Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | pezAT/zeta-ParD |
| Location | 2418697..2419689 | Replicon | chromosome |
| Accession | NZ_CP015964 | ||
| Organism | Mycobacterium intracellulare subsp. yongonense strain Asan 36912 | ||
Toxin (Protein)
| Gene name | pezT | Uniprot ID | S4ZAV9 |
| Locus tag | MOTT12_RS11430 | Protein ID | WP_014711570.1 |
| Coordinates | 2419111..2419689 (+) | Length | 193 a.a. |
Antitoxin (Protein)
| Gene name | pezA | Uniprot ID | I2ADH5 |
| Locus tag | MOTT12_RS11425 | Protein ID | WP_008256419.1 |
| Coordinates | 2418697..2419086 (+) | Length | 130 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| MOTT12_RS11405 | 2413848..2414516 | - | 669 | WP_179945108.1 | hypothetical protein | - |
| MOTT12_RS11410 | 2414596..2416113 | + | 1518 | WP_014711567.1 | carboxylesterase/lipase family protein | - |
| MOTT12_RS11415 | 2416132..2418135 | + | 2004 | WP_014711568.1 | phosphotransferase | - |
| MOTT12_RS11420 | 2418132..2418626 | + | 495 | WP_014711569.1 | gluconokinase | - |
| MOTT12_RS11425 | 2418697..2419086 | + | 390 | WP_008256419.1 | hypothetical protein | Antitoxin |
| MOTT12_RS11430 | 2419111..2419689 | + | 579 | WP_014711570.1 | zeta toxin family protein | Toxin |
| MOTT12_RS11435 | 2419699..2420766 | - | 1068 | WP_020822441.1 | DoxX family membrane protein | - |
| MOTT12_RS11440 | 2420862..2421422 | + | 561 | WP_014711572.1 | pyrazinamidase PncA | - |
| MOTT12_RS11445 | 2421422..2422222 | + | 801 | WP_020822443.1 | nuclear transport factor 2 family protein | - |
| MOTT12_RS11450 | 2422234..2422584 | - | 351 | WP_008256426.1 | DoxX family protein | - |
| MOTT12_RS11455 | 2422750..2423721 | + | 972 | WP_020822445.1 | sigma-70 family RNA polymerase sigma factor | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 193 a.a. Molecular weight: 21009.00 Da Isoelectric Point: 11.0233
>T63998 WP_014711570.1 NZ_CP015964:2419111-2419689 [Mycobacterium intracellulare subsp. yongonense]
MQRLDLVVGPNGAGKSTFIAFTLAPLLPGSPVVNADEIARQRWPGESAGRAYEAAQIAADTRAKLIDLGRSFIAETVFSH
PSKLDLIRTAHRAGFTVVLHAMLIPEDLAVERVRHRVRAGGHDVPETKVRERHRRLWTPVTDAIALSDVATVYDNSRLRG
PRIVARLTGGTTIGSPDWPAWTPGALRSRWAD
MQRLDLVVGPNGAGKSTFIAFTLAPLLPGSPVVNADEIARQRWPGESAGRAYEAAQIAADTRAKLIDLGRSFIAETVFSH
PSKLDLIRTAHRAGFTVVLHAMLIPEDLAVERVRHRVRAGGHDVPETKVRERHRRLWTPVTDAIALSDVATVYDNSRLRG
PRIVARLTGGTTIGSPDWPAWTPGALRSRWAD
Download Length: 579 bp
>T63998 NZ_CP015964:2419111-2419689 [Mycobacterium intracellulare subsp. yongonense]
ATGCAGCGACTTGACCTGGTGGTCGGGCCGAACGGTGCCGGCAAGTCGACCTTCATCGCGTTCACCCTGGCGCCGCTGTT
