.1 hypothetical protein -
A9D66_RS24115 5325946..5326152 + 207 WP_003489327.1 hypothetical protein -
A9D66_RS24120 5326139..5327245 + 1107 WP_005916674.1 type II toxin-antitoxin system RelE/ParE family toxin -
A9D66_RS24125 5327391..5327645 + 255 WP_005916676.1 Arc family DNA-binding protein Antitoxin
A9D66_RS24130 5327642..5328058 + 417 WP_005916679.1 type II toxin-antitoxin system VapC family toxin Toxin
A9D66_RS25185 5328180..5328452 - 273 WP_124632111.1 hypothetical protein -
A9D66_RS25190 5328465..5328725 - 261 WP_124632112.1 hypothetical protein -
A9D66_RS24135 5328982..5330601 + 1620 WP_016849230.1 enterochelin esterase -
A9D66_RS24140 5330705..5331103 - 399 WP_004429277.1 DUF2384 domain-containing protein -
A9D66_RS24145 5331419..5331850 + 432 WP_016849229.1 hypothetical protein -
A9D66_RS24150 5331879..5332205 - 327 Protein_4509 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(2-127)

Antitoxin

Arc-like DNA binding domain

(1-39)


Sequences

Toxin        


Download         Length: 139 a.a.        Molecular weight: 14795.09 Da        Isoelectric Point: 5.6920

>T64014 WP_005916679.1 NZ_CP015972:5327642-5328058 [Xanthomonas citri pv. glycines str. 12-2]
VILLDTNVISELWRPQPNPQVVAWIDAQAVETLFLSVVTVAELRFGIAVMPKGRKRSTLHARLEGEVLPLFDGRLLAFDL
DASHAFAALASKARTAGLTLGRADAYIAATAAAQGLTVATRDTAPFEAMALDVINPWS

Download         Length: 417 bp

>T64014 NZ_CP015972:5327642-5328058 [Xanthomonas citri pv. glycines str. 12-2]
GTGATCCTGCTCGATACCAATGTCATCTCCGAACTTTGGCGGCCTCAGCCTAATCCGCAAGTCGTCGCCTGGATCGATGC
ACAAGCTGTCGAGACACTGTTCCTGTCGGTCGTGACGGTGGCTGAACTCCGTTTCGGTATTGCCGTGATGCCCAAGGGCC
GAAAGCGATCCACCTTGCATGCTCGGTTGGAGGGCGAGGTATTGCCACTGTTCGACGGGCGCCTGCTCGCATTCGATCTG
GATGCATCACACGCATTTGCGGCGCTTGCATCGAAAGCCAGAACCGCAGGACTCACACTCGGGCGCGCCGATGCCTACAT
CGCTGCAACGGCAGCCGCGCAAGGATTGACCGTTGCCACTCGCGACACGGCACCATTCGAGGCGATGGCGTTAGACGTCA
TTAACCCTTGGAGTTGA

Antitoxin


Download         Length: 85 a.a.        Molecular weight: 8996.53 Da        Isoelectric Point: 11.3362

>AT64014 WP_005916676.1 NZ_CP015972:5327391-5327645 [Xanthomonas citri pv. glycines str. 12-2]
MPSFTVRNIPDDVHRAIRARAALHGRSTEAEIRAILELAAKPADRVKLGSLLVSIGRDAGLTAKEANAFDKLRGKAAIKP
IGLK

Download         Length: 255 bp

>AT64014 NZ_CP015972:5327391-5327645 [Xanthomonas citri pv. glycines str. 12-2]
ATGCCTTCTTTCACCGTCCGCAATATCCCAGACGACGTGCATCGCGCGATCCGCGCGCGGGCTGCACTTCATGGCCGCAG
CACCGAAGCGGAGATCCGCGCAATCCTTGAATTGGCGGCCAAACCCGCAGACCGGGTCAAACTCGGCTCACTGCTGGTGA
GCATCGGCCGCGACGCCGGCCTGACCGCAAAAGAGGCCAATGCCTTCGACAAGCTGCGCGGCAAGGCGGCGATCAAGCCG
ATCGGTCTGAAGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB M4U0C6

Antitoxin

Source ID Structure
AlphaFold DB A0A828YKJ0

References