Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/LOTUS_5_Limkain_b1-StbC
Location 445059..445719 Replicon chromosome
Accession NZ_CP015958
Organism Paraburkholderia caribensis strain 852011

Toxin (Protein)


Gene name vapC Uniprot ID -
Locus tag A9O66_RS01920 Protein ID WP_082434037.1
Coordinates 445059..445487 (-) Length 143 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID -
Locus tag A9O66_RS01925 Protein ID WP_035991398.1
Coordinates 445474..445719 (-) Length 82 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
A9O66_RS01900 441129..442085 - 957 WP_054934558.1 sugar ABC transporter substrate-binding protein -
A9O66_RS01905 442636..443274 + 639 WP_054934557.1 LysE family translocator -
A9O66_RS01910 443315..444292 - 978 WP_054934556.1 magnesium/cobalt transporter CorA -
A9O66_RS01915 444497..444970 - 474 WP_107200977.1 hypothetical protein -
A9O66_RS01920 445059..445487 - 429 WP_082434037.1 type II toxin-antitoxin system VapC family toxin Toxin
A9O66_RS01925 445474..445719 - 246 WP_035991398.1 DNA-binding protein Antitoxin
A9O66_RS01930 445889..446509 + 621 WP_107200976.1 ATP-binding protein -
A9O66_RS01935 446670..447767 - 1098 WP_107200975.1 saccharopine dehydrogenase NADP-binding domain-containing protein -
A9O66_RS01940 447975..448439 - 465 WP_035990996.1 Lrp/AsnC family transcriptional regulator -
A9O66_RS01945 448576..449460 - 885 WP_054934550.1 LysR family transcriptional regulator -
A9O66_RS01950 449613..450125 + 513 WP_035990992.1 Spy/CpxP family protein refolding chaperone -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(2-122)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 143 a.a.        Molecular weight: 15715.91 Da        Isoelectric Point: 7.4682

>T63990 WP_082434037.1 NZ_CP015958:c445487-445059 [Paraburkholderia caribensis]
VYLIDTNVISEMRKSSRANPGVQAFFETAKEGGHRLYLSVVTVGELRRGVDLIRHRGDKFQALRLEGWLDTIMNSFSSHI
LNVGTDVAQTWGHLRVPDPGHSLDKLIAATALIYNLTVVTRNVADFDGTGARVLNPFQLLDA

Download         Length: 429 bp

>T63990 NZ_CP015958:c445487-445059 [Paraburkholderia caribensis]
GTGTATTTGATTGATACCAATGTAATCAGCGAAATGCGCAAGAGCAGCCGCGCCAATCCGGGCGTACAGGCTTTTTTCGA
AACGGCGAAGGAAGGCGGGCATCGCCTGTATCTGTCTGTGGTGACGGTTGGCGAGTTGCGGCGCGGCGTCGACCTGATCC
GGCATCGGGGCGACAAGTTCCAGGCATTGCGCCTGGAAGGCTGGCTCGACACGATCATGAATTCGTTCAGCAGCCACATC
TTGAATGTCGGCACCGACGTTGCGCAGACGTGGGGCCATCTGCGCGTGCCCGACCCCGGGCATTCGCTGGACAAACTGAT
CGCGGCCACGGCCCTGATCTACAACCTGACTGTCGTGACGCGCAACGTGGCAGACTTCGATGGCACGGGCGCACGGGTGC
TCAATCCGTTCCAGCTTCTCGACGCATGA

Antitoxin


Download         Length: 82 a.a.        Molecular weight: 8938.90 Da        Isoelectric Point: 4.2208

>AT63990 WP_035991398.1 NZ_CP015958:c445719-445474 [Paraburkholderia caribensis]
MANLLVRNLDDALVQNLREQAAAHGRSVEAEHREILAQALFQPRKLSFAELLMSMPDVGDDADFERRNDATDDSGGPGVF
D

Download         Length: 246 bp

>AT63990 NZ_CP015958:c445719-445474 [Paraburkholderia caribensis]
ATGGCAAATCTTTTGGTCCGAAATCTGGACGATGCGTTGGTGCAGAACCTGCGTGAGCAGGCCGCGGCTCACGGGCGCAG
CGTCGAAGCAGAGCATCGGGAAATCCTGGCGCAGGCGCTCTTTCAGCCCAGGAAGCTCAGCTTCGCGGAATTGCTGATGA
GCATGCCCGACGTCGGCGACGACGCCGACTTCGAGCGCCGCAATGACGCAACTGACGATAGCGGGGGACCGGGTGTATTT
GATTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References