Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) PumA-relB/upstrm_HI1419-dnstrm_HI1420
Location 3382187..3382774 Replicon chromosome
Accession NZ_CP015971
Organism Arachidicoccus sp. BS20

Toxin (Protein)


Gene name PumA Uniprot ID A0A191TP02
Locus tag A9P82_RS14705 Protein ID WP_066209135.1
Coordinates 3382475..3382774 (-) Length 100 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID A0A191TP05
Locus tag A9P82_RS14700 Protein ID WP_066209129.1
Coordinates 3382187..3382471 (-) Length 95 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
A9P82_RS14680 3377910..3378626 + 717 WP_066209118.1 LamB/YcsF family protein -
A9P82_RS14685 3378626..3379795 + 1170 WP_066209121.1 divalent metal cation transporter -
A9P82_RS14690 3379850..3380659 + 810 WP_066209125.1 type I methionyl aminopeptidase -
A9P82_RS14695 3380821..3382056 + 1236 WP_066209127.1 NAD(P)/FAD-dependent oxidoreductase -
A9P82_RS14700 3382187..3382471 - 285 WP_066209129.1 putative addiction module antidote protein Antitoxin
A9P82_RS14705 3382475..3382774 - 300 WP_066209135.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
A9P82_RS14710 3383291..3383755 - 465 WP_156522710.1 hypothetical protein -
A9P82_RS14715 3383979..3384818 - 840 WP_066209140.1 class I SAM-dependent methyltransferase -
A9P82_RS14720 3385010..3385645 - 636 WP_082915373.1 dihydrofolate reductase family protein -
A9P82_RS14725 3385666..3386238 - 573 WP_066209143.1 dihydrofolate reductase family protein -
A9P82_RS14730 3386346..3387566 - 1221 WP_066209146.1 site-specific DNA-methyltransferase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Addiction module killer protein, predicted

(1-98)

Antitoxin

Uncharacterized protein HI1420

(3-91)


Sequences

Toxin        


Download         Length: 100 a.a.        Molecular weight: 11741.75 Da        Isoelectric Point: 10.2395

>T64011 WP_066209135.1 NZ_CP015971:c3382774-3382475 [Arachidicoccus sp. BS20]
MYFIEKTAEFDKWLRRLKDLRAKAKILFRIQKLETEEHFGDCKSVGNGISELKINYAKGYRIYFRETDGKIIILLIGGDK
STQQKDIEKAKQIWDKLKK

Download         Length: 300 bp

>T64011 NZ_CP015971:c3382774-3382475 [Arachidicoccus sp. BS20]
ATGTACTTTATTGAAAAAACAGCGGAATTTGACAAGTGGTTAAGAAGATTAAAGGATTTACGAGCAAAAGCAAAAATTTT
GTTTAGAATCCAAAAATTGGAAACCGAAGAACATTTCGGAGATTGTAAATCTGTCGGAAACGGCATTAGTGAATTAAAAA
TTAACTACGCAAAAGGTTATAGAATTTATTTCAGAGAAACAGACGGAAAAATTATAATTCTGCTTATAGGCGGCGATAAA
TCAACACAACAAAAAGACATTGAGAAAGCAAAACAAATTTGGGATAAATTAAAAAAGTAA

Antitoxin


Download         Length: 95 a.a.        Molecular weight: 10105.53 Da        Isoelectric Point: 4.2412

>AT64011 WP_066209129.1 NZ_CP015971:c3382471-3382187 [Arachidicoccus sp. BS20]
METSKFDIADYLDNNEMIAEYLNTVIEEGNDADIINAIGNIAKAIGMTKIAEETGLSRPSLYKALSDGAKPQFTTIMKVL
KAVGGQIQVNPISA

Download         Length: 285 bp

>AT64011 NZ_CP015971:c3382471-3382187 [Arachidicoccus sp. BS20]
ATGGAAACTTCAAAATTTGACATAGCAGATTATTTAGACAACAACGAAATGATTGCGGAATATCTTAACACGGTTATAGA
AGAAGGCAATGATGCTGATATAATTAATGCTATTGGAAATATTGCAAAAGCAATCGGGATGACAAAAATTGCAGAAGAAA
CAGGTCTAAGCCGACCAAGTCTATACAAAGCGCTGTCCGACGGAGCAAAACCTCAATTTACAACTATAATGAAAGTTTTG
AAAGCCGTTGGCGGACAAATACAGGTTAATCCAATAAGCGCTTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A191TP02

Antitoxin

Source ID Structure
AlphaFold DB A0A191TP05

References