Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/VapC-StbC
Location 2270704..2271359 Replicon chromosome
Accession NZ_CP015961
Organism Dietzia timorensis strain ID05-A0528

Toxin (Protein)


Gene name vapC Uniprot ID A0A173LMN6
Locus tag BJL86_RS10420 Protein ID WP_067474685.1
Coordinates 2270704..2271129 (-) Length 142 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID A0A173LMJ7
Locus tag BJL86_RS10425 Protein ID WP_067474687.1
Coordinates 2271126..2271359 (-) Length 78 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
BJL86_RS10390 2266679..2266963 - 285 WP_067474720.1 preprotein translocase -
BJL86_RS10395 2267075..2267638 + 564 WP_067474675.1 1-acyl-sn-glycerol-3-phosphate acyltransferase -
BJL86_RS10400 2267700..2268104 + 405 WP_067474678.1 NAD(+)--rifampin ADP-ribosyltransferase -
BJL86_RS10405 2268198..2268551 - 354 Protein_2031 DUF1801 domain-containing protein -
BJL86_RS10410 2268731..2269315 - 585 WP_067474681.1 TetR/AcrR family transcriptional regulator -
BJL86_RS10415 2269476..2270330 + 855 WP_067474683.1 SDR family oxidoreductase -
BJL86_RS10420 2270704..2271129 - 426 WP_067474685.1 type II toxin-antitoxin system VapC family toxin Toxin
BJL86_RS10425 2271126..2271359 - 234 WP_067474687.1 Arc family DNA-binding protein Antitoxin
BJL86_RS10430 2271506..2272585 - 1080 WP_067474722.1 redox-regulated ATPase YchF -
BJL86_RS10435 2272925..2274295 + 1371 WP_082908513.1 AI-2E family transporter -
BJL86_RS10440 2274318..2275097 + 780 WP_067474691.1 hypothetical protein -
BJL86_RS10445 2275224..2275586 + 363 WP_067474693.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(2-122)

Antitoxin

Arc-like DNA binding domain

(12-41)


Sequences

Toxin        


Download         Length: 142 a.a.        Molecular weight: 15193.34 Da        Isoelectric Point: 4.5892

>T63994 WP_067474685.1 NZ_CP015961:c2271129-2270704 [Dietzia timorensis]
VIVLDTNVISEIFRPAPEPRVVDWLASLTGDVAITSVTLAELLAGVRRLADGRRRDELNTRIDAALEPYRGGRAVLPFDD
LAADRYADVLVSRENAGVPISTGVAQIAAICLSLGATCATRNVKDFVHTGVDLVDPWKINE

Download         Length: 426 bp

>T63994 NZ_CP015961:c2271129-2270704 [Dietzia timorensis]
GTGATTGTTCTCGACACGAACGTCATCTCAGAGATCTTCCGGCCCGCGCCGGAGCCACGCGTAGTGGACTGGCTCGCTTC
GCTGACGGGTGATGTCGCTATTACGTCCGTCACGCTCGCCGAGCTGCTCGCGGGTGTCCGGCGACTAGCGGATGGCCGAC
GCAGGGATGAGCTGAACACGCGCATTGACGCAGCGCTTGAGCCGTATCGCGGCGGTCGCGCCGTGCTGCCCTTCGACGAT
CTCGCGGCCGACCGCTATGCAGACGTGCTCGTGTCCCGAGAAAACGCGGGAGTACCGATCAGCACTGGCGTCGCGCAGAT
CGCCGCGATCTGCCTGTCCCTAGGTGCAACCTGTGCGACGCGGAACGTTAAGGACTTCGTGCACACCGGAGTCGACCTAG
TCGACCCATGGAAGATTAACGAGTGA

Antitoxin


Download         Length: 78 a.a.        Molecular weight: 8242.42 Da        Isoelectric Point: 5.0348

>AT63994 WP_067474687.1 NZ_CP015961:c2271359-2271126 [Dietzia timorensis]
MSSIVVRGLDDAVKQQLAAQAREHGRSMEAEVRAILTKAAQRPHIGIALLAAAQDLGGIEDLPVPVREDVARAVDFE

Download         Length: 234 bp

>AT63994 NZ_CP015961:c2271359-2271126 [Dietzia timorensis]
ATGTCATCCATTGTCGTTCGCGGGCTCGATGATGCCGTGAAGCAGCAGCTTGCCGCGCAGGCGAGAGAGCACGGCCGTTC
TATGGAAGCGGAGGTTCGCGCCATCCTGACGAAGGCCGCACAGAGGCCTCATATCGGAATCGCTCTGCTGGCTGCGGCGC
AAGACTTGGGCGGTATCGAAGATCTGCCGGTTCCGGTGCGAGAGGACGTCGCGCGGGCGGTTGACTTCGAGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A173LMN6

Antitoxin

Source ID Structure
AlphaFold DB A0A173LMJ7

References