Detailed information of TA system TA063996

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): relBE/RelE-Phd
• Location: 1145704..1146248
• Replicon: chromosome
• Accession: NZ_CP015964
• Organism: Mycobacterium intracellulare subsp. yongonense strain Asan 36912

Toxin (Protein)

• Gene name: relE
• Uniprot ID: -
• Locus tag: MOTT12_RS05745
• Protein ID: WP_036455529.1
• Coordinates: 1146003..1146248 (+)
• Length: 82 a.a.

Antitoxin (Protein)

• Gene name: relB
• Uniprot ID: S4Z4W6
• Locus tag: MOTT12_RS05740
• Protein ID: WP_020821851.1
• Coordinates: 1145704..1145988 (+)
• Length: 95 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
MOTT12_RS05720	1141735..1142808	+	1074	WP_008254380.1	redox-regulated ATPase YchF	-
MOTT12_RS05725	1142825..1143565	+	741	WP_036454796.1	aminoglycoside 3'-phosphotransferase	-
MOTT12_RS05735	1144306..1145496	+	1191	WP_197095509.1	transposase	-
MOTT12_RS05740	1145704..1145988	+	285	WP_020821851.1	type II toxin-antitoxin system Phd/YefM family antitoxin	Antitoxin
MOTT12_RS05745	1146003..1146248	+	246	WP_036455529.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
MOTT12_RS05750	1146284..1146835	+	552	WP_036454798.1	VOC family protein	-
MOTT12_RS05755	1146914..1147312	+	399	WP_036454800.1	VOC family protein	-
MOTT12_RS05760	1147407..1147604	+	198	WP_036455532.1	type II toxin-antitoxin system VapB family antitoxin	-
MOTT12_RS05765	1147601..1147969	+	369	WP_036454801.1	type II toxin-antitoxin system VapC family toxin	-
MOTT12_RS05770	1148152..1148493	+	342	WP_179945069.1	hypothetical protein	-
MOTT12_RS25710	1148579..1148938	+	360	WP_042910935.1	hypothetical protein	-
MOTT12_RS05780	1149123..1149698	+	576	WP_075630262.1	C40 family peptidase	-
MOTT12_RS05785	1150060..1150383	+	324	WP_036454806.1	antibiotic biosynthesis monooxygenase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, RelE/ParE toxin family (29-80)

Antitoxin

• Type II toxin-antitoxin system, antitoxin Phd/YefM (1-71)

Sequences

Toxin

Protein

• Length: 82 a.a.
• Molecular weight: 9440.03 Da
• Isoelectric Point: 11.5482

>T63996 WP_036455529.1 NZ_CP015964:1146003-1146248 [Mycobacterium intracellulare subsp. yongonense]
MTAAAKRALTHLLPESVAIACWEFIRGPLAENPQRVGKPLRGQLEGRYSARRGEFRVIYRIFDERVVVRVIHIAHRRDVY
R

Nucleotide

• Length: 246 bp

>T63996 NZ_CP015964:1146003-1146248 [Mycobacterium intracellulare subsp. yongonense]
ATGACGGCAGCTGCGAAGAGGGCGCTCACTCATTTGTTGCCCGAGTCAGTGGCCATTGCTTGCTGGGAGTTCATTCGGGG
TCCGCTCGCGGAGAACCCGCAGCGGGTGGGCAAGCCGCTTCGCGGCCAGTTGGAAGGGCGATACTCGGCGCGCAGGGGCG
AGTTTCGCGTCATTTACCGGATCTTCGACGAACGGGTGGTGGTCCGCGTCATCCACATCGCGCATCGCCGCGACGTTTAC
CGGTGA

Antitoxin

Protein

• Length: 95 a.a.
• Molecular weight: 10513.88 Da
• Isoelectric Point: 4.3705

>AT63996 WP_020821851.1 NZ_CP015964:1145704-1145988 [Mycobacterium intracellulare subsp. yongonense]
MSTLPLAEVRANLSKLVDEAVRTHERIEVTRQGRRAAVILSADDFDSIMETLAILSDQDLMREVRAAESEAEDGALYTLD
QVTEEMRAVGRLPR

Nucleotide

• Length: 285 bp

>AT63996 NZ_CP015964:1145704-1145988 [Mycobacterium intracellulare subsp. yongonense]
ATGTCGACGCTTCCGCTGGCCGAGGTCCGAGCCAACCTTTCCAAGCTGGTCGACGAGGCCGTCCGGACCCATGAGCGCAT
CGAGGTCACCAGGCAAGGTCGCCGCGCGGCGGTGATTCTCAGCGCGGATGACTTCGATTCGATTATGGAAACTCTGGCCA
TCCTCAGCGATCAAGACTTGATGCGCGAAGTCCGAGCGGCAGAGTCAGAGGCAGAGGACGGCGCGCTCTACACACTCGAT
CAGGTGACCGAGGAGATGCGTGCTGTCGGCCGGCTCCCGCGGTGA

Structures

Antitoxin

• AlphaFold DB: S4Z4W6