Detailed information of TA system TA064001

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): relBE/RelE-Phd
• Location: 1143055..1143599
• Replicon: chromosome
• Accession: NZ_CP015965
• Organism: Mycobacterium intracellulare subsp. yongonense strain Asan 36527

Toxin (Protein)

• Gene name: relE
• Uniprot ID: -
• Locus tag: MOTT27_RS05735
• Protein ID: WP_036455529.1
• Coordinates: 1143354..1143599 (+)
• Length: 82 a.a.

Antitoxin (Protein)

• Gene name: relB
• Uniprot ID: S4Z4W6
• Locus tag: MOTT27_RS05730
• Protein ID: WP_020821851.1
• Coordinates: 1143055..1143339 (+)
• Length: 95 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
MOTT27_RS05715	1139085..1140158	+	1074	WP_008254380.1	redox-regulated ATPase YchF	-
MOTT27_RS05720	1140175..1140915	+	741	WP_036454796.1	aminoglycoside 3'-phosphotransferase	-
MOTT27_RS05725	1141030..1142847	+	1818	WP_162288420.1	transposase	-
MOTT27_RS05730	1143055..1143339	+	285	WP_020821851.1	type II toxin-antitoxin system Phd/YefM family antitoxin	Antitoxin
MOTT27_RS05735	1143354..1143599	+	246	WP_036455529.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
MOTT27_RS05740	1143635..1144186	+	552	WP_036454798.1	VOC family protein	-
MOTT27_RS05745	1144265..1144663	+	399	WP_036454800.1	VOC family protein	-
MOTT27_RS05750	1144758..1144955	+	198	WP_036455532.1	type II toxin-antitoxin system VapB family antitoxin	-
MOTT27_RS05755	1144952..1145320	+	369	WP_036454801.1	type II toxin-antitoxin system VapC family toxin	-
MOTT27_RS05760	1145503..1145844	+	342	WP_179945069.1	hypothetical protein	-
MOTT27_RS25940	1145930..1146289	+	360	WP_042910935.1	hypothetical protein	-
MOTT27_RS05770	1146474..1147009	+	536	Protein_1125	C40 family peptidase	-
MOTT27_RS05775	1147371..1147694	+	324	WP_036454806.1	antibiotic biosynthesis monooxygenase	-
MOTT27_RS05780	1147732..1148565	-	834	WP_036454808.1	SAM-dependent methyltransferase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, RelE/ParE toxin family (29-80)

Antitoxin

• Type II toxin-antitoxin system, antitoxin Phd/YefM (1-71)

Sequences

Toxin

Protein

• Length: 82 a.a.
• Molecular weight: 9440.03 Da
• Isoelectric Point: 11.5482

>T64001 WP_036455529.1 NZ_CP015965:1143354-1143599 [Mycobacterium intracellulare subsp. yongonense]
MTAAAKRALTHLLPESVAIACWEFIRGPLAENPQRVGKPLRGQLEGRYSARRGEFRVIYRIFDERVVVRVIHIAHRRDVY
R

Nucleotide

• Length: 246 bp

>T64001 NZ_CP015965:1143354-1143599 [Mycobacterium intracellulare subsp. yongonense]
ATGACGGCAGCTGCGAAGAGGGCGCTCACTCATTTGTTGCCCGAGTCAGTGGCCATTGCTTGCTGGGAGTTCATTCGGGG
TCCGCTCGCGGAGAACCCGCAGCGGGTGGGCAAGCCGCTTCGCGGCCAGTTGGAAGGGCGATACTCGGCGCGCAGGGGCG
AGTTTCGCGTCATTTACCGGATCTTCGACGAACGGGTGGTGGTCCGCGTCATCCACATCGCGCATCGCCGCGACGTTTAC
CGGTGA

Antitoxin

Protein

• Length: 95 a.a.
• Molecular weight: 10513.88 Da
• Isoelectric Point: 4.3705

>AT64001 WP_020821851.1 NZ_CP015965:1143055-1143339 [Mycobacterium intracellulare subsp. yongonense]
MSTLPLAEVRANLSKLVDEAVRTHERIEVTRQGRRAAVILSADDFDSIMETLAILSDQDLMREVRAAESEAEDGALYTLD
QVTEEMRAVGRLPR

Nucleotide

• Length: 285 bp

>AT64001 NZ_CP015965:1143055-1143339 [Mycobacterium intracellulare subsp. yongonense]
ATGTCGACGCTTCCGCTGGCCGAGGTCCGAGCCAACCTTTCCAAGCTGGTCGACGAGGCCGTCCGGACCCATGAGCGCAT
CGAGGTCACCAGGCAAGGTCGCCGCGCGGCGGTGATTCTCAGCGCGGATGACTTCGATTCGATTATGGAAACTCTGGCCA
TCCTCAGCGATCAAGACTTGATGCGCGAAGTCCGAGCGGCAGAGTCAGAGGCAGAGGACGGCGCGCTCTACACACTCGAT
CAGGTGACCGAGGAGATGCGTGCTGTCGGCCGGCTCCCGCGGTGA

Structures

Antitoxin

• AlphaFold DB: S4Z4W6