Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/LOTUS_5_Limkain_b1(toxin)
Location 6412920..6413494 Replicon chromosome
Accession NZ_CP015878
Organism Pseudomonas citronellolis strain SJTE-3

Toxin (Protein)


Gene name vapC Uniprot ID A0A1A9KJA0
Locus tag A9C11_RS28040 Protein ID WP_064584506.1
Coordinates 6412920..6413285 (-) Length 122 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID W5ISP5
Locus tag A9C11_RS28045 Protein ID WP_009613188.1
Coordinates 6413279..6413494 (-) Length 72 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
A9C11_RS28020 6408464..6410875 + 2412 WP_064584498.1 TonB-dependent receptor -
A9C11_RS28025 6410883..6412031 + 1149 WP_064584501.1 PepSY domain-containing protein -
A9C11_RS28030 6412028..6412210 + 183 WP_058073002.1 hypothetical protein -
A9C11_RS28035 6412207..6412932 + 726 WP_064584502.1 hypothetical protein -
A9C11_RS28040 6412920..6413285 - 366 WP_064584506.1 type II toxin-antitoxin system VapC family toxin Toxin
A9C11_RS28045 6413279..6413494 - 216 WP_009613188.1 ribbon-helix-helix domain-containing protein Antitoxin
A9C11_RS28050 6413563..6415587 - 2025 WP_064584509.1 oligopeptide transporter, OPT family -
A9C11_RS28055 6415776..6416612 - 837 WP_064584511.1 taurine dioxygenase -
A9C11_RS28060 6416800..6417618 - 819 WP_009613191.1 ABC transporter permease subunit -
A9C11_RS28065 6417608..6418399 - 792 WP_043318713.1 ATP-binding cassette domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(5-106)

Antitoxin

Ribbon-helix-helix protein, CopG

(5-40)


Sequences

Toxin        


Download         Length: 122 a.a.        Molecular weight: 13404.51 Da        Isoelectric Point: 5.8683

>T63847 WP_064584506.1 NZ_CP015878:c6413285-6412920 [Pseudomonas citronellolis]
MVKALFDTNILIDYLNGHEQARDELRRYDDPAISIVTWMEVMIGATPATAAATRAFLDSFALVPLDAPVAERAVAVRQAL
RVKLPDAIIKASAEVQGRLLVTRNTREFPVDDAGVRLPYRL

Download         Length: 366 bp

>T63847 NZ_CP015878:c6413285-6412920 [Pseudomonas citronellolis]
ATGGTGAAGGCGCTGTTCGACACCAACATCCTCATCGACTACCTCAACGGCCACGAACAGGCCCGCGACGAGTTGCGCCG
CTACGATGACCCCGCCATCAGCATCGTCACCTGGATGGAGGTGATGATCGGCGCCACGCCCGCCACCGCCGCGGCCACCC
GCGCCTTCCTCGACAGCTTCGCCCTGGTGCCGCTCGACGCGCCCGTCGCCGAGCGCGCCGTGGCGGTGCGCCAGGCGTTG
CGGGTGAAGCTGCCGGACGCCATCATCAAGGCCAGCGCCGAGGTGCAGGGGCGCCTGCTGGTCACCCGCAACACCAGGGA
GTTCCCCGTCGACGACGCCGGCGTGCGCCTGCCCTACCGGCTCTGA

Antitoxin


Download         Length: 72 a.a.        Molecular weight: 8033.94 Da        Isoelectric Point: 4.7616

>AT63847 WP_009613188.1 NZ_CP015878:c6413494-6413279 [Pseudomonas citronellolis]
MRTLVDIPAEHLEALNALGEQQQQSRAALIREAVAEYLVRHRRQDAEAAFGLWNGSAGDGLAYQEKVREEW

Download         Length: 216 bp

>AT63847 NZ_CP015878:c6413494-6413279 [Pseudomonas citronellolis]
ATGCGTACCCTGGTCGACATCCCTGCCGAACATCTCGAAGCGCTCAATGCCCTGGGCGAGCAACAGCAGCAATCGCGCGC
CGCGCTGATCCGCGAGGCGGTCGCCGAGTACCTGGTCCGGCACCGCCGGCAGGATGCCGAGGCCGCCTTCGGCCTGTGGA
ACGGCAGCGCCGGCGACGGCCTGGCCTACCAAGAGAAGGTGCGCGAGGAATGGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A1A9KJA0

Antitoxin

Source ID Structure
AlphaFold DB A0A1A5D6Z2

References