Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hicAB/HicA-HicB
Location 18673..19271 Replicon plasmid unnamed1
Accession NZ_CP015940
Organism Legionella pneumophila strain C8_S

Toxin (Protein)


Gene name hicA Uniprot ID Q5WRX3
Locus tag A9E84_RS15265 Protein ID WP_011212625.1
Coordinates 19074..19271 (-) Length 66 a.a.

Antitoxin (Protein)


Gene name hicB Uniprot ID Q5WRX4
Locus tag A9E84_RS15260 Protein ID WP_011212624.1
Coordinates 18673..19077 (-) Length 135 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
A9E84_RS15250 14813..17761 + 2949 WP_011212622.1 conjugative relaxase -
A9E84_RS15255 17778..18101 + 324 WP_011212623.1 hypothetical protein -
A9E84_RS15260 18673..19077 - 405 WP_011212624.1 type II toxin-antitoxin system HicB family antitoxin Antitoxin
A9E84_RS15265 19074..19271 - 198 WP_011212625.1 type II toxin-antitoxin system HicA family toxin Toxin
A9E84_RS15275 20143..21006 - 864 WP_011212627.1 DUF1738 domain-containing protein -
A9E84_RS16080 21315..21476 - 162 WP_011212628.1 hypothetical protein -
A9E84_RS15280 22049..22582 - 534 WP_011212629.1 hypothetical protein -
A9E84_RS15285 23849..24139 + 291 WP_041173942.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Non-Mobilizable plasmid - - 1..58092 58092


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HicA mRNA interferase family

(4-59)

Antitoxin

HicB-like antitoxin of toxin-antitoxin system

(3-126)


Sequences

Toxin        


Download         Length: 66 a.a.        Molecular weight: 7403.75 Da        Isoelectric Point: 10.6519

>T63962 WP_011212625.1 NZ_CP015940:c19271-19074 [Legionella pneumophila]
MKSAEIIKIIERDGWVQCHQKGSHCQFKHPTKKGRVTVPHPKKDLPIKTVASIFKQAGINKEDIK

Download         Length: 198 bp

>T63962 NZ_CP015940:c19271-19074 [Legionella pneumophila]
ATGAAAAGCGCAGAAATAATAAAAATAATTGAACGCGATGGTTGGGTGCAATGTCATCAGAAAGGAAGTCATTGCCAATT
TAAACATCCCACCAAAAAGGGTAGGGTGACAGTACCTCATCCTAAAAAAGATTTACCTATAAAAACAGTGGCCAGTATCT
TTAAACAAGCTGGTATTAATAAGGAGGATATAAAATGA

Antitoxin


Download         Length: 135 a.a.        Molecular weight: 15006.00 Da        Isoelectric Point: 4.5129

>AT63962 WP_011212624.1 NZ_CP015940:c19077-18673 [Legionella pneumophila]
MRYPVVIHKDEHSDFGVIVPDIPGCYSSGSTYDEALTNVIEAIECHLEGLLIDNEPLPVGTTIDRWINDEEFQGGVWAFV
DIDLSQISGKAKRINITMPERILSLIDLYAKNHAIKNRSSFLADAALSYMESHK

Download         Length: 405 bp

>AT63962 NZ_CP015940:c19077-18673 [Legionella pneumophila]
ATGAGATATCCTGTAGTAATACATAAAGACGAACATAGTGATTTTGGTGTAATTGTCCCTGATATTCCTGGATGCTATTC
TTCTGGTAGCACTTATGATGAAGCTTTAACTAACGTAATTGAGGCAATTGAATGCCATTTGGAAGGATTATTAATAGATA
ATGAGCCTCTTCCAGTTGGTACAACAATTGACCGATGGATTAATGATGAAGAGTTTCAGGGCGGGGTATGGGCATTTGTT
GACATTGATTTAAGCCAAATATCGGGTAAAGCAAAACGCATTAATATCACTATGCCAGAGCGCATTTTAAGCCTCATCGA
TCTGTATGCCAAAAACCATGCGATAAAAAATCGTTCCTCCTTTTTGGCCGATGCAGCTCTGAGTTATATGGAAAGTCATA
AGTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A3S0VJ23

Antitoxin

Source ID Structure
AlphaFold DB Q5WRX4

References