Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) paaR-paaA-parE/-
Location 1528933..1529411 Replicon chromosome
Accession NZ_CP015853
Organism Escherichia coli strain ATCC 43889

Toxin (Protein)


Gene name parE_1 Uniprot ID A0A891SFN9
Locus tag A8714_RS08670 Protein ID WP_001303876.1
Coordinates 1529124..1529411 (+) Length 96 a.a.

Antitoxin (Protein)


Gene name paaA Uniprot ID Q8XD67
Locus tag A8714_RS08665 Protein ID WP_000536233.1
Coordinates 1528933..1529124 (+) Length 64 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
A8714_RS08630 1524337..1525107 - 771 WP_000450992.1 DUF1627 domain-containing protein -
A8714_RS08635 1525129..1525875 - 747 WP_000788745.1 ATP-binding protein -
A8714_RS08640 1525882..1526973 - 1092 WP_001205823.1 hypothetical protein -
A8714_RS08645 1527052..1527507 + 456 WP_000273724.1 hypothetical protein -
A8714_RS08650 1527714..1528139 - 426 WP_000693855.1 Rha family transcriptional regulator -
A8714_RS08655 1528123..1528395 - 273 WP_000887453.1 helix-turn-helix domain-containing protein -
A8714_RS08660 1528504..1528905 + 402 WP_000986592.1 helix-turn-helix domain-containing protein -
A8714_RS08665 1528933..1529124 + 192 WP_000536233.1 hypothetical protein Antitoxin
A8714_RS08670 1529124..1529411 + 288 WP_001303876.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
A8714_RS08680 1529689..1529844 + 156 WP_000379575.1 DUF1391 family protein -
A8714_RS08685 1529986..1530375 + 390 WP_000394511.1 hypothetical protein -
A8714_RS08690 1530562..1530747 - 186 WP_001133046.1 hypothetical protein -
A8714_RS08700 1531321..1531509 + 189 WP_000413705.1 cell division inhibition protein DicB -
A8714_RS08705 1531506..1531697 + 192 WP_001098307.1 DUF1482 family protein -
A8714_RS08710 1531791..1534262 + 2472 WP_000034474.1 exonuclease -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(4-91)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 96 a.a.        Molecular weight: 10978.84 Da        Isoelectric Point: 10.1360

>T63800 WP_001303876.1 NZ_CP015853:1529124-1529411 [Escherichia coli]
MLPILWLPSARDDLRQIITYIAKENPPAARRLKIRIETSVLPLSEHPYLYPPSERVSGLREIVTHPNYIILYRVAASSIE
IVSVTHSRRQFPFSI

Download         Length: 288 bp

>T63800 NZ_CP015853:1529124-1529411 [Escherichia coli]
ATGTTACCCATTTTATGGCTACCGTCTGCTCGCGATGATTTGCGCCAGATCATAACTTACATCGCCAAGGAGAACCCACC
GGCAGCACGTAGACTAAAAATACGCATTGAAACATCGGTATTACCTCTATCTGAGCATCCGTACTTATATCCACCAAGCG
AACGGGTTTCTGGATTGAGAGAGATCGTGACCCACCCTAACTACATAATCCTGTACAGAGTAGCTGCTTCAAGCATTGAG
ATTGTAAGCGTGACACATTCTCGGCGACAATTTCCCTTCTCTATCTGA

Antitoxin


Download         Length: 64 a.a.        Molecular weight: 7025.80 Da        Isoelectric Point: 4.0270

>AT63800 WP_000536233.1 NZ_CP015853:1528933-1529124 [Escherichia coli]
MGTALSPIVSEFETTEQENSYNEWLRTKVTSSLADTRPAIPHDEVMAEMENLIAQIAVTNKSE

Download         Length: 192 bp

>AT63800 NZ_CP015853:1528933-1529124 [Escherichia coli]
ATGGGTACAGCCCTTTCTCCGATAGTTTCAGAATTCGAAACTACCGAACAAGAAAACAGTTACAACGAATGGTTGCGCAC
TAAAGTAACGTCAAGCCTTGCAGACACTCGCCCCGCAATTCCACATGACGAGGTAATGGCTGAAATGGAAAATCTTATTG
CTCAAATTGCTGTAACTAACAAGAGCGAGTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References