64007

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/VapC(toxin)
Location 1724124..1724764 Replicon chromosome
Accession NZ_CP015970
Organism Acidipropionibacterium acidipropionici strain F3E8

Toxin (Protein)


Gene name vapC Uniprot ID A0A3S5HP76
Locus tag A8L58_RS08225 Protein ID WP_062819382.1
Coordinates 1724372..1724764 (+) Length 131 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID K7S7C8
Locus tag A8L58_RS08220 Protein ID WP_015071399.1
Coordinates 1724124..1724375 (+) Length 84 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
A8L58_RS08205 1720060..1720992 + 933 WP_062819380.1 hydrogen peroxide-inducible genes activator -
A8L58_RS08210 1721095..1722528 - 1434 WP_062819381.1 adenylosuccinate lyase -
A8L58_RS08215 1722590..1723909 - 1320 WP_062820686.1 phosphoribosylamine--glycine ligase -
A8L58_RS08220 1724124..1724375 + 252 WP_015071399.1 type II toxin-antitoxin system VapB family antitoxin Antitoxin
A8L58_RS08225 1724372..1724764 + 393 WP_062819382.1 type II toxin-antitoxin system VapC family toxin Toxin
A8L58_RS08230 1724966..1726252 - 1287 WP_015071401.1 adenylosuccinate synthase -
A8L58_RS08235 1726457..1727323 - 867 WP_015071402.1 GNAT family N-acetyltransferase -
A8L58_RS08240 1727384..1728085 - 702 WP_071001097.1 DUF3151 family protein -
A8L58_RS08245 1728237..1728527 + 291 WP_198401452.1 metal-sensitive transcriptional regulator -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(1-124)

Antitoxin

Antitoxin VapB-like

(1-82)


Sequences

Toxin        


Download         Length: 131 a.a.        Molecular weight: 13530.30 Da        Isoelectric Point: 4.0038

>T64007 WP_062819382.1 NZ_CP015970:1724372-1724764 [Acidipropionibacterium acidipropionici]
MIVDTSALVAVLTGEPDAEHLLDVMIGADRLALSAASLVEASVVLEARAGSEAVADLHALLADLDTEVLPCDETQAITAA
QAWSRFGKGRHPAALNLGDLFSYAAAITQGESLLFKGDAFPQTDIVVADR

Download         Length: 393 bp

>T64007 NZ_CP015970:1724372-1724764 [Acidipropionibacterium acidipropionici]
ATGATCGTCGACACGTCTGCCCTGGTGGCCGTACTCACAGGAGAGCCCGACGCCGAGCACCTGCTTGACGTCATGATCGG
CGCCGACCGCCTGGCATTGAGCGCCGCCAGCCTGGTTGAGGCTTCTGTCGTTCTCGAGGCACGCGCTGGATCCGAGGCGG
TGGCCGATCTTCACGCGCTACTGGCCGACCTCGACACGGAAGTCCTGCCGTGTGACGAGACCCAGGCGATCACAGCAGCT
CAGGCATGGAGCCGTTTCGGGAAGGGGCGTCACCCTGCTGCGCTGAACCTCGGCGACTTGTTCTCATATGCCGCCGCAAT
TACTCAGGGAGAGTCACTTCTCTTCAAGGGCGACGCCTTCCCACAAACCGACATCGTGGTAGCCGATCGGTGA

Antitoxin


Download         Length: 84 a.a.        Molecular weight: 9500.56 Da        Isoelectric Point: 6.0829

>AT64007 WP_015071399.1 NZ_CP015970:1724124-1724375 [Acidipropionibacterium acidipropionici]
MALNIKDPDTDRLARELAEETGETLTSALHAALAERLTRVRRQHRVSSRPDLHHYIERARARAVLDDRDADEIIGYDENG
LPR

Download         Length: 252 bp

>AT64007 NZ_CP015970:1724124-1724375 [Acidipropionibacterium acidipropionici]
ATGGCGCTCAACATCAAGGACCCGGACACCGACCGGCTGGCCCGTGAACTTGCAGAGGAGACCGGCGAGACCCTCACCTC
TGCGCTGCACGCCGCCCTGGCTGAACGCTTGACACGAGTGCGCCGTCAGCACCGGGTCTCCTCCCGGCCCGATCTGCATC
ACTACATCGAACGCGCGCGAGCCAGGGCCGTGCTCGATGATCGCGACGCCGACGAGATCATCGGCTATGACGAGAACGGC
CTGCCACGATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A3S5HP76

Antitoxin

Source ID Structure
AlphaFold DB K7S7C8

References