Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | vapBC/PHD(antitoxin) |
| Location | 2547171..2547853 | Replicon | chromosome |
| Accession | NZ_CP015970 | ||
| Organism | Acidipropionibacterium acidipropionici strain F3E8 | ||
Toxin (Protein)
| Gene name | vapC | Uniprot ID | - |
| Locus tag | A8L58_RS11750 | Protein ID | WP_062819791.1 |
| Coordinates | 2547171..2547590 (-) | Length | 140 a.a. |
Antitoxin (Protein)
| Gene name | vapB | Uniprot ID | K7SF30 |
| Locus tag | A8L58_RS11755 | Protein ID | WP_015068797.1 |
| Coordinates | 2547590..2547853 (-) | Length | 88 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| A8L58_RS11705 | 2542174..2542557 | + | 384 | WP_015068789.1 | D-ribose pyranase | - |
| A8L58_RS11710 | 2542575..2543336 | - | 762 | WP_062819787.1 | ABC transporter permease | - |
| A8L58_RS11715 | 2543333..2544136 | - | 804 | WP_062819788.1 | ATP-binding cassette domain-containing protein | - |
| A8L58_RS11720 | 2544133..2544540 | - | 408 | WP_126133026.1 | DUF1048 domain-containing protein | - |
| A8L58_RS11725 | 2544540..2544857 | - | 318 | WP_198401494.1 | PadR family transcriptional regulator | - |
| A8L58_RS11730 | 2545019..2545936 | - | 918 | WP_082815990.1 | SDR family oxidoreductase | - |
| A8L58_RS11740 | 2546329..2546697 | + | 369 | WP_099093033.1 | type II toxin-antitoxin system RelE/ParE family toxin | - |
| A8L58_RS11745 | 2546697..2547008 | + | 312 | WP_081685418.1 | helix-turn-helix domain-containing protein | - |
| A8L58_RS11750 | 2547171..2547590 | - | 420 | WP_062819791.1 | type II toxin-antitoxin system VapC family toxin | Toxin |
| A8L58_RS11755 | 2547590..2547853 | - | 264 | WP_015068797.1 | type II toxin-antitoxin system prevent-host-death family antitoxin | Antitoxin |
| A8L58_RS11760 | 2547975..2548241 | - | 267 | WP_015068798.1 | hypothetical protein | - |
| A8L58_RS11765 | 2548471..2548920 | + | 450 | WP_062819792.1 | CBS domain-containing protein | - |
| A8L58_RS11770 | 2548973..2550265 | + | 1293 | WP_062820775.1 | ArsB/NhaD family transporter | - |
| A8L58_RS11775 | 2550247..2550768 | - | 522 | WP_062819793.1 | MFS transporter | - |
| A8L58_RS11780 | 2550702..2551559 | - | 858 | WP_062819794.1 | MFS transporter | - |
| A8L58_RS11785 | 2551829..2552638 | - | 810 | WP_071001126.1 | tyrosine-protein phosphatase | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 140 a.a. Molecular weight: 15033.29 Da Isoelectric Point: 4.9147
