Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) phd-doc/HTH_IclR(antitoxin)
Location 1393578..1395328 Replicon chromosome
Accession NZ_CP015959
Organism Paraburkholderia caribensis strain 852011

Toxin (Protein)


Gene name doc Uniprot ID -
Locus tag A9O66_RS22435 Protein ID WP_107202270.1
Coordinates 1394435..1395328 (-) Length 298 a.a.

Antitoxin (Protein)


Gene name phd Uniprot ID -
Locus tag A9O66_RS22430 Protein ID WP_107202304.1
Coordinates 1393578..1394438 (-) Length 287 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
A9O66_RS22410 1388777..1390273 - 1497 WP_107202269.1 aldehyde dehydrogenase -
A9O66_RS22415 1390298..1391128 - 831 WP_054933316.1 aspartate dehydrogenase -
A9O66_RS22420 1391121..1392779 - 1659 WP_054933315.1 thiamine pyrophosphate-binding protein -
A9O66_RS22425 1392772..1393578 - 807 WP_060604762.1 SDR family oxidoreductase -
A9O66_RS22430 1393578..1394438 - 861 WP_107202304.1 IclR family transcriptional regulator Antitoxin
A9O66_RS22435 1394435..1395328 - 894 WP_107202270.1 alpha/beta fold hydrolase Toxin
A9O66_RS22440 1395354..1395893 - 540 WP_035999007.1 cupin domain-containing protein -
A9O66_RS22445 1395929..1396687 - 759 WP_107202271.1 SDR family oxidoreductase -
A9O66_RS22450 1396680..1397768 - 1089 WP_107202272.1 aromatic ring-hydroxylating dioxygenase subunit alpha -
A9O66_RS22455 1397823..1398134 - 312 WP_035999001.1 hypothetical protein -
A9O66_RS22460 1398136..1398453 - 318 WP_035998998.1 non-heme iron oxygenase ferredoxin subunit -
A9O66_RS22465 1398895..1399968 + 1074 WP_107202273.1 porin -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Alpha/beta hydrolase fold-1

(50-276)

Antitoxin

Transcription regulator IclR, N-terminal

(26-74)


Sequences

Toxin        


Download         Length: 298 a.a.        Molecular weight: 31116.12 Da        Isoelectric Point: 6.2319

>T63992 WP_107202270.1 NZ_CP015959:c1395328-1394435 [Paraburkholderia caribensis]
MSAALPVTVDRTVTLETRLSHFPARRIAIAPQCAIGYREAGAGHADALPLVLLHGIGSGAASWVQQLEALGTTRRVFAWD
APGYGESTPVASASPKADEYAGALDAWLDALAVERCVLVGHSLGAIIAGSYAASRAQRVAGLLLISPAAGYGTASEDVRA
SKRDSRLAMLAELGPQGLADQRSANMLSPYADEASRDWVRWNMSRIVPTGYAQATHLLANADLASDVARVDGPIAVAVGA
EDSITPPSSCERIAQAARTRLQIIPRAGHAGYIEAANEYTALIDAFCRASDGQWSKA

