Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relE-dinJ/YafQ-DinJ
Location 34295..34829 Replicon plasmid Efsorialis-p2
Accession NZ_CP015885
Organism Enterococcus faecalis strain sorialis

Toxin (Protein)


Gene name relE Uniprot ID R3JX52
Locus tag A6B47_RS15145 Protein ID WP_002360769.1
Coordinates 34554..34829 (+) Length 92 a.a.

Antitoxin (Protein)


Gene name dinJ Uniprot ID R3H6P0
Locus tag A6B47_RS15140 Protein ID WP_002369771.1
Coordinates 34295..34561 (+) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
A6B47_RS15105 30162..30947 + 786 WP_000803546.1 replication-relaxation family protein -
A6B47_RS15110 30953..31441 + 489 WP_024041577.1 hypothetical protein -
A6B47_RS15115 32033..32299 + 267 WP_002365974.1 hypothetical protein -
A6B47_RS15120 32332..32826 + 495 WP_010822509.1 DnaJ domain-containing protein -
A6B47_RS15125 32923..33339 + 417 WP_002368093.1 single-stranded DNA-binding protein -
A6B47_RS15130 33363..33947 + 585 WP_087548825.1 thermonuclease family protein -
A6B47_RS15135 33944..34192 + 249 WP_002369773.1 hypothetical protein -
A6B47_RS15140 34295..34561 + 267 WP_002369771.1 type II toxin-antitoxin system RelB/DinJ family antitoxin Antitoxin
A6B47_RS15145 34554..34829 + 276 WP_002360769.1 type II toxin-antitoxin system YafQ family toxin Toxin
A6B47_RS15155 35632..35817 + 186 WP_002365983.1 hypothetical protein -
A6B47_RS15160 35802..35993 + 192 WP_033790713.1 DpnD/PcfM family protein -
A6B47_RS15165 36224..37003 + 780 WP_024041581.1 PcfK -
A6B47_RS15170 37003..38262 + 1260 WP_024041582.1 PcfJ domain-containing protein -
A6B47_RS15180 38912..39640 + 729 WP_033624755.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Non-Mobilizable plasmid - prgB/asc10 1..55548 55548


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, YafQ-like toxin

(3-91)

Antitoxin

RelB antitoxin/Antitoxin DinJ

(7-87)


Sequences

Toxin        


Download         Length: 92 a.a.        Molecular weight: 10732.58 Da        Isoelectric Point: 9.6918

>T63882 WP_002360769.1 NZ_CP015885:34554-34829 [Enterococcus faecalis]
MLEIFYTNQFKKDFKKAKKQGKNLEKLKEVLVLLQEQQTLPPKYKDHALTGNYIGTRECHIEPDWLLIYKIDGDKLILTL
ARIGSHSELFR

Download         Length: 276 bp

>T63882 NZ_CP015885:34554-34829 [Enterococcus faecalis]
ATGCTTGAAATATTTTACACGAACCAATTCAAAAAAGACTTTAAGAAAGCAAAGAAACAAGGAAAGAATTTAGAGAAGTT
AAAAGAAGTATTAGTACTTTTACAAGAACAGCAAACATTGCCGCCAAAGTATAAAGACCACGCATTAACAGGAAATTATA
TAGGTACAAGAGAGTGCCATATTGAACCAGATTGGTTACTGATTTATAAAATTGACGGTGATAAATTGATCCTAACTTTA
GCTCGAATAGGCTCACATAGTGAATTATTTCGATGA

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 9804.15 Da        Isoelectric Point: 4.4791

>AT63882 WP_002369771.1 NZ_CP015885:34295-34561 [Enterococcus faecalis]
MATTKKKPIHVNVDENLKEEAEQLFDDLGLNMTSAITIFLKQSINEQAIPFMINKGNKETLQALKDIKEGNVHGGFSSVE
DLMEDLNA

Download         Length: 267 bp

>AT63882 NZ_CP015885:34295-34561 [Enterococcus faecalis]
TTGGCTACTACAAAAAAGAAACCTATACATGTAAATGTTGATGAAAATTTAAAAGAAGAAGCAGAACAATTATTTGATGA
TTTAGGGTTAAATATGACAAGTGCAATTACTATTTTCTTAAAACAGTCTATTAATGAGCAAGCAATTCCTTTTATGATTA
ATAAGGGAAACAAAGAGACTCTACAAGCATTAAAAGACATTAAAGAAGGAAACGTTCATGGTGGATTTTCTTCCGTGGAG
GATTTAATGGAGGATTTAAATGCTTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0M2AEA7

Antitoxin

Source ID Structure
AlphaFold DB A0A0M2AED7

References