Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) /Xre(antitoxin)
Location 5283988..5285127 Replicon chromosome
Accession NZ_CP015878
Organism Pseudomonas citronellolis strain SJTE-3

Toxin (Protein)


Gene name - Uniprot ID A0A1A9KFP9
Locus tag A9C11_RS22865 Protein ID WP_009620578.1
Coordinates 5283988..5284758 (-) Length 257 a.a.

Antitoxin (Protein)


Gene name - Uniprot ID A0A1A5D9R9
Locus tag A9C11_RS22870 Protein ID WP_043271094.1
Coordinates 5284759..5285127 (-) Length 123 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
A9C11_RS22850 5280657..5281544 + 888 WP_064583927.1 metal-dependent hydrolase -
A9C11_RS22855 5281817..5283181 - 1365 WP_099049127.1 DNA recombination protein RmuC -
A9C11_RS22860 5283706..5283912 - 207 WP_064583929.1 hypothetical protein -
A9C11_RS22865 5283988..5284758 - 771 WP_009620578.1 RES family NAD+ phosphorylase Toxin
A9C11_RS22870 5284759..5285127 - 369 WP_043271094.1 DUF2384 domain-containing protein Antitoxin
A9C11_RS22875 5285406..5285840 + 435 WP_024128552.1 RcnB family protein -
A9C11_RS22880 5285847..5286278 - 432 WP_064583930.1 hypothetical protein -
A9C11_RS22885 5286407..5286889 + 483 WP_064583931.1 GreA/GreB family elongation factor -
A9C11_RS22890 5286961..5287302 + 342 WP_009620588.1 carboxymuconolactone decarboxylase family protein -
A9C11_RS22895 5287394..5287765 + 372 WP_064583932.1 hypothetical protein -
A9C11_RS22900 5287753..5288802 - 1050 WP_064583933.1 diguanylate cyclase -
A9C11_RS22905 5289096..5289932 + 837 Protein_4636 acid phosphatase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

RES domain

(69-212)

Antitoxin

Antitoxin Xre/MbcA/ParS-like, toxin-binding domain

(71-120)


Sequences

Toxin        


Download         Length: 257 a.a.        Molecular weight: 28862.03 Da        Isoelectric Point: 7.0428

>T63845 WP_009620578.1 NZ_CP015878:c5284758-5283988 [Pseudomonas citronellolis]
MALDAGAELWRECRGEQAIAPLRGKLVRLVESQEQVATLQLVDTLEEQALLEELIETSKPHLPPSTETLHYLLKTPFRYP
PLRWGSRFGRRHEPSLFYAALRLETAMAEAAYYRFVLWEGMASPPPSGRILSEHASFEARFQVQRGIRLQAPPFDSYAER
LQDPRDYRLTQALGSAMRAAAVEAFEYRSARCPEGGLNAALFVPSAFVDKRPRNLMPWLCETTADYVAFKHAQVPGAPRL
FPRAGFLVEGDLPHPA

Download         Length: 771 bp

>T63845 NZ_CP015878:c5284758-5283988 [Pseudomonas citronellolis]
ATGGCCCTCGACGCCGGCGCCGAACTGTGGCGCGAATGCCGGGGCGAGCAGGCCATCGCCCCGCTGCGGGGCAAGCTGGT
GCGCCTGGTGGAGAGCCAGGAGCAGGTCGCGACCCTGCAACTGGTGGATACCCTGGAGGAGCAGGCCCTGCTGGAAGAGC
TGATCGAGACCAGCAAGCCGCACCTGCCGCCGTCCACCGAAACCCTGCACTACCTGCTCAAGACGCCGTTCCGCTACCCG
CCGCTGCGCTGGGGCTCGCGCTTCGGCCGCCGCCACGAACCCAGCCTGTTCTACGCCGCGTTGCGCCTGGAGACGGCCAT
GGCCGAGGCGGCCTATTACCGCTTCGTGCTCTGGGAGGGCATGGCCAGCCCGCCGCCCAGCGGGCGCATCCTTTCCGAGC
ACGCTTCTTTCGAGGCGCGTTTCCAGGTGCAACGGGGCATACGCCTGCAGGCGCCGCCCTTCGACAGCTATGCCGAGCGC
CTGCAGGACCCGCGGGACTACCGCCTGACCCAGGCGCTGGGCAGCGCGATGCGCGCTGCCGCGGTGGAGGCCTTCGAATA
CCGCTCGGCGCGCTGCCCGGAAGGTGGGCTGAATGCCGCGCTCTTCGTGCCTTCGGCCTTCGTCGACAAGCGCCCGCGCA
ACCTCATGCCCTGGCTGTGCGAGACCACCGCCGACTACGTGGCCTTCAAGCATGCCCAGGTGCCGGGGGCGCCGCGGCTG
TTCCCGCGCGCGGGATTCCTGGTCGAGGGCGACCTGCCGCACCCGGCGTGA

Antitoxin


Download         Length: 123 a.a.        Molecular weight: 13395.70 Da        Isoelectric Point: 10.8284

>AT63845 WP_043271094.1 NZ_CP015878:c5285127-5284759 [Pseudomonas citronellolis]
MSALIRETPSADLVLAKAVLAAREQLGMTQQELAAIVGVDRSAVSRWKSGGLRVGSKTGELALLLVRVYRALFALFGGNL
EDMRHFLRTPNRHLSGVPLQRMEQVQGLVQVVEYLDAIRGKI

Download         Length: 369 bp

>AT63845 NZ_CP015878:c5285127-5284759 [Pseudomonas citronellolis]
ATGAGCGCACTGATCCGGGAAACTCCGTCGGCCGATCTGGTCCTGGCCAAGGCGGTACTGGCTGCCCGTGAGCAACTGGG
CATGACGCAGCAGGAGCTGGCCGCCATCGTCGGCGTCGATCGCAGCGCGGTGAGCCGCTGGAAGAGCGGTGGCCTGCGGG
TGGGCAGCAAGACCGGAGAACTGGCGCTGCTGCTGGTGCGGGTGTACCGCGCGCTCTTCGCCCTGTTCGGCGGCAACCTG
GAGGACATGCGTCACTTCCTGCGCACCCCCAACCGCCACCTGAGCGGGGTGCCGCTGCAGCGGATGGAGCAGGTGCAGGG
CCTGGTGCAGGTGGTCGAGTACCTCGACGCCATCCGGGGCAAGATCTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A1A9KFP9

Antitoxin

Source ID Structure
AlphaFold DB A0A1A5D9R9

References