Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hicAB/HicA(toxin)
Location 1157772..1158361 Replicon chromosome
Accession NZ_CP015878
Organism Pseudomonas citronellolis strain SJTE-3

Toxin (Protein)


Gene name hicA Uniprot ID A0A1A9K8U9
Locus tag A9C11_RS05150 Protein ID WP_064581993.1
Coordinates 1157772..1158023 (+) Length 84 a.a.

Antitoxin (Protein)


Gene name hicB Uniprot ID A0A1A9K798
Locus tag A9C11_RS05155 Protein ID WP_064581994.1
Coordinates 1158020..1158361 (+) Length 114 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
A9C11_RS33925 1154165..1155184 - 1020 WP_082936681.1 UDP-glucose 4-epimerase GalE -
A9C11_RS05140 1155628..1156344 + 717 WP_082936682.1 glycosyltransferase family 25 protein -
A9C11_RS05145 1156446..1157525 + 1080 WP_167543638.1 diguanylate cyclase -
A9C11_RS35210 1157522..1157668 - 147 WP_208858253.1 hypothetical protein -
A9C11_RS05150 1157772..1158023 + 252 WP_064581993.1 type II toxin-antitoxin system HicA family toxin Toxin
A9C11_RS05155 1158020..1158361 + 342 WP_064581994.1 type II toxin-antitoxin system HicB family antitoxin Antitoxin
A9C11_RS05160 1158427..1158654 + 228 WP_064581996.1 DUF433 domain-containing protein -
A9C11_RS05165 1158843..1160039 - 1197 WP_064581998.1 type II toxin-antitoxin system HipA family toxin -
A9C11_RS05170 1160039..1160290 - 252 WP_043272292.1 helix-turn-helix domain-containing protein -
A9C11_RS05175 1160587..1161435 - 849 WP_061560729.1 carboxylating nicotinate-nucleotide diphosphorylase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Genomic island - xcpA/pilD / pilC / pilB 1144629..1160290 15661


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HicA mRNA interferase family

(20-76)

Antitoxin

Uncharacterised protein family HicB

(55-105)


Sequences

Toxin        


Download         Length: 84 a.a.        Molecular weight: 9520.03 Da        Isoelectric Point: 10.0940

>T63839 WP_064581993.1 NZ_CP015878:1157772-1158023 [Pseudomonas citronellolis]
MSRNEKLLAKLLNESASFTWQELVTLLRWLGYRQLEGSGSRVKFDNGDPLALINLHKPHPGNELKAYVRRQIIEHLKAGE
LIP

Download         Length: 252 bp

>T63839 NZ_CP015878:1157772-1158023 [Pseudomonas citronellolis]
ATGTCCAGGAACGAGAAACTGCTGGCCAAGCTACTCAACGAAAGCGCCAGCTTTACCTGGCAGGAGCTTGTGACACTGCT
GCGTTGGCTGGGCTACAGGCAGTTGGAGGGCAGCGGGAGCCGGGTCAAGTTCGACAACGGCGACCCGCTGGCGTTGATCA
ACCTTCACAAGCCGCACCCGGGCAACGAGCTGAAAGCCTATGTCCGGCGCCAGATCATCGAGCACCTCAAGGCGGGGGAA
CTGATTCCGTGA

Antitoxin


Download         Length: 114 a.a.        Molecular weight: 12663.10 Da        Isoelectric Point: 4.8446

>AT63839 WP_064581994.1 NZ_CP015878:1158020-1158361 [Pseudomonas citronellolis]
VNNLLQYRGYYGSIEASTEDNCLFGKLLFIRALVNYEGETVAELQAAFREAVDDYLATCQAQGQEPEVPCKGSFNVRVGH
DLHLAASLEANRQHMSLNDLTRQALSEYLQRHG

Download         Length: 342 bp

>AT63839 NZ_CP015878:1158020-1158361 [Pseudomonas citronellolis]
GTGAACAACCTGCTGCAATACCGGGGCTATTACGGCTCCATCGAAGCCAGCACCGAGGACAACTGCCTGTTCGGCAAGCT
GCTCTTCATCCGCGCGCTGGTCAACTACGAAGGCGAGACGGTGGCCGAACTGCAGGCCGCTTTCCGCGAGGCGGTGGACG
ACTACCTGGCCACATGCCAGGCGCAGGGGCAGGAGCCGGAAGTGCCTTGCAAGGGATCGTTCAACGTGCGGGTCGGCCAT
GACTTGCATCTGGCAGCGAGCCTGGAAGCCAACCGGCAGCACATGAGCCTGAACGACCTCACCCGGCAGGCGCTGAGCGA
GTATTTGCAGCGCCACGGCTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A1A9K8U9

Antitoxin

Source ID Structure
AlphaFold DB A0A1A9K798

References