GCCCGGCAGCCCGGTCGTCAACGCCGACGAAATCGCAAGGCAGCGCTGGCCGGGGGAGTCGGCGGGGCGCGCCTACGAGG
CCGCGCAAATCGCCGCCGACACGCGCGCGAAGTTGATCGACCTGGGGCGGTCGTTTATCGCGGAGACCGTGTTTTCCCAC
CCGTCGAAGCTGGACCTCATCCGCACCGCCCACCGAGCGGGCTTCACCGTCGTCCTGCACGCGATGCTCATCCCGGAAGA
CCTTGCCGTCGAACGTGTCCGGCACCGCGTGCGGGCCGGCGGCCACGACGTACCGGAAACCAAGGTCCGAGAGCGCCATC
GTCGCTTGTGGACGCCAGTCACCGACGCCATCGCGCTGTCCGACGTCGCCACCGTCTACGACAACAGCCGCCTTCGCGGG
CCGCGCATCGTCGCCCGCCTCACCGGCGGCACGACGATCGGTTCACCGGACTGGCCCGCGTGGACGCCAGGGGCCTTGCG
GTCACGCTGGGCGGACTAA
ATGCAGCGACTTGACCTGGTGGTCGGGCCGAACGGTGCCGGCAAGTCGACCTTCATCGCGTTCACCCTGGCGCCGCTGTT
GCCCGGCAGCCCGGTCGTCAACGCCGACGAAATCGCAAGGCAGCGCTGGCCGGGGGAGTCGGCGGGGCGCGCCTACGAGG
CCGCGCAAATCGCCGCCGACACGCGCGCGAAGTTGATCGACCTGGGGCGGTCGTTTATCGCGGAGACCGTGTTTTCCCAC
CCGTCGAAGCTGGACCTCATCCGCACCGCCCACCGAGCGGGCTTCACCGTCGTCCTGCACGCGATGCTCATCCCGGAAGA
CCTTGCCGTCGAACGTGTCCGGCACCGCGTGCGGGCCGGCGGCCACGACGTACCGGAAACCAAGGTCCGAGAGCGCCATC
GTCGCTTGTGGACGCCAGTCACCGACGCCATCGCGCTGTCCGACGTCGCCACCGTCTACGACAACAGCCGCCTTCGCGGG
CCGCGCATCGTCGCCCGCCTCACCGGCGGCACGACGATCGGTTCACCGGACTGGCCCGCGTGGACGCCAGGGGCCTTGCG
GTCACGCTGGGCGGACTAA
Antitoxin
Download Length: 130 a.a. Molecular weight: 13518.97 Da Isoelectric Point: 5.1668
>AT63998 WP_008256419.1 NZ_CP015964:2418697-2419086 [Mycobacterium intracellulare subsp. yongonense]
MADAPDRVTRVASDLMDSAASEGARQSRSAKQQLDHWARVGRAVSSQHTASRRRVEAAMAGQLATGELTVEEGVVFNAEI
SAAIEESLVHANYGATLAGHGVTTVALNEDGDIVEHLPDGAAVMLARGR
MADAPDRVTRVASDLMDSAASEGARQSRSAKQQLDHWARVGRAVSSQHTASRRRVEAAMAGQLATGELTVEEGVVFNAEI
SAAIEESLVHANYGATLAGHGVTTVALNEDGDIVEHLPDGAAVMLARGR
Download Length: 390 bp
>AT63998 NZ_CP015964:2418697-2419086 [Mycobacterium intracellulare subsp. yongonense]
ATGGCCGACGCTCCCGATCGTGTGACCCGGGTGGCGTCCGACCTGATGGACAGCGCGGCCTCCGAAGGCGCCCGCCAGAG
CCGTTCGGCCAAGCAGCAACTCGACCACTGGGCGCGTGTCGGGCGCGCGGTGTCCAGCCAGCACACCGCCTCGCGTCGGC
GGGTCGAGGCCGCGATGGCCGGCCAGCTGGCGACCGGCGAACTCACCGTCGAGGAAGGCGTGGTGTTCAACGCCGAGATC
TCCGCGGCTATTGAAGAAAGCCTGGTGCACGCCAACTACGGGGCGACGCTGGCCGGGCATGGGGTCACCACGGTCGCCCT
CAACGAGGACGGCGACATCGTCGAGCACCTGCCCGATGGCGCCGCCGTAATGCTGGCGCGCGGGCGCTGA
ATGGCCGACGCTCCCGATCGTGTGACCCGGGTGGCGTCCGACCTGATGGACAGCGCGGCCTCCGAAGGCGCCCGCCAGAG
CCGTTCGGCCAAGCAGCAACTCGACCACTGGGCGCGTGTCGGGCGCGCGGTGTCCAGCCAGCACACCGCCTCGCGTCGGC
GGGTCGAGGCCGCGATGGCCGGCCAGCTGGCGACCGGCGAACTCACCGTCGAGGAAGGCGTGGTGTTCAACGCCGAGATC
TCCGCGGCTATTGAAGAAAGCCTGGTGCACGCCAACTACGGGGCGACGCTGGCCGGGCATGGGGTCACCACGGTCGCCCT
CAACGAGGACGGCGACATCGTCGAGCACCTGCCCGATGGCGCCGCCGTAATGCTGGCGCGCGGGCGCTGA
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|