Detailed information of TA system TA063828

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): parDE/RHH(antitoxin)
• Location: 874152..874657
• Replicon: chromosome
• Accession: NZ_CP015877
• Organism: Pseudomonas aeruginosa SJTD-1

Toxin (Protein)

• Gene name: parE
• Uniprot ID: V6A7K8
• Locus tag: A214_RS04155
• Protein ID: WP_003083773.1
• Coordinates: 874376..874657 (+)
• Length: 94 a.a.

Antitoxin (Protein)

• Gene name: parD
• Uniprot ID: A0A1C7BDS9
• Locus tag: A214_RS04150
• Protein ID: WP_003083775.1
• Coordinates: 874152..874379 (+)
• Length: 76 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
A214_RS04125	869170..870663	+	1494	WP_003101230.1	CoA-acylating methylmalonate-semialdehyde dehydrogenase	-
A214_RS04130	870832..872259	+	1428	WP_003083784.1	GABA permease	-
A214_RS04135	872341..872682	-	342	WP_003101229.1	alkylphosphonate utilization protein	-
A214_RS04140	872755..873255	-	501	WP_003101228.1	LEA type 2 family protein	-
A214_RS04145	873356..873976	+	621	WP_003101226.1	hypothetical protein	-
A214_RS04150	874152..874379	+	228	WP_003083775.1	CopG family ribbon-helix-helix protein	Antitoxin
A214_RS04155	874376..874657	+	282	WP_003083773.1	type II toxin-antitoxin system toxin ParE	Toxin
A214_RS04160	874957..875865	+	909	WP_003083769.1	LysR family transcriptional regulator	-
A214_RS04165	875897..876283	-	387	WP_003083767.1	aegerolysin family protein	-
A214_RS04170	876487..877221	-	735	WP_003110658.1	GntR family transcriptional regulator	-
A214_RS04175	877322..878008	-	687	WP_003083762.1	FadR family transcriptional regulator	-
A214_RS04180	878057..879406	-	1350	WP_003142411.1	C4-dicarboxylate transporter DctA	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, RelE/ParE toxin family (3-87)

Antitoxin

• Ribbon-helix-helix protein, CopG (5-42)

Sequences

Toxin

Protein

• Length: 94 a.a.
• Molecular weight: 10462.19 Da
• Isoelectric Point: 10.0435

>T63828 WP_003083773.1 NZ_CP015877:874376-874657 [Pseudomonas aeruginosa SJTD-1]
MSLKWTRKAAADLDAIYDHYVVLIGPEKALKAVQDIVEQVKPLQQVANQGAGRPSEVPGVRTLTLERWPFSAPFRVKGKE
IQILRIDRVEITP

Nucleotide

• Length: 282 bp

>T63828 NZ_CP015877:874376-874657 [Pseudomonas aeruginosa SJTD-1]
ATGAGCCTGAAGTGGACCCGCAAGGCGGCCGCCGACCTGGACGCCATCTACGACCATTACGTCGTGCTGATCGGCCCGGA
AAAAGCTCTGAAAGCCGTTCAGGACATCGTCGAGCAGGTGAAACCGCTGCAGCAGGTAGCCAACCAGGGGGCAGGGCGGC
CCAGCGAGGTGCCAGGCGTACGCACCCTGACCCTGGAGCGCTGGCCGTTCAGCGCCCCGTTTCGGGTTAAAGGCAAGGAA
ATCCAGATTTTGCGCATCGACAGGGTCGAAATTACCCCCTGA

Antitoxin

Protein

• Length: 76 a.a.
• Molecular weight: 8556.58 Da
• Isoelectric Point: 5.5740

>AT63828 WP_003083775.1 NZ_CP015877:874152-874379 [Pseudomonas aeruginosa SJTD-1]
MSTVVSFRADDALVAALDELARATHRDRPYHLRQALAQYLERQQWQVAAIDEGLADANAGRLLEHTEIEKRWGLQ

Nucleotide

• Length: 228 bp

>AT63828 NZ_CP015877:874152-874379 [Pseudomonas aeruginosa SJTD-1]
ATGAGCACCGTAGTCTCGTTCCGCGCCGATGACGCCCTGGTCGCGGCCCTCGACGAACTGGCCCGCGCCACCCACCGCGA
CCGCCCCTACCACCTGCGGCAGGCGCTCGCGCAGTACCTGGAAAGGCAGCAGTGGCAGGTCGCTGCCATCGATGAAGGCT
TGGCCGATGCCAATGCCGGCCGCCTGCTGGAACACACCGAGATCGAGAAGCGCTGGGGGCTGCAATGA

Structures

Toxin

• PDB: 6XRW

Antitoxin

• AlphaFold DB: A0A1C7BDS9