Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) VapXD/-
Location 803925..804397 Replicon chromosome
Accession NZ_CP015886
Organism Neisseria meningitidis strain 38277

Toxin (Protein)


Gene name VapD Uniprot ID A0A424FH90
Locus tag AT729_RS04570 Protein ID WP_021439528.1
Coordinates 804119..804397 (+) Length 93 a.a.

Antitoxin (Protein)


Gene name VapX Uniprot ID A0A425B3V8
Locus tag AT729_RS04565 Protein ID WP_021439529.1
Coordinates 803925..804119 (+) Length 65 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
AT729_RS13260 799256..799423 + 168 WP_154021989.1 hypothetical protein -
AT729_RS04525 799548..800210 - 663 WP_079889436.1 helix-turn-helix domain-containing protein -
AT729_RS04530 800314..800493 + 180 WP_002244220.1 regulatory protein cro -
AT729_RS04535 800498..801280 + 783 WP_079889437.1 hypothetical protein -
AT729_RS04540 801871..802065 + 195 WP_079889438.1 hypothetical protein -
AT729_RS04545 802022..802252 + 231 WP_079889439.1 type II toxin-antitoxin system RelE/ParE family toxin -
AT729_RS04550 802314..803321 + 1008 WP_079889368.1 IS5 family transposase -
AT729_RS04565 803925..804119 + 195 WP_021439529.1 DUF5397 domain-containing protein Antitoxin
AT729_RS04570 804119..804397 + 279 WP_021439528.1 endoribonuclease VapD Toxin
AT729_RS04575 804492..804890 - 399 WP_079889440.1 hypothetical protein -
AT729_RS04580 805432..805668 + 237 WP_079889441.1 type II toxin-antitoxin system antitoxin FitA -
AT729_RS04585 805668..806087 + 420 WP_079889442.1 type II toxin-antitoxin system VapC family toxin -
AT729_RS04590 806151..806603 - 453 WP_079889443.1 hypothetical protein -
AT729_RS04595 806696..807736 - 1041 WP_079889444.1 traS protein -
AT729_RS04600 807733..808248 - 516 WP_096100408.1 plasmid mobilization relaxosome protein MobC -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Integrative and Conjugative Element - - 792850..827905 35055
- flank IS/Tn - - 802314..803321 1007


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Virulence-associated protein D / CRISPR associated protein Cas2

(1-86)

Antitoxin

Protein of unknown function DUF5397

(1-63)


Sequences

Toxin        


Download         Length: 93 a.a.        Molecular weight: 10459.86 Da        Isoelectric Point: 6.9726

>T63887 WP_021439528.1 NZ_CP015886:804119-804397 [Neisseria meningitidis]
MYAISFDLVVADTAQNHPKGISQAYADIGYTLRKFGFTRVQGSLYTCQNEDMANLFSAINELKALPWFPSSVRDIRAFRI
EQWSDFTSLVKS

Download         Length: 279 bp

>T63887 NZ_CP015886:804119-804397 [Neisseria meningitidis]
ATGTACGCGATTTCTTTTGATTTGGTGGTTGCCGATACCGCTCAAAACCATCCGAAAGGCATTTCCCAAGCCTACGCAGA
TATTGGATACACCTTGCGGAAATTCGGCTTTACCCGCGTTCAGGGAAGTTTGTACACCTGCCAAAACGAAGACATGGCTA
ACCTGTTTTCAGCCATCAACGAGCTAAAAGCTCTGCCTTGGTTTCCGTCTTCCGTCCGCGATATTCGGGCGTTCCGCATT
GAGCAGTGGTCTGATTTCACAAGTCTTGTGAAGTCTTAA

Antitoxin


Download         Length: 65 a.a.        Molecular weight: 7003.83 Da        Isoelectric Point: 4.2641

>AT63887 WP_021439529.1 NZ_CP015886:803925-804119 [Neisseria meningitidis]
MQTTANTIPTGSIRTFGDYGVMYIVGTPAEQLPDGDWLVNIELPESGEHTQYKLSHIVQDPKAA

Download         Length: 195 bp

>AT63887 NZ_CP015886:803925-804119 [Neisseria meningitidis]
ATGCAGACCACAGCAAATACCATCCCCACCGGTTCAATCCGCACCTTTGGCGATTACGGCGTGATGTACATCGTCGGCAC
GCCTGCCGAACAGCTTCCTGACGGCGATTGGCTCGTAAATATCGAGCTGCCGGAAAGCGGCGAACACACGCAATACAAAC
TGTCCCACATCGTTCAAGACCCAAAGGCTGCCTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A424FH90

Antitoxin

Source ID Structure
AlphaFold DB A0A425B3V8

References