Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) yeeUV (cbtA-cbeA)/CbtA-CbeA
Location 4901863..4902698 Replicon chromosome
Accession NZ_CP015912
Organism Escherichia coli strain 210205630

Toxin (Protein)


Gene name yeeV Uniprot ID A0A6H2GFM1
Locus tag A9C00_RS24270 Protein ID WP_065304416.1
Coordinates 4902321..4902698 (+) Length 126 a.a.

Antitoxin (Protein)


Gene name yeeU Uniprot ID A0A6H2GGB7
Locus tag A9C00_RS24265 Protein ID WP_001285390.1
Coordinates 4901863..4902231 (+) Length 123 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
A9C00_RS24230 4897652..4898329 + 678 WP_059239983.1 hypothetical protein -
A9C00_RS24235 4898345..4898755 + 411 WP_000846713.1 hypothetical protein -
A9C00_RS24240 4898976..4899797 + 822 WP_065304414.1 DUF945 domain-containing protein -
A9C00_RS24245 4899888..4900373 + 486 WP_000214317.1 antirestriction protein -
A9C00_RS24250 4900388..4900864 + 477 WP_001186747.1 RadC family protein -
A9C00_RS24255 4900933..4901154 + 222 WP_000692312.1 DUF987 domain-containing protein -
A9C00_RS24260 4901169..4901813 + 645 WP_065304415.1 antitoxin of toxin-antitoxin stability system -
A9C00_RS24265 4901863..4902231 + 369 WP_001285390.1 type IV toxin-antitoxin system YeeU family antitoxin Antitoxin
A9C00_RS24270 4902321..4902698 + 378 WP_065304416.1 type IV toxin-antitoxin system toxin CbtA Toxin
A9C00_RS30495 4902695..4902874 + 180 Protein_4608 hypothetical protein -
A9C00_RS30500 4902920..4903117 + 198 WP_086598277.1 DUF957 domain-containing protein -
A9C00_RS24280 4903214..4904056 + 843 WP_065304417.1 DUF4942 domain-containing protein -
A9C00_RS24290 4904527..4905465 + 939 WP_000351317.1 glyoxylate/hydroxypyruvate reductase GhrA -
A9C00_RS24295 4905520..4906257 + 738 WP_065304418.1 zinc-binding phosphatase -
A9C00_RS24300 4906281..4906835 + 555 WP_001001902.1 molecular chaperone YcdY -
A9C00_RS24305 4906937..4907428 + 492 WP_001297187.1 DUF1097 domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

CbtA toxin of type IV toxin-antitoxin system

(1-112)

Antitoxin

Antitoxin CbeA

(18-117)


Sequences

Toxin        


Download         Length: 126 a.a.        Molecular weight: 14060.06 Da        Isoelectric Point: 7.8522

>T63919 WP_065304416.1 NZ_CP015912:4902321-4902698 [Escherichia coli]
MKTLPVLPGQAASSRPSPVEIWQTLLTRLLDQHYGLTLNDTPFADERVIEQHIEAGISLCDAVNFLVEKYALVRTDQPGF
SACTRSQLINSIDILRARRATGLMTRDNYRTVNNITLGKYQEAKQ

Download         Length: 378 bp

>T63919 NZ_CP015912:4902321-4902698 [Escherichia coli]
ATGAAAACATTACCTGTATTACCCGGGCAGGCGGCCAGTTCACGCCCGTCTCCGGTTGAAATCTGGCAGACACTGCTCAC
CCGACTGCTGGATCAGCACTACGGCCTTACGCTGAATGACACACCGTTCGCTGATGAACGTGTGATTGAGCAGCATATTG
AGGCAGGCATTTCACTGTGCGATGCGGTGAACTTTCTCGTTGAAAAATACGCACTGGTACGTACCGACCAGCCGGGATTC
AGCGCCTGTACCCGTTCTCAGTTAATAAACAGTATTGATATCCTCCGGGCACGCCGGGCAACCGGCCTGATGACACGCGA
CAACTACAGAACGGTAAATAACATTACCCTGGGTAAGTATCAGGAGGCGAAACAATGA

Antitoxin


Download         Length: 123 a.a.        Molecular weight: 13811.52 Da        Isoelectric Point: 5.9618

>AT63919 WP_001285390.1 NZ_CP015912:4901863-4902231 [Escherichia coli]
VSDTFHETNYPDDNNDRPWWGLPCTVTPCFGARLVQEGNRLHYLADRAGIRGRFSDADSYHLDQAFPLLMKQLELMLTSG
ELNPRHQHTVTLYAKGLTCEADTLGSCGYVYMAVYPTPETKK

Download         Length: 369 bp

>AT63919 NZ_CP015912:4901863-4902231 [Escherichia coli]
GTGTCAGACACGTTCCATGAAACAAATTATCCCGACGACAACAACGACCGCCCCTGGTGGGGGCTACCCTGCACCGTGAC
GCCCTGTTTTGGTGCCCGTCTGGTACAGGAAGGCAACCGGTTGCATTACCTTGCCGACCGCGCCGGTATCAGAGGGCGGT
TCAGCGACGCGGATTCGTACCACCTGGACCAGGCCTTTCCGCTGCTGATGAAACAACTGGAGCTCATGCTCACCAGCGGT
GAACTGAATCCCCGCCATCAACATACCGTCACGCTGTATGCAAAAGGGCTGACCTGCGAAGCCGATACCCTCGGCAGTTG
TGGCTACGTTTATATGGCTGTTTATCCGACGCCCGAAACGAAAAAGTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A6H2GFM1

Antitoxin

Source ID Structure
AlphaFold DB A0A6H2GGB7

References