Download         Length: 894 bp

>T63992 NZ_CP015959:c1395328-1394435 [Paraburkholderia caribensis]
ATGTCCGCAGCCTTGCCCGTCACTGTCGATCGAACCGTCACGCTGGAAACGCGCCTCTCGCACTTCCCGGCACGGCGGAT
CGCGATTGCGCCGCAATGCGCGATCGGCTATCGCGAAGCGGGTGCTGGGCACGCCGATGCGTTGCCGCTCGTGCTGTTGC
ACGGCATTGGTTCGGGCGCGGCTTCGTGGGTGCAACAACTCGAAGCGTTGGGCACGACGCGCCGCGTGTTCGCTTGGGAC
GCGCCGGGCTATGGCGAATCGACGCCCGTTGCATCGGCTTCGCCCAAGGCAGATGAATATGCTGGCGCGCTCGACGCATG
GCTCGATGCGCTCGCCGTAGAACGTTGCGTACTGGTCGGCCATTCGCTCGGCGCGATCATCGCGGGCTCGTACGCGGCAT
CGCGTGCGCAACGCGTCGCGGGGCTGTTGCTGATTTCGCCCGCGGCAGGCTACGGCACGGCATCCGAAGACGTGCGCGCG
TCGAAGCGCGACAGCCGTCTCGCGATGCTCGCCGAACTCGGCCCGCAAGGTCTCGCGGACCAACGCAGCGCCAACATGCT
GTCGCCGTACGCCGATGAAGCATCACGCGACTGGGTGCGCTGGAACATGTCGCGCATCGTGCCGACGGGTTACGCGCAGG
CGACGCATCTGCTCGCCAACGCGGATCTCGCCAGCGATGTCGCGAGGGTCGACGGCCCTATCGCCGTCGCGGTCGGGGCG
GAGGACTCGATCACCCCGCCGTCGTCATGCGAGCGGATTGCACAGGCGGCGCGCACGCGCCTGCAGATCATCCCGCGCGC
GGGTCACGCGGGCTACATCGAAGCGGCCAATGAATACACCGCGCTCATCGACGCATTCTGCCGCGCGAGCGACGGTCAAT
GGAGCAAAGCATGA

Antitoxin


Download         Length: 287 a.a.        Molecular weight: 31407.84 Da        Isoelectric Point: 6.5092

>AT63992 WP_107202304.1 NZ_CP015959:c1394438-1393578 [Paraburkholderia caribensis]
MTPELTGTAPEAEDDRNDAGYRVPGLERGLRILTEFSPREPVLGAPELSKRLGIPRTTVFRLLQTLESLGFLERADRDRN
YRLGVAVLRLGFEYLSSLELTDLGLPLIEALRDATGLTTHIVIRDGRDVVFVAKAQSHAPVFSSVKVNVGTRLPAHATTH
GHVLMGDLSLDELRALYPEKTLERFTKHTPATVDELYERVKDDAVRGFAISESSFENGISVISAPVRNDTGRIAAVITTT
IPRPQIDAALLDGGLIDKVRGAAEQLSLRLNYRPSAESRYMKALGL

Download         Length: 861 bp

>AT63992 NZ_CP015959:c1394438-1393578 [Paraburkholderia caribensis]
ATGACCCCCGAATTGACGGGCACTGCGCCTGAAGCAGAAGACGACCGCAACGACGCGGGCTATCGCGTGCCCGGACTCGA
ACGCGGCCTGCGCATTCTCACGGAGTTCTCGCCGCGCGAACCGGTGCTCGGCGCGCCCGAATTGTCGAAGCGCCTCGGCA
TTCCGCGCACGACGGTGTTCCGTCTGCTGCAGACGCTCGAATCACTGGGCTTTCTGGAGCGCGCGGATCGCGACCGCAAC
TATCGCCTGGGCGTCGCGGTGCTGCGCCTCGGCTTCGAATATCTCAGTTCGCTCGAACTTACCGATCTCGGCTTGCCGTT
GATCGAAGCTTTGCGCGACGCAACGGGGCTGACCACGCACATCGTGATCCGCGACGGCCGCGACGTGGTGTTCGTCGCGA
AGGCGCAGAGTCATGCGCCCGTGTTCAGTTCGGTGAAGGTCAACGTCGGCACGCGGCTACCCGCGCATGCGACTACGCAC
GGTCATGTGCTGATGGGCGATCTCTCGCTCGACGAACTGCGCGCGCTGTATCCGGAGAAGACGCTCGAACGCTTCACGAA
ACACACGCCCGCTACCGTCGACGAACTGTACGAGCGCGTGAAGGACGACGCGGTGCGCGGTTTCGCGATCAGCGAATCGT
CCTTCGAAAACGGTATCTCCGTCATCAGTGCGCCCGTGCGCAACGACACGGGCCGCATCGCCGCTGTCATCACCACCACC
ATTCCGCGCCCGCAGATCGACGCGGCGCTGCTCGACGGCGGCCTGATCGACAAGGTGCGCGGCGCGGCGGAGCAATTGTC
GCTGCGGCTGAACTACCGGCCGTCGGCGGAAAGCAGGTACATGAAGGCATTGGGGCTCTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References