Detailed information of TA system TA063835

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): tad-ata/COG5606-COG4679
• Location: 733029..733647
• Replicon: chromosome
• Accession: NZ_CP015878
• Organism: Pseudomonas citronellolis strain SJTE-3

Toxin (Protein)

• Gene name: tad
• Uniprot ID: A0A1A9KN07
• Locus tag: A9C11_RS03100
• Protein ID: WP_058073322.1
• Coordinates: 733029..733334 (+)
• Length: 102 a.a.

Antitoxin (Protein)

• Gene name: ata
• Uniprot ID: -
• Locus tag: A9C11_RS03105
• Protein ID: WP_043269347.1
• Coordinates: 733327..733647 (+)
• Length: 107 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
A9C11_RS03075	728038..728763	+	726	WP_064581801.1	alpha/beta fold hydrolase	-
A9C11_RS03080	728756..729562	+	807	WP_064581802.1	malonyl-ACP O-methyltransferase BioC	-
A9C11_RS03085	729713..730402	+	690	WP_064581803.1	dethiobiotin synthase	-
A9C11_RS03090	730469..730696	+	228	WP_009615495.1	hypothetical protein	-
A9C11_RS03095	731001..732806	+	1806	WP_009615497.1	phenylacyl-CoA dehydrogenase	-
A9C11_RS03100	733029..733334	+	306	WP_058073322.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
A9C11_RS03105	733327..733647	+	321	WP_043269347.1	helix-turn-helix domain-containing protein	Antitoxin
A9C11_RS03110	733817..735613	+	1797	WP_064581804.1	acyl-CoA dehydrogenase C-terminal domain-containing protein	-
A9C11_RS03115	735832..737610	+	1779	WP_058073296.1	acyl-CoA dehydrogenase C-terminal domain-containing protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin HigB-like (1-89)

Antitoxin

• Cro/C1-type helix-turn-helix domain (30-85)

Sequences

Toxin

Protein

• Length: 102 a.a.
• Molecular weight: 11249.67 Da
• Isoelectric Point: 7.0609

>T63835 WP_058073322.1 NZ_CP015878:733029-733334 [Pseudomonas citronellolis]
MPDDVQDVFGFALHQAQEGGKHPQAKPMKGFSGAGVLEVVEDHDGDTYRAVYTVKFARAVYALHCFQKKSTKGIETPQHD
LELIRKRLKDAQAHAKSVEND

Nucleotide

• Length: 306 bp

>T63835 NZ_CP015878:733029-733334 [Pseudomonas citronellolis]
ATGCCTGACGATGTCCAGGATGTGTTCGGCTTTGCCCTGCACCAGGCGCAGGAAGGTGGCAAGCATCCCCAGGCCAAGCC
GATGAAAGGCTTCTCGGGTGCCGGCGTGCTGGAGGTTGTCGAAGACCATGATGGCGACACCTATAGAGCGGTCTATACAG
TGAAATTTGCAAGGGCGGTCTATGCTCTGCACTGCTTCCAGAAGAAATCGACCAAGGGCATAGAGACTCCGCAGCACGAC
CTGGAGCTGATCAGGAAAAGGCTGAAGGATGCGCAAGCCCATGCGAAGAGCGTAGAGAATGATTGA

Antitoxin

Protein

• Length: 107 a.a.
• Molecular weight: 11579.49 Da
• Isoelectric Point: 10.4649

>AT63835 WP_043269347.1 NZ_CP015878:733327-733647 [Pseudomonas citronellolis]
MIEFEEGSGNVYADLGRADAGEMQVKARLASKIGSIIKARHLTQTQAAEILGLPQPKVSDMLRGKFRGISEAKMIDCLAR
LGRDVQIVVKAAPRSRREGRVEVVFA

Nucleotide

• Length: 321 bp

>AT63835 NZ_CP015878:733327-733647 [Pseudomonas citronellolis]
ATGATTGAGTTCGAAGAAGGCAGCGGCAACGTCTATGCCGACCTCGGCAGGGCCGATGCAGGCGAGATGCAGGTCAAGGC
CAGGCTGGCATCCAAGATCGGTAGCATCATCAAGGCCCGCCACTTGACCCAGACCCAGGCGGCGGAAATCCTCGGGCTCC
CTCAACCCAAGGTTTCCGACATGTTGCGTGGGAAATTCAGAGGCATCAGCGAGGCCAAGATGATCGACTGCCTGGCCCGG
CTCGGACGTGACGTGCAGATCGTGGTCAAGGCCGCACCCCGTTCACGCCGTGAGGGCCGGGTGGAAGTAGTCTTCGCCTG
A

Structures

Toxin

• AlphaFold DB: A0A1A9KN07