Detailed information of TA system TA063838

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): relBE/RelE(toxin)
• Location: 1143894..1144363
• Replicon: chromosome
• Accession: NZ_CP015878
• Organism: Pseudomonas citronellolis strain SJTE-3

Toxin (Protein)

• Gene name: relE
• Uniprot ID: -
• Locus tag: A9C11_RS33910
• Protein ID: WP_024128153.1
• Coordinates: 1143894..1144169 (-)
• Length: 92 a.a.

Antitoxin (Protein)

• Gene name: relB
• Uniprot ID: W5IQM6
• Locus tag: A9C11_RS05100
• Protein ID: WP_009617620.1
• Coordinates: 1144169..1144363 (-)
• Length: 65 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
A9C11_RS05060	1139611..1140909	-	1299	WP_064581967.1	NAD(P)/FAD-dependent oxidoreductase	-
A9C11_RS05065	1140956..1141129	-	174	WP_009617611.1	DUF3094 domain-containing protein	-
A9C11_RS05070	1141199..1141828	-	630	WP_009617612.1	DUF1780 domain-containing protein	-
A9C11_RS05075	1141961..1142377	+	417	WP_064581970.1	GNAT family N-acetyltransferase	-
A9C11_RS05080	1142381..1142851	+	471	WP_064581973.1	hypothetical protein	-
A9C11_RS05085	1142848..1143564	+	717	WP_064581977.1	energy-coupling factor ABC transporter permease	-
A9C11_RS05090	1143672..1143887	+	216	WP_043272266.1	hypothetical protein	-
A9C11_RS33910	1143894..1144169	-	276	WP_024128153.1	type II toxin-antitoxin system mRNA interferase toxin, RelE/StbE family	Toxin
A9C11_RS05100	1144169..1144363	-	195	WP_009617620.1	hypothetical protein	Antitoxin
A9C11_RS05105	1144629..1144838	-	210	WP_043272268.1	DNA gyrase inhibitor YacG	-
A9C11_RS05110	1144835..1145443	-	609	WP_064581980.1	dephospho-CoA kinase	-
A9C11_RS05115	1145517..1146389	-	873	WP_064581983.1	A24 family peptidase	-
A9C11_RS05120	1146390..1147607	-	1218	WP_064581985.1	type II secretion system F family protein	-
A9C11_RS05125	1147611..1149314	-	1704	WP_064581987.1	type IV-A pilus assembly ATPase PilB	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, RelE/ParE toxin family (4-90)

Antitoxin

No domain identified.

Sequences

Toxin

Protein

• Length: 92 a.a.
• Molecular weight: 10478.03 Da
• Isoelectric Point: 7.3551

>T63838 WP_024128153.1 NZ_CP015878:c1144169-1143894 [Pseudomonas citronellolis]
VLSIIWRRSASDDLATILAYIANEDPQAARRLKERVESAVLPLAQHPYLYRHGRVPGTREVVIHPNYILVYRIDAECIEV
VSVLHSRQEYP

Nucleotide

• Length: 276 bp

>T63838 NZ_CP015878:c1144169-1143894 [Pseudomonas citronellolis]
GTGCTATCGATCATCTGGCGCAGGAGTGCCAGTGATGACCTCGCGACCATTCTCGCCTATATAGCCAACGAGGATCCCCA
AGCAGCAAGGCGCCTCAAGGAACGCGTGGAGTCTGCCGTGCTGCCGTTGGCCCAGCATCCCTACCTTTACCGTCATGGAC
GAGTACCCGGCACACGAGAAGTCGTGATCCACCCCAACTACATCCTGGTTTACCGGATCGACGCTGAATGCATCGAAGTA
GTCAGCGTCCTGCATTCGCGCCAGGAATATCCCTGA

Antitoxin

Protein

• Length: 65 a.a.
• Molecular weight: 7293.07 Da
• Isoelectric Point: 4.9890

>AT63838 WP_009617620.1 NZ_CP015878:c1144363-1144169 [Pseudomonas citronellolis]
MSARLSPIVSEFETPEQAASHDRWFRQKVQKSLTDNQPGRPHDEVMVDMDAIIAQAEARRQGND

Nucleotide

• Length: 195 bp

>AT63838 NZ_CP015878:c1144363-1144169 [Pseudomonas citronellolis]
ATGAGCGCCCGACTTTCCCCCATAGTCTCCGAGTTCGAAACCCCGGAGCAGGCAGCCAGCCATGATCGCTGGTTCCGCCA
AAAGGTGCAGAAGTCCCTTACAGACAACCAACCAGGGCGTCCCCATGACGAGGTAATGGTCGACATGGACGCCATCATTG
CCCAGGCCGAAGCCCGGCGCCAGGGCAACGACTAG

Structures

Antitoxin

• AlphaFold DB: A0A1A5D6N4