Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) Hha-TomB/-
Location 2149906..2150524 Replicon chromosome
Accession NZ_CP015853
Organism Escherichia coli strain ATCC 43889

Toxin (Protein)


Gene name Hha Uniprot ID H5UYE2
Locus tag A8714_RS11575 Protein ID WP_001291435.1
Coordinates 2150306..2150524 (+) Length 73 a.a.

Antitoxin (Protein)


Gene name TomB Uniprot ID -
Locus tag A8714_RS11570 Protein ID WP_001303081.1
Coordinates 2149906..2150280 (+) Length 125 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
A8714_RS11560 2144995..2146188 + 1194 WP_001295324.1 multidrug efflux RND transporter periplasmic adaptor subunit AcrA -
A8714_RS11565 2146211..2149360 + 3150 WP_001132452.1 multidrug efflux RND transporter permease subunit -
A8714_RS11570 2149906..2150280 + 375 WP_001303081.1 Hha toxicity modulator TomB Antitoxin
A8714_RS11575 2150306..2150524 + 219 WP_001291435.1 hemolysin expression modulator Hha Toxin
A8714_RS11580 2150696..2151247 + 552 WP_000102553.1 maltose O-acetyltransferase -
A8714_RS11585 2151363..2151833 + 471 WP_000136192.1 YlaC family protein -
A8714_RS11590 2151997..2153547 + 1551 WP_001301851.1 cyclic-guanylate-specific phosphodiesterase PdeB -
A8714_RS11595 2153589..2153942 - 354 WP_000878140.1 DUF1428 domain-containing protein -
A8714_RS11605 2154321..2154632 + 312 WP_000409911.1 MGMT family protein -
A8714_RS11610 2154665..2155237 - 573 WP_000779831.1 YbaY family lipoprotein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Haemolysin expression modulating, HHA

(13-69)

Antitoxin

Biofilm formation regulator YbaJ

(1-117)


Sequences

Toxin        


Download         Length: 73 a.a.        Molecular weight: 8628.00 Da        Isoelectric Point: 8.9008

>T63802 WP_001291435.1 NZ_CP015853:2150306-2150524 [Escherichia coli]
MSEKPLTKTDYLMRLRRCQTIDTLERVIEKNKYELSDNELAVFYSAADHRLAELTMNKLYDKIPSSVWKFIR

Download         Length: 219 bp

>T63802 NZ_CP015853:2150306-2150524 [Escherichia coli]
ATGTCCGAAAAACCTTTAACGAAAACCGATTATTTAATGCGTTTACGTCGTTGCCAGACAATTGACACGCTGGAGCGTGT
TATCGAGAAAAATAAATACGAATTATCAGATAATGAACTGGCGGTATTTTACTCAGCCGCAGATCACCGCCTCGCCGAAT
TGACCATGAATAAACTGTACGACAAGATCCCTTCCTCAGTATGGAAATTTATTCGCTAA

Antitoxin


Download         Length: 125 a.a.        Molecular weight: 14539.36 Da        Isoelectric Point: 4.7395

>AT63802 WP_001303081.1 NZ_CP015853:2149906-2150280 [Escherichia coli]
MDEYSPKRHDIAQLKFLCETLYHDCLANLEESNHGWVNDPTSAINLQLNELIEHIATFALNYKIKYNEDNKLIEQIDEYL
DDTFILFSSYGINMQDLQKWRKSGNRLFRCFVNATKENPASLSC

Download         Length: 375 bp

>AT63802 NZ_CP015853:2149906-2150280 [Escherichia coli]
ATGGATGAATACTCACCCAAAAGACATGATATCGCACAGCTTAAGTTTCTCTGTGAAACTCTGTATCATGACTGCCTTGC
AAACCTTGAAGAAAGCAATCATGGCTGGGTTAACGACCCAACCTCGGCGATCAACCTCCAGTTGAATGAACTGATTGAGC
ATATTGCGACCTTCGCACTTAATTACAAAATTAAGTATAATGAAGACAATAAGCTCATTGAGCAGATCGACGAATATCTG
GATGACACCTTTATATTGTTCAGTAGTTATGGTATTAATATGCAGGATCTTCAGAAATGGCGGAAGTCAGGTAATCGACT
ATTCCGTTGTTTTGTCAATGCGACGAAAGAGAATCCTGCGAGTTTATCTTGTTAG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 2MW2
PDB 1JW2

Antitoxin

Source ID Structure

References