Detailed information of TA system
Bioinformatically predictedOverview
TA module
Type | II | Classification (family/domain) | hicAB/HicA(toxin) |
Location | 1157772..1158361 | Replicon | chromosome |
Accession | NZ_CP015878 | ||
Organism | Pseudomonas citronellolis strain SJTE-3 |
Toxin (Protein)
Gene name | hicA | Uniprot ID | A0A1A9K8U9 |
Locus tag | A9C11_RS05150 | Protein ID | WP_064581993.1 |
Coordinates | 1157772..1158023 (+) | Length | 84 a.a. |
Antitoxin (Protein)
Gene name | hicB | Uniprot ID | A0A1A9K798 |
Locus tag | A9C11_RS05155 | Protein ID | WP_064581994.1 |
Coordinates | 1158020..1158361 (+) | Length | 114 a.a. |
Genomic Context
Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
---|---|---|---|---|---|---|
A9C11_RS33925 | 1154165..1155184 | - | 1020 | WP_082936681.1 | UDP-glucose 4-epimerase GalE | - |
A9C11_RS05140 | 1155628..1156344 | + | 717 | WP_082936682.1 | glycosyltransferase family 25 protein | - |
A9C11_RS05145 | 1156446..1157525 | + | 1080 | WP_167543638.1 | diguanylate cyclase | - |
A9C11_RS35210 | 1157522..1157668 | - | 147 | WP_208858253.1 | hypothetical protein | - |
A9C11_RS05150 | 1157772..1158023 | + | 252 | WP_064581993.1 | type II toxin-antitoxin system HicA family toxin | Toxin |
A9C11_RS05155 | 1158020..1158361 | + | 342 | WP_064581994.1 | type II toxin-antitoxin system HicB family antitoxin | Antitoxin |
A9C11_RS05160 | 1158427..1158654 | + | 228 | WP_064581996.1 | DUF433 domain-containing protein | - |
A9C11_RS05165 | 1158843..1160039 | - | 1197 | WP_064581998.1 | type II toxin-antitoxin system HipA family toxin | - |
A9C11_RS05170 | 1160039..1160290 | - | 252 | WP_043272292.1 | helix-turn-helix domain-containing protein | - |
A9C11_RS05175 | 1160587..1161435 | - | 849 | WP_061560729.1 | carboxylating nicotinate-nucleotide diphosphorylase | - |
Associated MGEs
MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
---|---|---|---|---|---|---|---|
- | inside | Genomic island | - | xcpA/pilD / pilC / pilB | 1144629..1160290 | 15661 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 84 a.a. Molecular weight: 9520.03 Da Isoelectric Point: 10.0940
>T63839 WP_064581993.1 NZ_CP015878:1157772-1158023 [Pseudomonas citronellolis]
MSRNEKLLAKLLNESASFTWQELVTLLRWLGYRQLEGSGSRVKFDNGDPLALINLHKPHPGNELKAYVRRQIIEHLKAGE
LIP
MSRNEKLLAKLLNESASFTWQELVTLLRWLGYRQLEGSGSRVKFDNGDPLALINLHKPHPGNELKAYVRRQIIEHLKAGE
LIP
Download Length: 252 bp
>T63839 NZ_CP015878:1157772-1158023 [Pseudomonas citronellolis]
ATGTCCAGGAACGAGAAACTGCTGGCCAAGCTACTCAACGAAAGCGCCAGCTTTACCTGGCAGGAGCTTGTGACACTGCT
GCGTTGGCTGGGCTACAGGCAGTTGGAGGGCAGCGGGAGCCGGGTCAAGTTCGACAACGGCGACCCGCTGGCGTTGATCA
ACCTTCACAAGCCGCACCCGGGCAACGAGCTGAAAGCCTATGTCCGGCGCCAGATCATCGAGCACCTCAAGGCGGGGGAA
CTGATTCCGTGA
ATGTCCAGGAACGAGAAACTGCTGGCCAAGCTACTCAACGAAAGCGCCAGCTTTACCTGGCAGGAGCTTGTGACACTGCT
GCGTTGGCTGGGCTACAGGCAGTTGGAGGGCAGCGGGAGCCGGGTCAAGTTCGACAACGGCGACCCGCTGGCGTTGATCA
ACCTTCACAAGCCGCACCCGGGCAACGAGCTGAAAGCCTATGTCCGGCGCCAGATCATCGAGCACCTCAAGGCGGGGGAA
CTGATTCCGTGA
Antitoxin
Download Length: 114 a.a. Molecular weight: 12663.10 Da Isoelectric Point: 4.8446
>AT63839 WP_064581994.1 NZ_CP015878:1158020-1158361 [Pseudomonas citronellolis]
VNNLLQYRGYYGSIEASTEDNCLFGKLLFIRALVNYEGETVAELQAAFREAVDDYLATCQAQGQEPEVPCKGSFNVRVGH
DLHLAASLEANRQHMSLNDLTRQALSEYLQRHG
VNNLLQYRGYYGSIEASTEDNCLFGKLLFIRALVNYEGETVAELQAAFREAVDDYLATCQAQGQEPEVPCKGSFNVRVGH
DLHLAASLEANRQHMSLNDLTRQALSEYLQRHG
Download Length: 342 bp
>AT63839 NZ_CP015878:1158020-1158361 [Pseudomonas citronellolis]
GTGAACAACCTGCTGCAATACCGGGGCTATTACGGCTCCATCGAAGCCAGCACCGAGGACAACTGCCTGTTCGGCAAGCT
GCTCTTCATCCGCGCGCTGGTCAACTACGAAGGCGAGACGGTGGCCGAACTGCAGGCCGCTTTCCGCGAGGCGGTGGACG
ACTACCTGGCCACATGCCAGGCGCAGGGGCAGGAGCCGGAAGTGCCTTGCAAGGGATCGTTCAACGTGCGGGTCGGCCAT
GACTTGCATCTGGCAGCGAGCCTGGAAGCCAACCGGCAGCACATGAGCCTGAACGACCTCACCCGGCAGGCGCTGAGCGA
GTATTTGCAGCGCCACGGCTGA
GTGAACAACCTGCTGCAATACCGGGGCTATTACGGCTCCATCGAAGCCAGCACCGAGGACAACTGCCTGTTCGGCAAGCT
GCTCTTCATCCGCGCGCTGGTCAACTACGAAGGCGAGACGGTGGCCGAACTGCAGGCCGCTTTCCGCGAGGCGGTGGACG
ACTACCTGGCCACATGCCAGGCGCAGGGGCAGGAGCCGGAAGTGCCTTGCAAGGGATCGTTCAACGTGCGGGTCGGCCAT
GACTTGCATCTGGCAGCGAGCCTGGAAGCCAACCGGCAGCACATGAGCCTGAACGACCTCACCCGGCAGGCGCTGAGCGA
GTATTTGCAGCGCCACGGCTGA
Similar Proteins
Only experimentally validated proteins are listed.
Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
---|
Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
---|
Structures
Toxin
Source | ID | Structure |
---|---|---|
AlphaFold DB | A0A1A9K8U9 |
Antitoxin
Source | ID | Structure |
---|---|---|
AlphaFold DB | A0A1A9K798 |