Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/VapC-StbC
Location 805432..806087 Replicon chromosome
Accession NZ_CP015886
Organism Neisseria meningitidis strain 38277

Toxin (Protein)


Gene name vapC Uniprot ID -
Locus tag AT729_RS04585 Protein ID WP_079889442.1
Coordinates 805668..806087 (+) Length 140 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID -
Locus tag AT729_RS04580 Protein ID WP_079889441.1
Coordinates 805432..805668 (+) Length 79 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
AT729_RS04535 800498..801280 + 783 WP_079889437.1 hypothetical protein -
AT729_RS04540 801871..802065 + 195 WP_079889438.1 hypothetical protein -
AT729_RS04545 802022..802252 + 231 WP_079889439.1 type II toxin-antitoxin system RelE/ParE family toxin -
AT729_RS04550 802314..803321 + 1008 WP_079889368.1 IS5 family transposase -
AT729_RS04565 803925..804119 + 195 WP_021439529.1 DUF5397 domain-containing protein -
AT729_RS04570 804119..804397 + 279 WP_021439528.1 endoribonuclease VapD -
AT729_RS04575 804492..804890 - 399 WP_079889440.1 hypothetical protein -
AT729_RS04580 805432..805668 + 237 WP_079889441.1 type II toxin-antitoxin system antitoxin FitA Antitoxin
AT729_RS04585 805668..806087 + 420 WP_079889442.1 type II toxin-antitoxin system VapC family toxin Toxin
AT729_RS04590 806151..806603 - 453 WP_079889443.1 hypothetical protein -
AT729_RS04595 806696..807736 - 1041 WP_079889444.1 traS protein -
AT729_RS04600 807733..808248 - 516 WP_096100408.1 plasmid mobilization relaxosome protein MobC -
AT729_RS04605 808343..810328 - 1986 Protein_749 toprim domain protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Integrative and Conjugative Element - - 792850..827905 35055
- flank IS/Tn - - 802314..803321 1007


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(2-124)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 140 a.a.        Molecular weight: 15292.66 Da        Isoelectric Point: 5.6327

>T63888 WP_079889442.1 NZ_CP015886:805668-806087 [Neisseria meningitidis]
MILLDTNVISEPLRPQPTERVVAWLDSLILEDVYLSAITVAELRLGVALLPDGKKKNVLHERLEQSILPLFAGQILPFDE
PVATIYAQIRSYAKTHGKAIAAADGYIAATAKQHRLTVATRDTGPFFAADVAVFNPWQD

Download         Length: 420 bp

>T63888 NZ_CP015886:805668-806087 [Neisseria meningitidis]
ATGATTTTGCTGGACACGAATGTGATTTCTGAACCTTTGCGCCCACAACCCACTGAACGTGTGGTGGCATGGTTAGATAG
TTTGATATTGGAAGATGTTTATTTGTCTGCCATTACTGTTGCAGAATTGCGTTTGGGTGTGGCGTTGTTGCCCGACGGCA
AGAAAAAGAATGTGCTGCACGAACGTTTGGAGCAATCCATTTTGCCTTTATTTGCGGGGCAAATTTTGCCTTTTGATGAA
CCGGTTGCCACAATATATGCGCAAATTCGTTCCTATGCCAAAACACATGGCAAAGCGATTGCTGCCGCAGACGGCTATAT
TGCTGCCACCGCAAAACAGCACCGGTTAACAGTTGCTACGCGTGATACCGGCCCATTTTTTGCGGCTGATGTCGCAGTAT
TCAATCCGTGGCAAGATTAA

Antitoxin


Download         Length: 79 a.a.        Molecular weight: 8549.68 Da        Isoelectric Point: 5.8257

>AT63888 WP_079889441.1 NZ_CP015886:805432-805668 [Neisseria meningitidis]
MASVVIRNLSETTHNAIKFRARAAGRSTEAEIRLILDNIAKAQQTVRLGSMLASIGQEIGGVELEDVRERNTENEVSL

Download         Length: 237 bp

>AT63888 NZ_CP015886:805432-805668 [Neisseria meningitidis]
ATGGCTTCTGTTGTGATTAGAAATTTATCCGAGACCACGCACAACGCAATCAAATTCCGTGCGCGAGCCGCAGGGCGTAG
TACCGAAGCAGAAATCCGCTTAATTTTGGATAACATCGCCAAAGCGCAACAAACCGTACGTTTGGGGTCAATGTTGGCAT
CAATCGGGCAAGAAATCGGCGGTGTTGAGTTGGAAGACGTACGCGAGCGCAATACCGAGAACGAGGTTTCTTTGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References