>T64010 WP_062819791.1 NZ_CP015970:c2547590-2547171 [Acidipropionibacterium acidipropionici]
MFYADTSALVKLVVIEPESGALLDWLGHRDAALATSDLARTELVRSMRRRAPEAITQARDVLSRLLLVRADAQIFDEAAR
LMPPEVRSLDAVHLATALALGDDLEGVITYNLRMADAAHGLGLEVAAPGTPRNPQPNII
MFYADTSALVKLVVIEPESGALLDWLGHRDAALATSDLARTELVRSMRRRAPEAITQARDVLSRLLLVRADAQIFDEAAR
LMPPEVRSLDAVHLATALALGDDLEGVITYNLRMADAAHGLGLEVAAPGTPRNPQPNII
Download Length: 420 bp
>T64010 NZ_CP015970:c2547590-2547171 [Acidipropionibacterium acidipropionici]
ATGTTCTACGCGGACACCTCTGCACTGGTGAAACTCGTCGTCATCGAGCCGGAGTCCGGAGCCCTGCTGGACTGGCTCGG
ACACCGCGACGCCGCCCTGGCGACCAGCGACCTCGCCCGCACCGAGCTGGTGCGCTCCATGCGCCGCAGGGCTCCAGAGG
CCATCACGCAGGCCCGCGACGTGCTGTCACGACTGCTCCTGGTGAGGGCCGATGCCCAGATCTTCGACGAAGCCGCACGT
CTCATGCCGCCAGAGGTTCGAAGTCTCGACGCCGTGCATCTCGCCACGGCACTGGCACTGGGGGACGATCTCGAGGGAGT
CATCACCTACAACCTCCGGATGGCCGACGCCGCCCACGGCCTGGGGCTGGAGGTCGCCGCACCGGGGACACCACGAAACC
CCCAGCCAAACATCATTTGA
ATGTTCTACGCGGACACCTCTGCACTGGTGAAACTCGTCGTCATCGAGCCGGAGTCCGGAGCCCTGCTGGACTGGCTCGG
ACACCGCGACGCCGCCCTGGCGACCAGCGACCTCGCCCGCACCGAGCTGGTGCGCTCCATGCGCCGCAGGGCTCCAGAGG
CCATCACGCAGGCCCGCGACGTGCTGTCACGACTGCTCCTGGTGAGGGCCGATGCCCAGATCTTCGACGAAGCCGCACGT
CTCATGCCGCCAGAGGTTCGAAGTCTCGACGCCGTGCATCTCGCCACGGCACTGGCACTGGGGGACGATCTCGAGGGAGT
CATCACCTACAACCTCCGGATGGCCGACGCCGCCCACGGCCTGGGGCTGGAGGTCGCCGCACCGGGGACACCACGAAACC
CCCAGCCAAACATCATTTGA
Antitoxin
Download Length: 88 a.a. Molecular weight: 9390.67 Da Isoelectric Point: 10.3568
>AT64010 WP_015068797.1 NZ_CP015970:c2547853-2547590 [Acidipropionibacterium acidipropionici]
MSEVGIRELKQNASSVVRRAAAGEEITVTDRGRPVARLSAIDHGGVRGLLAADRARPPIRALSDLPAPTIAADVSSVLRQ
MRDEERY
MSEVGIRELKQNASSVVRRAAAGEEITVTDRGRPVARLSAIDHGGVRGLLAADRARPPIRALSDLPAPTIAADVSSVLRQ
MRDEERY
Download Length: 264 bp
>AT64010 NZ_CP015970:c2547853-2547590 [Acidipropionibacterium acidipropionici]
ATGAGTGAGGTCGGCATCCGCGAGTTGAAGCAGAACGCCTCGAGCGTCGTCCGCCGGGCCGCCGCTGGCGAGGAGATCAC
GGTGACCGATCGGGGTCGGCCGGTCGCGCGACTCTCCGCCATCGATCACGGCGGAGTGCGCGGGCTGCTCGCCGCCGACC
GGGCCCGCCCACCGATCCGGGCACTGAGCGATCTCCCCGCGCCCACGATCGCCGCCGACGTCTCCTCGGTTCTCCGGCAG
ATGCGCGACGAGGAGCGCTACTGA
ATGAGTGAGGTCGGCATCCGCGAGTTGAAGCAGAACGCCTCGAGCGTCGTCCGCCGGGCCGCCGCTGGCGAGGAGATCAC
GGTGACCGATCGGGGTCGGCCGGTCGCGCGACTCTCCGCCATCGATCACGGCGGAGTGCGCGGGCTGCTCGCCGCCGACC
GGGCCCGCCCACCGATCCGGGCACTGAGCGATCTCCCCGCGCCCACGATCGCCGCCGACGTCTCCTCGGTTCTCCGGCAG
ATGCGCGACGAGGAGCGCTACTGA
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|