Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) pemIK/PRK09907-MazE
Location 1751..2352 Replicon plasmid LZ206p1
Accession NZ_CP015968
Organism Lactiplantibacillus plantarum strain LZ206

Toxin (Protein)


Gene name pemK Uniprot ID Q684P1
Locus tag A9F05_RS15355 Protein ID WP_001748110.1
Coordinates 2008..2352 (+) Length 115 a.a.

Antitoxin (Protein)


Gene name pemI Uniprot ID A0A806J926
Locus tag A9F05_RS15350 Protein ID WP_001748109.1
Coordinates 1751..2014 (+) Length 88 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
A9F05_RS16290 568..735 - 168 WP_127064551.1 hypothetical protein -
A9F05_RS15345 1090..1665 - 576 WP_064523825.1 site-specific integrase -
A9F05_RS15350 1751..2014 + 264 WP_001748109.1 AbrB/MazE/SpoVT family DNA-binding domain-containing protein Antitoxin
A9F05_RS15355 2008..2352 + 345 WP_001748110.1 type II toxin-antitoxin system PemK/MazF family toxin Toxin
A9F05_RS15360 2471..3801 - 1331 Protein_4 NAD(P)/FAD-dependent oxidoreductase -
A9F05_RS15365 3963..4610 - 648 WP_064523828.1 DsbA family oxidoreductase -
A9F05_RS15370 4629..5572 - 944 Protein_6 thioredoxin-disulfide reductase -
A9F05_RS16175 5657..5791 - 135 WP_080280589.1 aspartate/glutamate racemase family protein -
A9F05_RS15375 5791..6096 - 306 WP_164969426.1 thioredoxin family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Non-Mobilizable plasmid - - 1..6111 6111


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase PemK-like

(1-104)

Antitoxin

Antitoxin PemI-like

(8-85)


Sequences

Toxin        


Download         Length: 115 a.a.        Molecular weight: 13041.89 Da        Isoelectric Point: 6.4782

>T64005 WP_001748110.1 NZ_CP015968:2008-2352 [Lactiplantibacillus plantarum]
MVSQGDIFYVNFNPSRGHEQMNKRPAIALSNDLVCQTSNMTIVAPISSTKRNFPMYHRLTSSQTVYGKVLLDQTIALDLR
ARHVTDETIVDHVSREELEEIITLYKLLFSIDDK

Download         Length: 345 bp

>T64005 NZ_CP015968:2008-2352 [Lactiplantibacillus plantarum]
ATGGTAAGCCAAGGTGATATATTTTATGTTAACTTTAATCCAAGCCGTGGTCATGAACAGATGAATAAGCGACCAGCCAT
TGCTCTAAGCAATGATTTAGTCTGTCAGACAAGTAACATGACGATTGTGGCTCCAATTAGCAGTACCAAGCGTAATTTTC
CAATGTATCATCGACTAACTAGTAGCCAAACAGTATATGGAAAAGTATTATTAGATCAAACCATAGCCTTAGACTTACGG
GCAAGACATGTCACTGATGAAACTATTGTCGATCATGTATCGCGTGAAGAACTAGAAGAAATAATCACTTTGTACAAATT
ATTGTTTAGTATTGATGACAAATAG

Antitoxin


Download         Length: 88 a.a.        Molecular weight: 10141.47 Da        Isoelectric Point: 5.7117

>AT64005 WP_001748109.1 NZ_CP015968:1751-2014 [Lactiplantibacillus plantarum]
MELIKEQTRLAKWGNSKAARIPSQIIKQLKLDDNQDMTITIENGSIVLTPIKKNPTNIHELFKDWQDDGKRDHELDWGKS
EGNELQW

Download         Length: 264 bp

>AT64005 NZ_CP015968:1751-2014 [Lactiplantibacillus plantarum]
ATGGAACTTATTAAAGAACAAACACGCTTAGCAAAGTGGGGAAACTCGAAAGCTGCTAGAATTCCTAGCCAAATTATTAA
ACAACTGAAATTAGATGATAACCAAGATATGACAATAACCATTGAAAATGGATCAATTGTTTTAACACCAATAAAAAAGA
ACCCAACCAATATTCACGAACTATTTAAGGATTGGCAAGATGACGGGAAAAGGGATCACGAGCTTGATTGGGGAAAGTCA
GAAGGTAATGAACTTCAATGGTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0R2K1X3

Antitoxin

Source ID Structure
AlphaFold DB A0A806J926

References