Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/VapC-VagC
Location 6390004..6390671 Replicon chromosome
Accession NZ_CP015878
Organism Pseudomonas citronellolis strain SJTE-3

Toxin (Protein)


Gene name VapC1 Uniprot ID A0A1A9KJC7
Locus tag A9C11_RS27945 Protein ID WP_064584476.1
Coordinates 6390261..6390671 (+) Length 137 a.a.

Antitoxin (Protein)


Gene name VapB1 Uniprot ID W5ISS6
Locus tag A9C11_RS27940 Protein ID WP_009613156.1
Coordinates 6390004..6390264 (+) Length 87 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
A9C11_RS27915 6385286..6385528 - 243 WP_009613144.1 YdcH family protein -
A9C11_RS27920 6385719..6386132 + 414 WP_064584474.1 large-conductance mechanosensitive channel protein MscL -
A9C11_RS27925 6386150..6387703 - 1554 WP_064584475.1 TerC family protein -
A9C11_RS27930 6387892..6388668 - 777 WP_058488324.1 ferredoxin--NADP reductase -
A9C11_RS27935 6388797..6389921 + 1125 WP_064585156.1 class I SAM-dependent methyltransferase -
A9C11_RS27940 6390004..6390264 + 261 WP_009613156.1 AbrB/MazE/SpoVT family DNA-binding domain-containing protein Antitoxin
A9C11_RS27945 6390261..6390671 + 411 WP_064584476.1 type II toxin-antitoxin system VapC family toxin Toxin
A9C11_RS27950 6391229..6391789 - 561 WP_064584477.1 nucleotidyltransferase family protein -
A9C11_RS27955 6391786..6392754 - 969 WP_064584479.1 XdhC family protein -
A9C11_RS27960 6392756..6393991 - 1236 WP_064584481.1 cytochrome c -
A9C11_RS27965 6393994..6394527 - 534 WP_064584484.1 (2Fe-2S)-binding protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(3-127)

Antitoxin

SpoVT-AbrB domain

(11-49)


Sequences

Toxin        


Download         Length: 137 a.a.        Molecular weight: 15447.75 Da        Isoelectric Point: 6.7066

>T63846 WP_064584476.1 NZ_CP015878:6390261-6390671 [Pseudomonas citronellolis]
VKYLLDTNILIYLLKNRPESVARRVNALPADAGLCMSFFTYAELLKGAERSTRRSEILRQLERLTRQVPVVYDGTPRLCE
HYATQFTRLKLAGTPIGANDLWIACHALALEATLVTHDTREFERIDGLSLEDWAAE

Download         Length: 411 bp

>T63846 NZ_CP015878:6390261-6390671 [Pseudomonas citronellolis]
GTGAAATACCTGCTCGACACCAACATCCTCATCTACCTGCTGAAGAACCGCCCGGAATCCGTGGCCCGACGGGTCAACGC
CCTGCCCGCCGACGCCGGCCTGTGCATGTCCTTCTTCACCTACGCCGAGCTGCTCAAGGGCGCCGAACGCAGCACCCGGC
GCAGCGAGATCCTGCGCCAGCTGGAGCGCCTGACGCGCCAGGTGCCGGTGGTCTACGACGGCACTCCGCGCCTGTGCGAG
CACTACGCGACGCAGTTCACCCGGCTGAAGCTGGCCGGGACGCCGATCGGCGCCAACGACCTGTGGATCGCCTGTCACGC
CCTGGCGCTGGAGGCGACCCTGGTGACGCACGACACCCGCGAGTTCGAACGCATCGACGGGCTGAGCCTGGAAGATTGGG
CGGCCGAGTAG

Antitoxin


Download         Length: 87 a.a.        Molecular weight: 9789.91 Da        Isoelectric Point: 4.2182

>AT63846 WP_009613156.1 NZ_CP015878:6390004-6390264 [Pseudomonas citronellolis]
MSSPTLPSRVFMNGNSQAVRIPQEFRLDASRVEIRRQANGDLVIHPLPEDRGEALLQALSGFDDEFIEALEEGQREQPPM
QEREEL

Download         Length: 261 bp

>AT63846 NZ_CP015878:6390004-6390264 [Pseudomonas citronellolis]
ATGTCTTCGCCCACACTTCCCAGCCGCGTCTTCATGAACGGCAACAGCCAGGCGGTGCGCATTCCCCAGGAGTTCCGCCT
GGACGCCAGCCGCGTGGAAATCCGCCGCCAGGCCAATGGCGACCTGGTCATCCACCCATTGCCCGAGGACCGCGGCGAGG
CGTTGCTGCAGGCGCTGTCCGGCTTCGACGACGAGTTCATCGAAGCACTGGAGGAAGGGCAGCGCGAACAGCCGCCGATG
CAGGAGCGGGAAGAGCTGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A1A9KJC7

Antitoxin

Source ID Structure
AlphaFold DB A0A1A5D6X2

References